Advances in Autophagy and Brain Injury
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Autophagy".
Deadline for manuscript submissions: closed (1 February 2022) | Viewed by 488
Special Issue Editors
Interests: cerebral hypoxia/ischemia; neuronal death and regeneration; neuroprotection
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Autophagy is a physiological quality-control process that degrades and turns over damaged or senescent organelles and proteins for cellular renewal. This process of self‐digestion is complex and tightly regulated, according to the homeostatic conditions of the cell. Autophagy also controls vital cellular responses induced by different kinds of stresses, including oxidative stress, endoplasmic reticulum stress, mitochondrial changes and inflammation, and crosstalk with apoptosis and necrosis pathways. Several forms of brain injury, including trauma, and focal and global cerebral ischemia, overactivate the autophagy machinery. Although the role of autophagy in the maintenance of tissue homeostasis is well documented, its role during tissue injury and regeneration is still controversial. Several neuroprotective treatments overactivate autophagy, but in some circumstances, the autophagic machinery precipitates cell death and appears to contribute to the etiology of brain injury.
This Special Issue aims to elucidate the role of autophagy in brain injury, highlighting the complex role of autophagy in neurodegeneration and neuroprotection and its crosstalk with apoptosis, necrosis and inflammation.
Dr. Walter Balduini
Dr. Silvia Carloni
Guest Editors
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Keywords
- autophagy
- brain injury
- neurodegeneration
- neuroprotection
- hypoxia
- ischemia
- trauma
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