Advanced Research in Oral Oncology

A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 2002

Special Issue Editors


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Guest Editor
Department of Dental Hygiene, China Medical University Taichung, Taichung, Taiwan
Interests: oral biology; oral oncology; microbiology; microRNAs; natural compounds application
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Healthcare Administration, Asia University, Taichung, Taiwan
Interests: biomolecules in salivary exosomes; oral oncology; microbial immunology; preventive dentistry; oral health and masticatory function in older adults

Special Issue Information

Dear Colleagues,

Today, specific medical treatments are applied to improve the lives of patients living with head and neck cancer, including oral squamous carcinoma, all over the world. However, the mortality rate remains high among these patients, especially those in stage 4. To date, the analysis of molecular biology signaling has fostered a better understanding of the research findings that can help us to mediate oral squamous carcinoma with respect to apoptosis, autophagosis, pyroptosis, or ferroptosis. Meanwhile, these findings can inform new concepts for the design and application of anti-cancer drugs. However, many problems inhibiting our efforts to combat the disease still remain unresolved. In this Special Issue, we intend to publish manuscripts focusing on, but not limited to, topics related to advanced anti-cancer drug development, precision medicine, the application of herbs and natural compounds, drug delivery, microbiota in oral cancer patients, the mechanisms of carcinogenesis in oral oncology, radio-chemo-resistant mechanisms, and photodynamic and sonodynamic therapies. Therefore, we are pleased to invite researchers to submit work on these topics in the field of oral oncology, with the aim of updating the therapeutics. We look forward to receiving your contributions.

Prof. Dr. Tzong-Ming Shieh
Dr. Yin-Hwa Shih
Guest Editors

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Keywords

  • anti-cancer drugs
  • autophagosis
  • carcinogenesis
  • exosome
  • ferroptosis
  • microbiota
  • photodynamic and sonodynamic therapies
  • precision medicine
  • pyroptosis
  • radio-chemo-resistant
  • target therapy

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Published Papers (1 paper)

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Research

17 pages, 2628 KiB  
Article
Orai3 Calcium Channel Contributes to Oral/Oropharyngeal Cancer Stemness through the Elevation of ID1 Expression
by Anthony Nguyen, Youngjae Sung, Sung Hee Lee, Charlotte Ellen Martin, Sonal Srikanth, Wei Chen, Mo K. Kang, Reuben H. Kim, No-Hee Park, Yousang Gwack, Yong Kim and Ki-Hyuk Shin
Cells 2023, 12(18), 2225; https://doi.org/10.3390/cells12182225 - 7 Sep 2023
Cited by 2 | Viewed by 1528
Abstract
Emerging evidence indicates that intracellular calcium (Ca2+) levels and their regulatory proteins play essential roles in normal stem cell proliferation and differentiation. Cancer stem-like cells (CSCs) are subpopulations of cancer cells that retain characteristics similar to stem cells and play an [...] Read more.
Emerging evidence indicates that intracellular calcium (Ca2+) levels and their regulatory proteins play essential roles in normal stem cell proliferation and differentiation. Cancer stem-like cells (CSCs) are subpopulations of cancer cells that retain characteristics similar to stem cells and play an essential role in cancer progression. Recent studies have reported that the Orai3 calcium channel plays an oncogenic role in human cancer. However, its role in CSCs remains underexplored. In this study, we explored the effects of Orai3 in the progression and stemness of oral/oropharyngeal squamous cell carcinoma (OSCC). During the course of OSCC progression, the expression of Orai3 exhibited a stepwise augmentation. Notably, Orai3 was highly enriched in CSC populations of OSCC. Ectopic Orai3 expression in non-tumorigenic immortalized oral epithelial cells increased the intracellular Ca2+ levels, acquiring malignant growth and CSC properties. Conversely, silencing of the endogenous Orai3 in OSCC cells suppressed the CSC phenotype, indicating a pivotal role of Orai3 in CSC regulation. Moreover, Orai3 markedly increased the expression of inhibitor of DNA binding 1 (ID1), a stemness transcription factor. Orai3 and ID1 exhibited elevated expression within CSCs compared to their non-CSC counterparts, implying the functional importance of the Orai3/ID1 axis in CSC regulation. Furthermore, suppression of ID1 abrogated the CSC phenotype in the cell with ectopic Orai3 overexpression and OSCC. Our study reveals that Orai3 is a novel functional CSC regulator in OSCC and further suggests that Orai3 plays an oncogenic role in OSCC by promoting cancer stemness via ID1 upregulation. Full article
(This article belongs to the Special Issue Advanced Research in Oral Oncology)
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