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Life
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Allergies and Allergic Diseases—Perspectives in Diagnosis and Management
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Allergies and Allergic Diseases—Perspectives in Diagnosis and Management

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: closed (14 October 2023) | Viewed by 5984

Special Issue Editors

Dr. Natalia Ukleja-Sokołowska

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Guest Editor
Department of Allergology, Clinical Immunology and Internal Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland
Interests: shrimp allergy; alfa-gal; anaphylaxis; wheat dependent exercise induced anaphylaxis; cross-allergy
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Kinga Lis

E-Mail Website
Guest Editor
Department of Allergology, Clinical Immunology and Internal Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, ul. Ujejskiego 75, 85-168 Bydgoszcz, Poland
Interests: food additive; immunology; alergology
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Francesca Larese Filon

E-Mail Website
Guest Editor
Department of Medicine, Surgery and Health Sciences, University of Trieste, 34127 Trieste, Italy
Interests: contact dermatitis; patch test; occupational dermatitis; skin absorption of chemicals; skin protection
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The diagnosis and management of allergic diseases are difficult tasks in many cases. Component-resolved diagnosis was a game-changing development, allowing us to identify the patterns of sensitization. Furthermore, it allowed us to indirectly identify the proteins behind cross-sensitization. Double-blind placebo-controlled food challenges remain the gold-standard approach in the diagnosis of food allergies, whereas skin prick tests allow the diagnosis of pollen and house dust mite sensitization. Basophile-activation tests are interesting tools, which allow in vitro challenges to be performed, eliminating the risk for patients. These methods all have benefits, but they remain insufficient in many cases. In this Special Issue, we welcome research on different diagnostic tools for allergies and current trends in the management of allergic disorders.

Other topics which will be considered for this Special Issue include research on allergens, allergen isoforms, new allergens, and ligand–allergen interactions.

We look forward to receiving your high-quality submissions.

Dr. Natalia Ukleja-Sokołowska
Dr. Kinga Lis
Prof. Dr. Francesca Filon
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • allergy
  • anaphylaxis
  • cross-allergies
  • IgE
  • exercise-induced anaphylaxis
  • component-resolved diagnosis

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Published Papers (2 papers)

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Research

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11 pages, 1474 KiB  
Article
A Food Matrix Triggers a Similar Allergic Immune Response in BALB/c Mice Sensitized with Native, Denatured, and Digested Ovalbumin
by Jesús Gilberto Arámburo-Gálvez, Raúl Tinoco-Narez-Gil, Aldo Alejandro Arvizu-Flores, Oscar Gerardo Figueroa-Salcido, José Antonio Mora-Melgem, Alma Rosa Islas-Rubio, Lilian Karem Flores-Mendoza, Veronica Lopez-Teros, Humberto Astiazaran-Garcia, Feliznando Isidro Cárdenas-Torres and Noé Ontiveros
Life 2023, 13(8), 1733; https://doi.org/10.3390/life13081733 - 12 Aug 2023
Viewed by 1449
Abstract
The search for an animal model to evaluate the allergenic potential of processed food products is still ongoing. Both the sensitization to ovalbumin (OVA) in different structural states and the allergic response triggered after intragastric or food challenges were assessed. BALB/c mice were [...] Read more.
The search for an animal model to evaluate the allergenic potential of processed food products is still ongoing. Both the sensitization to ovalbumin (OVA) in different structural states and the allergic response triggered after intragastric or food challenges were assessed. BALB/c mice were sensitized intraperitoneally to OVA (50 µg) in different structural states (native OVA, N-OVA; denatured OVA, D-OVA; formaldehyde- and lysine-treated OVA, FK-OVA; denatured OVA-FK, OVA-DFK; peptides from pepsin digestion, Pep-OVA). Anti-OVA-specific IgE responses were evaluated using ELISA. Anaphylactic signs and mMCP-1 serum levels were evaluated after intragastric (2.0 mg/OVA) and food (0.41 mg/OVA) challenges. IgE reactivities to N-OVA and D-OVA were similar among groups (p > 0.05). After the challenges, all OVA-sensitized mice developed mild to severe anaphylactic signs (p < 0.05 vs. control). Mice sensitized to N-OVA and D-OVA had the highest mMCP-1 serum levels after challenges (p < 0.05 vs. control). Allergic responses were similar despite the different OVA doses used for the challenges. The N-OVA-sensitized murine model of egg allergy proposed in the present study holds the potential for evaluating the impact of food matrix composition and processing on the threshold of egg-allergic responses. Full article
(This article belongs to the Special Issue Allergies and Allergic Diseases—Perspectives in Diagnosis and Management)
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Review

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16 pages, 1242 KiB  
Review
Biologics for Chronic Rhinosinusitis—A Modern Option for Therapy
by Romica Cergan, Ovidiu Nicolae Berghi, Mihai Dumitru, Daniela Vrinceanu, Felicia Manole and Crenguta Sorina Serboiu
Life 2023, 13(11), 2165; https://doi.org/10.3390/life13112165 - 5 Nov 2023
Cited by 18 | Viewed by 3827
Abstract
Chronic rhinosinusitis (CRS) is an important ENT pathology which affects about 5–12% of the general population. The treatment of CRS can be pharmacological (nasal sprays, douches, systemic antibiotics and steroids), surgical (endoscopic sinus surgery) or immunological according to established algorithms. CRS was divided [...] Read more.
Chronic rhinosinusitis (CRS) is an important ENT pathology which affects about 5–12% of the general population. The treatment of CRS can be pharmacological (nasal sprays, douches, systemic antibiotics and steroids), surgical (endoscopic sinus surgery) or immunological according to established algorithms. CRS was divided for many years into CRS with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP). New ways of classifying CRS by endotypes (presence of neutrophilia, eosinophilia, fibrosis, glandular hypertrophy and epithelial dysmorphisms) appeared after the most recent understandings of the pathophysiology of the disease. Other classifications divide CRS into primary and secondary forms, localized/diffuse types and anatomical presentation. A new type of treatment has been administered in the last years, biologics. For the moment, biologics are indicated just in the cases of the patients who have undergone ESS or have contraindications for surgery and have bilateral polyps and meet a minimum of three of the following criteria: the necessity for systemic therapies with oral or parenteral corticosteroids or contraindications to systemic steroids, significant loss of smell or impaired QoL score, comorbid asthma and type 2 inflammation. This article aims to present the most relevant studies which used the three types of biologics (anti-IgE, anti-IL5 and anti-IL4/IL3) and wishes to increase the awareness of this new type of treatment that can be used in some CRS cases. Full article
(This article belongs to the Special Issue Allergies and Allergic Diseases—Perspectives in Diagnosis and Management)
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