Diagnosis and Management of Liver Cirrhosis and Portal Hypertension: 2nd Edition

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".

Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 1554

Special Issue Editors


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Guest Editor
Department of Gastroenterology, Hepatology and Clinical Nutrition, University Hospital Dubrava, University of Zagreb School of Medicine, Zagreb, Croatia
Interests: liver cirrhosis; liver diseases; cirrhosis; liver
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Guest Editor
Clinical Center, Institute of Gastroenterology 98, University of Debrecen, Nagyerdei blv., H-4032 Debrecen, Hungary
Interests: inflammatory bowel disease; ulcerative colitis; liver cirrhosis; gastrointestinal diseases; liver diseases; cirrhosis; liver failure; liver diseases and immunology

Special Issue Information

Dear Colleagues,

Chronic liver diseases impose a significant health burden worldwide, especially when they reach the stage of cirrhosis and portal hypertension. Age-standardised death rates from liver cirrhosis have declined over the last three decades in most regions of the world, most likely as a result of expanding knowledge and better healthcare; this, however, is except for Eastern Europe and Central Asia, which are facing elevated rates of heavy alcohol consumption. In the same period, the absolute number of deaths caused by cirrhosis increased by nearly 50%, representing 2.4% of all deaths in 2017, most likely reflecting the expansion of the world’s population and unmet needs in the field. Despite available vaccines and/or medications, viral hepatitis remains a challenging issue, and non-alcoholic fatty liver disease is becoming the leading cause of liver-related morbidity with multisystemic implications. The early identification, precise diagnosis, and prognostic stratification of this malady represent the most important steps towards the successful treatment and improved outcomes of patients with liver disease. The diagnostic landscape in hepatology has significantly changed, evolving from classical invasive methods, such as liver biopsy and hepatic venous pressure gradient measurements, to sophisticated non-invasive tools encompassing biochemistry, various “omics” approaches, and a myriad of ultrasound and magnetic resonance-based methods that are likely to be further enhanced by artificial intelligence. These steps forward in the diagnostic arena have been followed by equally exciting advances in therapeutic approaches, with novel compounds and devices having been introduced and others waiting to be evaluated and applied in clinical practice. The aim of this Special Issue of Diagnostics is to collate the current knowledge and apply it to cutting-edge research in the diagnosis and treatment of liver cirrhosis and portal hypertension, thus contributing to the global efforts to fight against these devastating conditions.

Prof. Dr. Ivica Grgurević
Prof. Dr. Mária Papp
Guest Editors

Manuscript Submission Information

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Keywords

  • liver cirrhosis
  • portal hypertension
  • esophageal varices
  • ascites
  • acute on chronic liver failure
  • liver fibrosi
  • liver steatosis
  • liver biopsy
  • proteomics in cirrhosis and portal hypertension
  • genomics in cirrhosis and portal hypertension
  • liver ultrasound
  • liver elastography
  • steatosis quantification
  • non-invasive methods
  • imaging in cirrhosis and portal hypertension
  • magnetic resonance elastography
  • contrast-enhanced ultrasound in cirrhosis and portal hypertension
  • machine-based learning in cirrhosis and portal hypertension
  • artificial intelligence in cirrhosis and portal hypertension
  • treatment of cirrhosis and portal hypertension

Published Papers (1 paper)

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Research

14 pages, 1488 KiB  
Article
The Value of Neutrophil-to-Lymphocyte Ratio to Identify Bacterial Infection and Predict Short-Term Mortality in Patients with Acutely Decompensated Cirrhosis
by Tamás Janka, Dávid Tornai, Mária Papp and Zsuzsanna Vitális
Diagnostics 2023, 13(18), 2954; https://doi.org/10.3390/diagnostics13182954 - 14 Sep 2023
Cited by 1 | Viewed by 1330
Abstract
Liver cirrhosis patients are highly susceptible to infections, affecting survival, but current parameters for detecting infection are not reliable enough in this population. We investigated the ability of white blood cell (WBC), ∆WBC, neutrophil and ∆neutrophil counts, neutrophil-to-lymphocyte (NLR) and ∆NLR ratios and [...] Read more.
Liver cirrhosis patients are highly susceptible to infections, affecting survival, but current parameters for detecting infection are not reliable enough in this population. We investigated the ability of white blood cell (WBC), ∆WBC, neutrophil and ∆neutrophil counts, neutrophil-to-lymphocyte (NLR) and ∆NLR ratios and C-reactive protein (CRP) and procalcitonin (PCT) levels to identify infection and predict short-term mortality in liver cirrhosis patients. We recruited 233 patients with liver cirrhosis hospitalized with acute decompensation (AD) who had an outpatient visit within 1 month (baseline laboratory data) and followed them for 90 days. Difference between laboratory values at baseline and the AD episode was defined as delta (∆) values of the parameters. Delta values did not increase the diagnostic and predictive ability of investigated parameters. The CRP level was found to be the best diagnostic marker for infection in patients with cirrhosis. However, NLR seems to be superior for short-term mortality prediction, better than the WBC count. Distinguishing inflammations of different origin is a remaining clinical challenge in acutely decompensated cirrhosis. Based on our results, NLR might be more suitable for predicting short-term mortality in patients with AD than the WBC count currently included in the CLIF-C AD score. Full article
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