Epigenetic and Metabolic Regulation of Cancer
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Metabolism".
Deadline for manuscript submissions: closed (20 November 2022) | Viewed by 25046
Special Issue Editors
Interests: cancer; metastasis; epigenetics; chromatin; tumor metabolism; epithelial-–mesenchymal transition (EMT)
Interests: cancer metabolism; cell stress responsive signaling; cancer stem cells; molecular and cellular biology of cancer
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cancer cells distinguish themselves from normal cells by showing aberrant gene expression and altered cellular metabolism, which impact virtually all the characteristics of cancer cells, including rapid proliferation, blocked differentiation, the acquisition of stemness, enhanced survival, motility, invasiveness, metastatic potential, and therapeutic resistance, as well as immune evasion. Irregular gene expression patterns usually result from abnormalities in the epigenetic machinery such as DNA methylation, histone modifications, nucleosome remodeling, 3D genome reorganization, and noncoding RNA modulation. Epigenetic abnormalities can be caused by genetic alterations in genes encoding epigenetic regulators or signaling events that vastly affect their expression. Besides epigenetic dysregulation, cellular metabolism is commonly rewired in cancer cells as a consequence of responses to the tumor microenvironment, genetic mutations in metabolic genes, and epigenetic events that alter metabolic gene expression. Metabolic reprogramming in noncancer cells, in particular immune cells, is also an important aspect of tumor biology. Intriguingly, epigenetic enzymes use specific metabolites as essential cofactors. Their activities are dependent on the availability of such metabolites and thus influenced by cellular metabolism. Both altered cellular metabolism and abnormalities in the epigenetic machinery contribute to cancer pathogenesis. Epigenetic and metabolic regulation, and the crosstalk between metabolic reprograming and epigenetic remodeling offer promising therapeutic opportunities. The reversible nature of epigenetic events has led to the development of epigenetic therapy, whereas metabolic drugs are used in anticancer therapy. Epigenetic therapy, metabolic targeting therapy, and therapies combining them may not only target cancer cells directly, but sometimes also trigger immune responses to achieve improved therapeutic efficacy.
The aim of this Special Issue is to publish original data and reviews elucidating the epigenetic and metabolic regulation of cancer. We hope that your contributions will advance the field and lead to the development of new therapeutic regimens.
Dr. Jianrong Lu
Dr. Ming Tan
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cancer
- epigenetic
- transcription
- chromatin
- tumor metabolism
- immunometabolism
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.