Structure and Function of Proteins: From Bioinformatics Insights

Dear Colleagues,

In complex biological systems, there are different levels of orchestration of agency and function: organs and cells work in concert to perform complex operations, and they are composed of a variety of proteins that play fundamental roles in internal and external interactions. At the same time, bioinformatics has become essential for elucidating the links between protein structure, dynamics, and function, as well as for understanding target-based drug discovery approaches. It is therefore clear that an integrated approach combining different computational and experimental techniques will provide more comprehensive and mechanistic insights into protein structure and function.

In this Special Issue, we will explore the application of bioinformatics in key areas such as prediction of 3D structures of unstructured proteins, prediction of gene expression, identification of transposable elements, and prediction of interactions between biologically important proteins (e.g., druggable proteins) and ligands.

In addition, reports are encouraged to propose new experimental or computational methods for the interpretation and understanding of biophysical-chemical data, structural studies of proteins and macromolecular assemblies, modification of protein structure and function via molecular biology and genetics techniques, conditions for functional analysis under physiology, and protein interactions with receptors, nucleic acids, or other specific ligands or substrates. Protein and peptide biochemistry studies aimed at synthesizing or characterizing molecules that mimic active aspects of proteins or act as inhibitors of protein function are also welcome.

Dr. Jianwen Fang
Guest Editor

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