Cerebrovascular Diseases: From Pathogenesis to Treatment
A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: 30 April 2025 | Viewed by 1113
Special Issue Editors
Interests: cerebrovascular diseases; lacunar strokes; acute stroke; vascular cognitive impairment
Special Issues, Collections and Topics in MDPI journals
Interests: stroke; iron dyshomeostasis; excitotoxicity; ferroptosis; new-generation therapies; glutamate excitotoxicity; transferrin; free radicals; therapeutic targets; proteomics
Special Issues, Collections and Topics in MDPI journals
Interests: cerebrovascular diseases; stroke; biomarkers; animal model; omics; ischemic tolerance; remote ischemic tolerance; cognitive impairment; PROMS
Special Issue Information
Dear Colleagues,
Stroke remains a leading cause of death and disability and has a complex pathophysiology. Increasing evidence suggests that the brain is exquisitely sensitive to even short-duration ischemia, and that multiple mechanisms are involved in the tissue damage that results from cerebral ischemia. Ischemic stroke initiates a cascade of events including ATP depletion, ionic dysregulation, increased release of glutamate, excess production of free radicals, and edema and inflammation; all these events eventually contribute to cell death. In contrast, in intracerebral hemorrhage, the oppression and destruction of brain tissue by hematoma is the primary cause of brain injury, but inflammation, coagulation response, and the toxicity of the released hemoglobin play a pivotal role as well. Cell death after stroke has been attributed in the past mainly to necrosis or apoptosis, but recent reports show the involvement of other newly described forms of cell death.
Recently, there has been a relevant interest in disease-modifying therapies in acute stroke, and novel approaches have been attempted to enhance recovery, reducing long-term disabilities.
This Special Issue of Current Issues in Molecular Biology will explore the current knowledge and innovative concepts regarding preclinical and clinical research into stroke mechanisms, prevention, and treatment and provide a critical overview of the underlying factors involved in stroke-related brain injury, especially the role of cell signaling in excitotoxicity, inflammation, apoptosis, and the newly described types of cell death such as ferroptosis and their potential treatment. Gene and protein expression profiles after stroke and neurogenesis, angiogenesis, and neuroplasticity are other important features in stroke and should lead to the better understanding of the pathophysiology of acute stroke.
We warmly welcome submissions, including original articles and reviews, on these hot topics.
Dr. Adria Arboix
Dr. Teresa Gasull
Dr. Francisco Purroy
Guest Editors
Manuscript Submission Information
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Keywords
- stroke
- ischemic
- hemorrhagic
- neuronal death
- molecular mechanisms
- inflammation
- epigenetics
- ischemic tolerance
- ferroptosis
- free radicals
- treatment
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