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Diagnostics
Special Issues
Trends and Diagnosis of Autoimmune Diseases
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Trends and Diagnosis of Autoimmune Diseases

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: 31 August 2026 | Viewed by 826

Special Issue Editors

Prof. Dr. Abdulla Watad

E-Mail Website
Guest Editor
Department of Medicine B, Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Ramat Gan 5262100, Israel
Interests: comorbidities of ankylosing spondylitis; early diagnosis of ankylosing spondylitis; new bone formation; prevention of psoriatic arthritis; enthesitis and enthesopathy
Special Issues, Collections and Topics in MDPI journals
Dr. Yonatan Shneor Patt

E-Mail Website
Guest Editor Assistant
Internal Medicine B, Sheba Medical Centre, Ramat Gan 5262000, Israel
Interests: osteoporosis; autoimmune diseases

Special Issue Information

Dear Colleague,

Autoimmune diseases are a heterogeneous group of disorders driven by immune dysregulation and self-reactivity, presenting major diagnostic and clinical challenges. This Special Issue, “Trends and Diagnosis of Autoimmune Diseases,” aims to highlight advances in the detection, classification, and understanding of autoimmune conditions. We welcome contributions focused on innovative diagnostic tools, biomarkers, and imaging methods, as well as studies exploring emerging trends in incidence, presentation, and disease progression. A particular emphasis will be placed on the epidemiologic and clinical interplay between autoimmune diseases and comorbid conditions such as cardiovascular disease, malignancy, and other immune- and inflammation-mediated disorders. Understanding these associations may enhance our ability to recognize underlying autoimmune mechanisms and improve diagnostic accuracy. We invite original research, comprehensive reviews, and well-documented case reports that address current gaps and drive forward diagnostic and clinical practice in autoimmunity.

Prof. Dr. Abdulla Watad
Guest Editors

Dr. Yonatan Shneor Patt
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • autoimmunity
  • diagnosis
  • biomarkers
  • comorbidities
  • epidemiology
  • metabolic syndrome
  • autoinflammatory conditions
  • psoriasis
  • cardiovascular disease

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

15 pages, 721 KB  
Article
Increased Risk of Incident Uveitis Among Patients with Psoriasis: A Nationwide Population-Based Cohort Study
by Scott Ehrenberg, Yoav Elizur, Niv Ben-Shabat, Paula David, Kassem Sharif, Yossef S. Bernstein, Ibrahim Abu Hilwe, Arnon D. Cohen, Abdulla Watad, Howard Amital and Yonatan Shneor Patt
Diagnostics 2026, 16(4), 627; https://doi.org/10.3390/diagnostics16040627 - 21 Feb 2026
Viewed by 433
Abstract
Background: Psoriasis is a chronic systemic inflammatory disease with established extra-cutaneous manifestations. While the association between uveitis and spondyloarthritis (SpA)-related disorders is well recognized, the incident risk of uveitis among broader psoriasis populations remains inadequately defined due to methodological limitations and inconsistent findings [...] Read more.
Background: Psoriasis is a chronic systemic inflammatory disease with established extra-cutaneous manifestations. While the association between uveitis and spondyloarthritis (SpA)-related disorders is well recognized, the incident risk of uveitis among broader psoriasis populations remains inadequately defined due to methodological limitations and inconsistent findings across previous studies. We aimed to estimate the incidence of uveitis in a large, nationwide population-based cohort and identify specific clinical and treatment-related predictors of ocular inflammation. Methods: This retrospective cohort study utilised electronic health records from Clalit Health Services, Israel’s largest health maintenance organization (2002–2024). We identified 157,360 patients with dermatologist-confirmed psoriasis and 156,927 age- and sex-matched controls. The primary outcome was incident uveitis, with risk estimated using Cox proportional hazards models. Within the psoriasis cohort, multivariable logistic regression was employed to identify predictors of uveitis, ensuring appropriate temporal sequencing between psoriasis treatment exposure and outcome. Results: Over a median follow-up of 12.6 years, psoriasis was associated with a significantly higher risk of incident uveitis (adjusted Hazard Ratio [aHR] 1.80; 95% CI, 1.50–2.15). Stratified analysis revealed a graded risk pattern: mild psoriasis showed no increased risk (aHR 1.01; 95% CI, 0.91–1.13), whereas severe disease (aHR 1.59; 95% CI, 1.25–2.03) and concomitant SpA (aHR 2.21; 95% CI, 1.87–2.61) demonstrated markedly elevated risks. Within the psoriasis cohort, independent predictors included SpA, diabetes mellitus, systemic lupus erythematosus, and sarcoidosis. Exposure to biologics, particularly etanercept (OR 3.37; 95% CI, 2.42–4.54), was associated with higher odds of uveitis, potentially reflecting higher disease severity. Conclusions: Incident uveitis risk in psoriasis is primarily driven by the magnitude of systemic inflammatory burden, with the highest risk observed in severe disease and those with concomitant SpA. Clinicians should maintain heightened vigilance for ocular symptoms in these high-risk subgroups to ensure timely intervention. Full article
(This article belongs to the Special Issue Trends and Diagnosis of Autoimmune Diseases)
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