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Molecular Mechanisms and Regulation in Allergy and Immune Diseases, Immunodeficiencies, 2nd Edition

A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Molecular Medicine".

Deadline for manuscript submissions: 31 March 2025 | Viewed by 647

Special Issue Editor

Special Issue Information

Dear Colleagues,

Allergies and other immunity disorders are a current and deepening problem of the modern world, closely related to the progress of civilization. Although many mechanisms mediating allergic reactions have already been clearly explained, there are still many unclear mechanisms of these reactions. Also, the relationship between allergens from different sources often remains a surprising mystery. Immunodeficiency and immune disorders are also serious health problems in the modern world. The coexistence of various immune system disorders (such as allergies and immunodeficiencies) often entails diagnostic difficulties. Many times, we face the problem of our diagnostic tools being insufficient. This entails constructing new experimental laboratory methods to study the relationship between different allergens and the mechanisms of allergies and other immunologically mediated diseases. In this Special Issue, we want to focus on the mechanisms of allergic reactions, especially those atypical and accompanying immune disorders. We will try to present significant problems and difficulties related to the diagnosis of allergies, especially in unusual cases. We also want to present the possibilities of using experimental methods and laboratory protocols to study the mechanisms of allergy and cross-reactivity.

Potential topics will include:

  • Mechanisms of allergic reactions;
  • Co-factors of allergic reactions;
  • Unusual allergic reactions;
  • Allergies in immunodeficiency;
  • Cross-reactive allergens;
  • Experimental laboratory methods in allergology;
  • In vitro allergy diagnosis;
  • Biochemical properties of allergens;
  • New potential allergens.

You can read the publications in the first volume here:

https://www.mdpi.com/journal/cimb/special_issues/1NCDUD4Y16

Dr. Kinga Lis
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Current Issues in Molecular Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • allergy and hypersensitivity mechanisms
  • cross-reactivity in allergy
  • component resolved diagnostic (CRD)
  • immunodeficiencies
  • experimental research methods in allergology
  • biochemical properties of allergens

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Published Papers (2 papers)

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Research

17 pages, 1815 KiB  
Article
Decoding the Genetic Basis of Mast Cell Hypersensitivity and Infection Risk in Hypermobile Ehlers-Danlos Syndrome
by Purusha Shirvani, Arash Shirvani and Michael F. Holick
Curr. Issues Mol. Biol. 2024, 46(10), 11613-11629; https://doi.org/10.3390/cimb46100689 - 17 Oct 2024
Viewed by 207
Abstract
Hypermobile Ehlers-Danlos syndrome (hEDS) is a connective tissue disorder marked by joint hypermobility, skin hyperextensibility, and tissue fragility. Recent studies have linked hEDS with mast cell activation syndrome (MCAS), suggesting a genetic interplay affecting immune regulation and infection susceptibility. This study aims to [...] Read more.
Hypermobile Ehlers-Danlos syndrome (hEDS) is a connective tissue disorder marked by joint hypermobility, skin hyperextensibility, and tissue fragility. Recent studies have linked hEDS with mast cell activation syndrome (MCAS), suggesting a genetic interplay affecting immune regulation and infection susceptibility. This study aims to decode the genetic basis of mast cell hypersensitivity and increased infection risk in hEDS by identifying specific genetic variants associated with these conditions. We conducted whole-genome sequencing (WGS) on 18 hEDS participants and 7 first-degree relatives as controls, focusing on identifying genetic variants associated with mast cell dysregulation. Participants underwent clinical assessments to document hEDS symptoms and mast cell hypersensitivity, with particular attention to past infections and antihistamine response. Our analysis identified specific genetic variants in MT-CYB, HTT, MUC3A, HLA-B and HLA-DRB1, which are implicated in hEDS and MCAS. Protein–protein interaction (PPI) network analysis revealed significant interactions among identified variants, highlighting their involvement in pathways related to antigen processing, mucosal protection, and collagen synthesis. Notably, 61.1% of the hEDS cohort reported recurrent infections compared to 28.5% in controls, and 72.2% had documented mast cell hypersensitivity versus 14.2% in controls. These findings provide a plausible explanation for the complex interplay between connective tissue abnormalities and immune dysregulation in hEDS. The identified genetic variants offer insights into potential therapeutic targets for modulating mast cell activity and improving patient outcomes. Future research should validate these findings in larger cohorts and explore the functional implications of these variants to develop effective treatment strategies for hEDS and related mast cell disorders. Full article
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13 pages, 1651 KiB  
Article
Impact of Dupilumab on Skin Surface Lipid-RNA Profile in Severe Asthmatic Patients
by Yoshihiko Sato, Hitoshi Sasano, Sumiko Abe, Yuuki Sandhu, Shoko Ueda, Sonoko Harada, Yuki Tanabe, Kyoko Shima, Tetsuya Kuwano, Yuya Uehara, Takayoshi Inoue, Ko Okumura, Kazuhisa Takahashi and Norihiro Harada
Curr. Issues Mol. Biol. 2024, 46(10), 11425-11437; https://doi.org/10.3390/cimb46100680 - 15 Oct 2024
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Abstract
The analysis of skin surface lipid-RNAs (SSL-RNAs) provides a non-invasive method for understanding the molecular pathology of atopic dermatitis (AD), but its relevance to asthma remains uncertain. Although dupilumab, a biologic drug approved for both asthma and AD, has shown efficacy in improving [...] Read more.
The analysis of skin surface lipid-RNAs (SSL-RNAs) provides a non-invasive method for understanding the molecular pathology of atopic dermatitis (AD), but its relevance to asthma remains uncertain. Although dupilumab, a biologic drug approved for both asthma and AD, has shown efficacy in improving symptoms for both conditions, its impact on SSL-RNAs is unclear. This study aimed to investigate the impact of dupilumab treatment on SSL-RNA profiles in patients with severe asthma. An SSL-RNA analysis was performed before and after administering dupilumab to asthma patients requiring this intervention. Skin samples were collected non-invasively from patients before and after one year of dupilumab treatment. Although 26 patients were enrolled, an SSL-RNA analysis was feasible in only 7 due to collection challenges. After dupilumab treatment, improvements were observed in asthma symptoms, exacerbation rates, and lung function parameters. Serum levels of total IgE and periostin decreased. The SSL-RNA analysis revealed the differential expression of 218 genes, indicating significant down-regulation of immune responses, particularly those associated with type 2 inflammation, suggesting potential improvement in epithelial barrier function. Dupilumab treatment may not only impact type 2 inflammation but also facilitate the normalization of the skin. Further studies are necessary to fully explore the potential of SSL-RNA analysis as a non-invasive biomarker for evaluating treatment response in asthma. Full article
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