Microbial Engineering: Gene Expression Regulation and Its Application

Dear Colleagues,

Substantial progress has been made in understanding mechanisms of gene expression regulation at the molecular level. This knowledge has been extended into different areas of cell biology and beyond, revealing its critical importance and complexity. Gene expression regulation is now considered a multidimensional process involving signaling pathways and epigenetics along with transcriptional, post-transcriptional and translational regulation. Comprising a large number of molecular and genetic components with an even larger number of their interactions, the process with such enormous complexity requires a systematic study approach.

This Special Issue focuses on research aimed at the identification and characterization of gene expression regulation features and mechanisms in biotechnologically relevant microorganisms. Synthetic biology approaches and metabolic engineering with application gene expression control tools and systems with the aim to develop highly performing biocatalysts are of particular interest.

The Special Issue welcomes submissions covering, but not limited to, the following themes:

• Transcriptional and translational regulation;
• Structure and function of regulatory elements such as gene promoters, operators, ribosome binding sites and other gene expression regulatory elements;
• Mapping of regulatory elements;
• Identification and development of gene expression control systems;
• Regulatory network reconstruction;
• Computational approaches for studying gene expression regulation and regulatory elements;
• Gene expression in microbial engineering and synthetic biology;
• Use of gene expression control elements for developing synthetic biology tools;
• Application of gene expression control elements for developing biosynthetic pathways.

Dr. Naglis Malys
Guest Editor

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