Role of c-Jun N-terminal Kinase (JNK) Signaling in Biological Diseases
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Signaling".
Deadline for manuscript submissions: closed (1 July 2020) | Viewed by 74329
Special Issue Editor
2. Neuroscience Department, IRCCS-Istituto Di Ricerche Farmacologiche, "Mario Negri", Via la Masa 19, 20156 Milano, Italy
Interests: synaptic dysfunction; stress signaling pathway; JNK; neuroprotection; neuronal death; acute and chronic brain diseases
Special Issue Information
Dear Colleagues,
The c-Jun N-terminal kinase (JNK) is a MAP kinase, part of a family of serine/threonine protein kinases playing important roles in cellular responses to external stress signals. Since their identification, about 20 years ago, much has been learned of the activation and regulation of the JNK pathway. Three distinct genes, jnk1, jnk2, and jnk3, have been identified, encoding for three JNK isoforms (JNK1, JNK2, and JNK3). JNK1 and JNK2 have broad tissue distribution, while JNK3 is predominantly found in the central nervous system. JNK regulates many biological activities, including inflammatory responses, morphogenesis, cytoskeletal changes, cell proliferation, differentiation, survival and death, as well as gene expression. Importantly, deregulated JNK signaling pathway activation is becoming the focus of screening strategies for new therapeutic approaches to treat human diseases such as diabetes, neurodegenerative conditions, cardiovascular abnormalities, cancer, inflammation, liver disease, and renal fibrosis. JNK acts on a plethora of substrates and regulates a complicated network with diverse biological functions that results in physiological and pathological effects. In recent years, the approaches targeting JNKs as a potential therapeutic target/biomarker are many, and it is clear that it will be important to consider both tissue- and isoform-specific differences.
This Special Issue aims to present the state-of-the-art as well as new ideas and novel findings around the JNK role in different fields:
- JNK in brain diseases;
- JNK in CNS development;
- JNK in genome expression/gene transcription;
- JNK in cancer;
- JNK in diabetes;
- JNK in immunity;
- JNK as a therapeutic target.
We invite the community to submit original articles or reviews in the abovementioned fields. We look forward to your contributions.
Prof. Tiziana Borsello
Guest Editor
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Keywords
- c-Jun N-terminal kinase (JNK)
- brain diseases
- gene transcription
- tumorigenesis
- insulin resistant
- immunity
- inflammation
- survival
- growth
- death
- therapeutic targets
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