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Tumor Immunology: From Molecular Mechanisms to Treatment

A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Molecular Medicine".

Deadline for manuscript submissions: closed (31 August 2024) | Viewed by 875

Special Issue Editor


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Guest Editor
Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY 10065, USA
Interests: immunology; cell metabolism; inflammation & infection; cancer; redox biology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Modern medicine has made steady progress in understanding the fundamental interactions between cancer and the host immune system. Recent research articles are focused on underpinning of the complex relationship between the cancer microenvironment and immune cells and showcase the latest advances in the field and provide up-to-date information. Therefore, we are intrigued about the molecular mechanisms, physiological connections, and potential immunomodulatory pathways between immune cells and cancer cells involving their crosstalk at cellular metabolism level. Meanwhile, we are learning how different anti-cancer treatments, including monoclonal antibodies, immunotoxins, bispecific antibodies, T-cell therapy, etc., affect the immune system, and how all of this affects tumor responses.

We welcome submissions of original research papers and reviews, including but not limited to the following topics:

  • Mechanism of cancer immunotherapy and its effect on the immune system
  • TME control of tumor cell death
  • Immunometabolism in the tumor microenvironment
  • Changes in the immune system during cancer treatment in clinical trials
  • Cell death induction mechanism of tumor immunogenicity

Dr. Deepika Awasthi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cellular metabolism
  • metabolic reprogramming
  • immunometabolism
  • tumor microenvironment
  • immunotherapy
  • metabolites
  • immunosuppression
  • immune cells
  • tumor cells

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Published Papers (1 paper)

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Research

17 pages, 3652 KiB  
Article
Reciprocal Interactions of Human Monocytes and Cancer Cells in Co-Cultures In Vitro
by Roman Paduch, Maria Klatka, Paulina Pieniądz, Iwona Wertel, Anna Pawłowska and Janusz Klatka
Curr. Issues Mol. Biol. 2024, 46(7), 6836-6852; https://doi.org/10.3390/cimb46070408 - 2 Jul 2024
Viewed by 670
Abstract
The tumor microenvironment (TME) includes immune and stromal cells and noncellular extracellular matrix (ECM) components. Tumor-associated macrophages (TAMs) are the most important immune cells in TME and are crucial for carcinomas’ progression. The purpose was to analyze direct and indirect interactions in co-culture [...] Read more.
The tumor microenvironment (TME) includes immune and stromal cells and noncellular extracellular matrix (ECM) components. Tumor-associated macrophages (TAMs) are the most important immune cells in TME and are crucial for carcinomas’ progression. The purpose was to analyze direct and indirect interactions in co-culture of tumor cells with monocytes/macrophages and, additionally, to indicate which interactions are more important for cancer development. Cytokines, reactive oxygen species, nitric oxide level, tumor cell cycle and changes in tumor cell morphology after human tumor cells (Hep-2 and RK33 cell lines) with human monocyte/macrophage (THP-1 cell line) interactions were tested. Morphology and cytoskeleton organization of tumor cells did not change after co-culture with macrophages. In co-culture of tumor cells with human monocyte, changes in the percentage of tumor cells in cell cycle phases was observed. No significant changes in reactive oxygen species (ROS) were found in the co-culture as compared to the tumor cell mono-culture. Monocytes produced about three times higher ROS than tumor cells. In co-cultures, a lower nitric oxide (NOx) level was found as compared to the sum of the production by both mono-cultures. Co-culture conditions limited the production of cytokines (IL-4, IL-10 and IL-13) as compared to the sum of their level in mono-cultures. In conclusion, macrophages influence tumor cell growth and functions. Mutual (direct and paracrine) interactions between tumor cells and macrophages changed cytokine production and tumor cell cycle profile. The data obtained may allow us to initially indicate which kind of interactions may have a greater impact on cancer development processes. Full article
(This article belongs to the Special Issue Tumor Immunology: From Molecular Mechanisms to Treatment)
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