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Chemosensors
Special Issues
Fluorescent Probe and Biosensing
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Fluorescent Probe and Biosensing

A special issue of Chemosensors (ISSN 2227-9040). This special issue belongs to the section "Analytical Methods, Instrumentation and Miniaturization".

Deadline for manuscript submissions: 30 May 2024 | Viewed by 8921

Special Issue Editors

Prof. Dr. Peng Yin

E-Mail Website
Guest Editor
College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, China
Interests: fluorescent probe; biosensing
Dr. Sheng Yang

E-Mail Website
Guest Editor
College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, China
Interests: analytical chemistry; optical sensing; bioimaging

Special Issue Information

Dear Colleagues,

Fluorescent probes have received great interest for their special virtues in recent years. This Special Issue is mainly aimed at small-molecule fluorescent probes, which are applied to the biosensing of reactive species and metals, such as reactive sulfur species, reactive nitrogen species, and reactive oxygen species. Both review articles and original research papers are encouraged in, though not limited to, the following areas:

  • fluorescent probes/sensing
  • fluorescent probes for bioimaging
  • fluorescent probes for biolabeling
  • small molecule-based probes in biosensing
  • fluorescent materials for sensing
  • polymer-based probes in biosensing
  • supramolecular probes in biosensing
  • nanomaterials-based probes in biosensing
  • fluorescent sensing principles and mechanisms

Prof. Dr. Peng Yin
Dr. Sheng Yang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Chemosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • fluorescent probes
  • fluorescence imaging
  • fluorescence microscopy
  • fluorescence sensing
  • nanomaterials based fluorescent probes
  • biosensing

Published Papers (4 papers)

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Research

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13 pages, 3263 KiB  
Article
Near-Infrared Molecular Photosensitizer Decorated with Quaternary Ammonium for High-Efficiency Photothermal Treatment of Bacterial Infections
by Yuxuan He, Na Li, Sha Yang, Xiaofeng Tan, Li Tang and Qinglai Yang
Chemosensors 2023, 11(3), 164; https://doi.org/10.3390/chemosensors11030164 - 01 Mar 2023
Cited by 5 | Viewed by 1562
Abstract
In recent years, pathogenic infections have been a growing health threat due to the proliferation of drug-resistant bacteria, so photothermal therapy (PTT) has gained considerable interest in biological and medical fields, owing to its noninvasive and highly effective properties. However, it is hard [...] Read more.
In recent years, pathogenic infections have been a growing health threat due to the proliferation of drug-resistant bacteria, so photothermal therapy (PTT) has gained considerable interest in biological and medical fields, owing to its noninvasive and highly effective properties. However, it is hard to achieve selective bacteria targeting while generating a large amount of heat at infected sites. Cationic electrostatic interaction is considered to be a common antimicrobial strategy. Herein, an organic molecule named RT-MN was synthesized with four positively charged quaternary ammonium salts that can bind to negatively charged bacteria. Under near-infrared 808 nm laser irradiation, RT-MN could be efficiently converted into a large amount of heat to eradicate bacteria. In addition, its good water solubility and biological safety proved that RT-MN has excellent biological application prospects. Overall, four such positively charged photosensitizer RT-MN, as a non-antibiotic treatment for resistant bacteria, could be promising for the exploration of highly effective antibacterial agents. Full article
(This article belongs to the Special Issue Fluorescent Probe and Biosensing)
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13 pages, 4109 KiB  
Article
Ratiometric Fluorescence Probe of Vesicle-like Carbon Dots and Gold Clusters for Quantitation of Cholesterol
by Shun-Ruei Hu, Chang-Ruei Yang, Yu-Fen Huang, Chih-Ching Huang, Yen-Ling Chen and Huan-Tsung Chang
Chemosensors 2022, 10(5), 160; https://doi.org/10.3390/chemosensors10050160 - 27 Apr 2022
Cited by 5 | Viewed by 2082
Abstract
We report a facile method for the preparation of vesicle-like carbon dots (VCDs) via dry-heating of surfactant solutions. Like most reported CDs, the VCDs possess interesting fluorescence properties. Entrapment of enzymes and gold nanoclusters (AuNCs) inside the VCDs allows for the development of [...] Read more.
We report a facile method for the preparation of vesicle-like carbon dots (VCDs) via dry-heating of surfactant solutions. Like most reported CDs, the VCDs possess interesting fluorescence properties. Entrapment of enzymes and gold nanoclusters (AuNCs) inside the VCDs allows for the development of fluorescent probes for the quantitation of various substrates, with the advantages of high sensitivity and selectivity. The AuNCs act as a probe, and the VCDs as an internal standard confine the AuNCs, enzyme, and analyte to provide high local concentrations to enhance the assay sensitivity. In this study, we employed cholesterol oxidase (ChOX) as a model enzyme for the quantitation of cholesterol. The as-formed hydrogen peroxide through the enzyme reaction inside the VCDs causes fluorescence quenching of AuNCs (excitation/emission wavelengths of 320/670 nm), but not that of the VCDs (excitation/emission wavelengths of 320/400 nm). To improve the sensitivity and linearity, the fluorescence ratios of AuNCs/VCDs are plotted against analyte concentration. The present ratiometric fluorescent method allows for the detection of hydrogen peroxide over the concentration range of 1–100 μM, with a detection limit of 0.673 μM, and cholesterol concentrations ranging from 5 to 100 μM, with a detection limit of 2.8 μM. The practicality of this fluorescent method has been further validated by evaluating cholesterol levels in human serum samples with sufficient accuracy and recovery, revealing its great prospective in diagnosis and biomedical applications. Full article
(This article belongs to the Special Issue Fluorescent Probe and Biosensing)
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Review

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26 pages, 16498 KiB  
Review
Recent Advances in Small Molecular Fluorescence Probes for Fatty Liver Diseases
by Bo Liu, Honghui Yin, Yaxiong Li, Guojiang Mao, Sheng Yang and Kai Zhang
Chemosensors 2023, 11(4), 241; https://doi.org/10.3390/chemosensors11040241 - 12 Apr 2023
Cited by 1 | Viewed by 1948
Abstract
Fatty liver diseases are a spectrum of liver disorders consisting of the benign fatty liver, which could eventually lead to cirrhosis or even hepatocellular cancer (HCC) without timely treatment. Therefore, early diagnosis is crucial for fatty liver diseases. Liver biopsy is regarded as [...] Read more.
Fatty liver diseases are a spectrum of liver disorders consisting of the benign fatty liver, which could eventually lead to cirrhosis or even hepatocellular cancer (HCC) without timely treatment. Therefore, early diagnosis is crucial for fatty liver diseases. Liver biopsy is regarded as the gold standard in the diagnosis of fatty liver diseases. However, it is not recommended for routine use due to its invasiveness and complicated operation. Thus, it is urgent to diagnose fatty liver diseases with non-invasive and precise methods. In this regard, fluorescence imaging technology has attracted intensive attention and become a robust non-invasive method for fatty liver visualization, and a series of fluorescent probes are being intensively designed to track the biomarkers in fatty liver. In this brief review, the small molecular fluorescent probes employed in fatty liver are summarized, mainly focusing on the last four years. Moreover, current opportunities and challenges in the development of fluorescent probes for fatty liver will be highlighted. Full article
(This article belongs to the Special Issue Fluorescent Probe and Biosensing)
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38 pages, 19287 KiB  
Review
Recent Advance in Nucleus-Targeted Fluorescent Probes for Bioimaging, Detection and Therapy
by Cong Hu, Shuai Xu, Zhiling Song, Haixia Li and Hongwen Liu
Chemosensors 2023, 11(2), 125; https://doi.org/10.3390/chemosensors11020125 - 07 Feb 2023
Cited by 7 | Viewed by 2625
Abstract
The nucleus is not only the control hub of cell life activities, but also the center of storing and controlling genetic information. The morphology of the nucleus can be used to judge the cell vitality and health. The various biological molecules contained in [...] Read more.
The nucleus is not only the control hub of cell life activities, but also the center of storing and controlling genetic information. The morphology of the nucleus can be used to judge the cell vitality and health. The various biological molecules contained in the nucleus are closely related to the normal life activities, occurrence and development of diseases. In recent years, fluorescence imaging has gained increasing attention due to its advantages of being intuitive, in situ and visual. The development of fluorescent probes for high-resolution imaging of the nucleus and detection of biomolecules in the nucleus is of great value for understanding the normal physiological processes of cells or organisms, as well as for disease diagnosis and treatment. In this review, we mainly introduce the current general strategies for designing nucleus-targeted fluorescent probes, as well as their applications in nucleus-targeted imaging, intranuclear biomolecular detection and therapy. Moreover, we also discuss the current challenges and opportunities of nucleus-targeted fluorescent probes in terms of selectivity, design strategies and so on. Full article
(This article belongs to the Special Issue Fluorescent Probe and Biosensing)
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