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Diagnostics
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Advance in the Diagnostic of Atherosclerosis
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Advance in the Diagnostic of Atherosclerosis

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 1225

Special Issue Editor

Prof. Dr. Meral Kayikcioglu

E-Mail Website
Guest Editor
Ege University Medical School, Izmir, Turkey
Interests: atherosclerosis; heart failure; echocardiography; hereditary thrombophilia; cardiovascular

Special Issue Information

Dear Colleagues, 

Atherosclerosis (AS) is the main cause of coronary heart disease, cerebral infarction, and peripheral vascular disease, and has attracted widespread attention in relation to global health. The main risk factors of atherosclerosis include hypertension, hyperlipidemia, diabetes, obesity, and genetic factors. Early diagnosis and management of atherosclerosis is the focus of attention in cardiovascular diseases, such as the evaluation and treatment of hypercholesterolemia, heart failure, coronary artery stenosis. This Special Issue aims to describe current advances in the early diagnosis, treatment, and prognosis of atherosclerosis. Original research articles and reviews are welcome, and research areas may include (but are not limited to) the following:

  • Atherosclerosis
  • Heart Failure
  • Echocardiography
  • Hereditary Thrombophilia
  • Cardiovascular

We look forward to your contribution.

Prof. Dr. Meral Kayikcioglu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • atherosclerosis
  • heart failure
  • echocardiography
  • hereditary thrombophilia
  • cardiovascular
 

Published Papers (1 paper)

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Research

14 pages, 2028 KiB  
Article
One Step Back from Bedside to the Bench—How Do Different Arterial Stiffness Parameters Behave in Relation to Peripheral Resistance?
by Nóra Obajed Al-Ali, Sára Rebeka Tóth, László Váróczy, László Imre Pinczés, Pál Soltész, Zoltán Szekanecz and György Kerekes
Diagnostics 2023, 13(18), 2897; https://doi.org/10.3390/diagnostics13182897 - 9 Sep 2023
Viewed by 1001
Abstract
The investigation of arterial stiffening is a promising approach to estimating cardiovascular risk. Despite the widespread use of different methods, the dynamic nature of measured and calculated stiffness parameters is marginally investigated. We aimed to determine the stability of large artery elasticity parameters [...] Read more.
The investigation of arterial stiffening is a promising approach to estimating cardiovascular risk. Despite the widespread use of different methods, the dynamic nature of measured and calculated stiffness parameters is marginally investigated. We aimed to determine the stability of large artery elasticity parameters assessed via commonly used, ultrasound-based and oscillometric methods in relation to peripheral resistance modulation. A human experimental environment was composed, and fifteen young males were investigated at rest after extremity heating and external compression. Functional vascular parameters were monitored in each session, and several arterial stiffness parameters were analysed. The distensibility coefficient (DC) did not show significant changes during heat provocation and extremity compression, while DC’s stability seemed to be acceptable. The same stability of carotid–femoral pulse wave velocity (PWV) was detected with ultrasound measurement (5.43 ± 0.79, 5.32 ± 0.86 and 5.28 ± 0.77, with p = 0.38, p = 0.27 and p = 0.76, respectively) with excellent intersession variability (intraclass correlation coefficient of 0.90, 0.88 and 0.91, respectively). However, the oscillometric PWV (oPWV) did change significantly between the heating and outer compression phase of the study (7.46 ± 1.37, 7.10 ± 1.18 and 7.60 ± 1.21, with p = 0.05, p = 0.68 and p < 0.001, respectively), the alteration of which is closely related to wave reflection, represented by the changes in reflection time. Our results indicate the good stability of directly measured elastic parameters such as DC and PWV, despite the extreme modulation of peripheral resistance. However, the oscillometric, indirectly detected PWV might be altered by physical interventions, which depend on wave reflection. The effective modulation of wave reflection was characterized by changes in the augmentation index, detected using both oscillometry and applanation tonometry. Thus, the environment during oscillometric measurement should be rigorously standardized. Furthermore, our results suggest the dynamic nature of the reflection point, rather than being a fixed anatomical point, proposed previously as aortic bifurcation. Full article
(This article belongs to the Special Issue Advance in the Diagnostic of Atherosclerosis)
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