Adjuvant Chemotherapy for Colorectal Cancer: State of the Art and Future Perspectives
A special issue of Current Oncology (ISSN 1718-7729).
Deadline for manuscript submissions: closed (1 May 2022) | Viewed by 3238
Special Issue Editors
2. Instituto de Salud Carlos III, CIBERONC, Madrid, Spain
Interests: liquid biopsy; colorectal cancer; CDX2 marker; translational research
Interests: liquid biopsy; colorectal cancer; CDX2 marker; lung cancer; translational research
Special Issue Information
Dear Colleagues,
Colorectal cancer (CRC) is a major health issue worldwide. A considerable challenge is the identification of patients at high risk of recurrence after curative intent surgery. Currently, staging is based upon the pathological analysis of the resected specimen, and it is the gold standard for determining prognosis and for adjuvant chemotherapy (ACT) decision making. However, despite an optimal initial treatment, up to 40% of patients will relapse. The identification of new predictive and prognostic markers could help to identify patients at high risk of relapse and establish innovative therapeutic options to optimize adjuvant treatment. Plasma circulating tumor DNA is a potential new biomarker detecting minimal residual disease (MRD) and accurately monitoring patients’ response to ACT. Additionally, the characterization of circulating tumor cells may determine whether any novel approach to MRD can lead to the selection of personalized treatments that improve response over current standard therapies. On the other hand, the value of CDX2 expression, deep-learning radiomics-based prediction of distant metastasis, and generation of organoids as a preclinical model may help to better select patients to ACT and develop new strategies guiding CRC patient treatment.
Dr. Noelia Tarazona
Dr. Francisco Gimeno-Valiente
Dr. Elena Duréndez Sáez
Guest Editors
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Keywords
- localized colon cancer
- pathological staging
- adjuvant chemotherapy
- circulating tumor DNA
- CDX2 expression
- clinical trials
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