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Stem Cell-Derived Cells and Bioengineering: Molecular Bases in Regeneration and Disease Research

A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Molecular Medicine".

Deadline for manuscript submissions: 30 September 2026 | Viewed by 498

Special Issue Editor


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Guest Editor
Department of Biomedical Engineering, Widener University, Chester, PA 19013, USA
Interests: tissue engineering; disease modeling; aging; iPSCs; interorgan communication; tissue/organ decellularization and recellularization
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Stem cell-derived cells are at the forefront of regenerative medicine and disease modeling, offering unprecedented insights into human development, tissue repair, and pathological mechanisms. This Special Issue, "Stem Cell-Derived Cells and Bioengineering: Molecular Bases in Regeneration and Disease Research", will bring together advances in stem cell technologies and bioengineering to explore their synergy in health and disease contexts. Contributions will highlight novel methods for deriving specific cell types from stem cells, molecular pathways guiding cell fate decisions, and innovative bioengineering platforms such as organoids and organ-on-chip models for mimicking physiological and pathological conditions. By integrating stem cell biology into bioengineering, this Special Issue will provide a comprehensive overview of how these tools are reshaping biomedical research, drug discovery, and the development of personalized therapies.

Dr. Aylin Acun
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Current Issues in Molecular Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • stem cells
  • regenerative medicine
  • bioengineering
  • disease modeling
  • organoids
  • tissue engineering
  • decellularization
  • bioprinting

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Published Papers (1 paper)

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Research

19 pages, 4411 KB  
Article
ADSC-Conditioned Medium Mitigates LPS-Induced Acute Lung Injury by Inhibiting Alveolar Macrophage Pyroptosis
by Fan Yang, Jiachen Li, Ziyi Ren, Chuanyu Zhang, Mingwei Xing and Zhihui Jiao
Curr. Issues Mol. Biol. 2026, 48(3), 253; https://doi.org/10.3390/cimb48030253 - 26 Feb 2026
Viewed by 257
Abstract
Acute lung injury (ALI) is characterized by overwhelming pulmonary inflammation and high mortality, yet specific pharmacological interventions remain critically limited. Adipose-derived mesenchymal stem cell-conditioned medium (ADSC-CM) represents a novel cell-free strategy with substantial therapeutic potential. This study investigated the protective effects of ADSC-CM [...] Read more.
Acute lung injury (ALI) is characterized by overwhelming pulmonary inflammation and high mortality, yet specific pharmacological interventions remain critically limited. Adipose-derived mesenchymal stem cell-conditioned medium (ADSC-CM) represents a novel cell-free strategy with substantial therapeutic potential. This study investigated the protective effects of ADSC-CM in a rat model of lipopolysaccharide (LPS)-induced ALI. Systemic administration of ADSC-CM significantly attenuated pulmonary pathological damage, reduced systemic inflammatory cytokine levels, and inhibited pyroptosis within lung tissues. Mechanistically, in vitro studies using the NR8383 alveolar macrophage (AM) cell line revealed that ADSC-CM suppressed the TLR4/MyD88/NF-κB signaling axis and the NLRP3/Caspase-1/GSDMD-mediated pyroptotic cascade. These effects were primarily driven by the downregulation of TLR4 expression, although additional molecular targets likely contribute to this protective profile. Our findings highlight the therapeutic efficacy of ADSC-CM in modulating pyroptosis and inflammatory responses in AMs, providing a robust mechanistic rationale for developing ADSC-CM as a cell-free therapeutic platform for the management of ALI. Full article
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