Advances in the Research of a Key Molecule in Periostin
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (15 November 2024) | Viewed by 2576
Special Issue Editors
Interests: periostin regulates inflammatory disease; hypertension; gene therapy; periostin & cancer
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Periostin is highly expressed in chronic inflammatory diseases, including asthma, eosinophilic chronic sinusitis/chronic rhinosinusitis with nasal polyp, steroid-resistant atopic dermatitis, chemotherapy-resistant cancer, acute myocardial infarction, congestive heart failure, atherosclerosis, stroke, acute kidney injury, and others. Moreover, periostin plays important roles in the pathogenesis of these diseases. Recently, it has been reported that periostin is involved in type 2 immunity, and is a biomarker of type 2 immunity. Periostin is also a therapeutic target for these diseases, which is why periostin research is very important for intractable diseases.
On the other hand, the protein periostin has a structure composed of an amino-terminal EMI domain, a tandem repeat of 4 fas 1 domains, and a carboxyl-terminal domain including a heparin-binding site at its C-terminal end. Therefore, periostin is one of the fasciclin 1 family. It is becoming clear that both the N-terminal and C-terminal of periostin have important functions.
Dr. Yoshiaki Taniyama
Dr. Nobutaka Koibuchi
Guest Editors
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Keywords
- splicing variant
- cancer
- inflammatory disease
- bone and dental disease
- retinopathy
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