From Research to Legalization: How Cannabis Exploits the Endocannabinoid System

A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: 31 December 2024 | Viewed by 419

Special Issue Editors


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Guest Editor
Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria
Interests: fetal development; neuropeptide signaling; psychoactive drugs; maternal drug exposure

E-Mail Website
Guest Editor
Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria
Interests: hypothalamus development; cellular diversity; endocannabinoid signaling; drug addiction

Special Issue Information

Dear Colleague,

This Special Issue titled “From research to legalization: how cannabis exploits the endocannabinoid system” aims to bring together novel developments on the involvement of (endo)-cannabinoid signaling in fundamental brain functions in the context of the ongoing European debate on cannabis legalization. Given the increasing availability of cannabis for medicinal and recreational purposes, the selective cultivation of high-THC strains, as well as novel solutions to more efficiently consume cannabis, it is of crucial importance to put anecdotal evidence on how (endo)-cannabinoid signaling controls the nervous system straight through elegant fundamental research. Therefore, we embark on this special issue to gather the most recent original experimental research, comprehensive reviews, as well as opinion pieces from developmental biology to aging, to cannabinoid pharmacology, to health and disease, as well as translational (“human specific”) segments of science. We thus approach you, leaders in this research arena, for your contribution to help illustrate mechanisms, address societal discussion points, and provide perspectives for law and decision-makers by being involved in this special issue. We are looking forward to your feedback and contributions

Dr. Erik Keimpema
Prof. Dr. Tibor Harkany
Guest Editors

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Keywords

  • endocannabinoids
  • cannabis
  • legalization
  • THC
  • disease
  • development

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Published Papers (1 paper)

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Research

19 pages, 5498 KiB  
Article
Gestational CBD Shapes Insular Cortex in Adulthood
by Daniela Iezzi, Alba Cáceres-Rodríguez, Jessica Pereira-Silva, Pascale Chavis and Olivier Jacques José Manzoni
Cells 2024, 13(17), 1486; https://doi.org/10.3390/cells13171486 - 4 Sep 2024
Viewed by 220
Abstract
Many expectant mothers use CBD to alleviate symptoms like nausea, insomnia, anxiety, and pain, despite limited research on its long-term effects. However, CBD passes through the placenta, affecting fetal development and impacting offspring behavior. We investigated how prenatal CBD exposure affects the insular [...] Read more.
Many expectant mothers use CBD to alleviate symptoms like nausea, insomnia, anxiety, and pain, despite limited research on its long-term effects. However, CBD passes through the placenta, affecting fetal development and impacting offspring behavior. We investigated how prenatal CBD exposure affects the insular cortex (IC), a brain region involved in emotional processing and linked to psychiatric disorders. The IC is divided into two territories: the anterior IC (aIC), processing socioemotional signals, and the posterior IC (pIC), specializing in interoception and pain perception. Pyramidal neurons in the aIC and pIC exhibit sex-specific electrophysiological properties, including variations in excitability and the excitatory/inhibitory balance. We investigated IC’s cellular properties and synaptic strength in the offspring of both sexes from mice exposed to low-dose CBD during gestation (E5–E18; 3 mg/kg, s.c.). Prenatal CBD exposure induced sex-specific and territory-specific changes in the active and passive membrane properties, as well as intrinsic excitability and the excitatory/inhibitory balance, in the IC of adult offspring. The data indicate that in utero CBD exposure disrupts IC neuronal development, leading to a loss of functional distinction between IC territories. These findings may have significant implications for understanding the effects of CBD on emotional behaviors in offspring. Full article
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