Hepatobiliary and Pancreatic Tumors: Advanced Diagnosis and Management

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 1383

Special Issue Editor


E-Mail Website
Guest Editor
Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA 30308, USA
Interests: hepatobiliary and pancreatic malignancies; pancreatic cancer; liver cancer

Special Issue Information

Dear Colleagues,

Hepatobiliary and pancreatic tumors present significant diagnostic and therapeutic challenges, and they continue to constitute a significant health burden with an ultimately poor prognosis for the most malignant tumors.

Over the last decade, remarkable progress has been made regarding the management of hepatobiliary cancers, particularly with the introduction of immune checkpoint inhibitor therapy. However, the same cannot be said for pancreatic cancer, although some advances have been made as more information concerning individualized treatments based on actionable molecular alterations, especially for KRAS wild-type metastatic alterations, have become available. More work must is necessary to refine the risk factors, optimize the screening modalities for premalignant lesions, enhance imaging for diagnosis, apply imaging modalities as biomarkers for disease prognosis and predicting treatment responses. Ultimately, these will enhance new drug development efforts and will translate into an improvement in our patients’ quality of life, alleviate suffering and improve overall survival.

This Special Issue seeks to assemble papers around the above themes. We are therefore looking forward to receiving original research articles, review articles and short communications in these areas. We welcome articles that explore the disparities in screening, diagnosis, treatment and biomarker development, and those that explore the role of artificial intelligence across the translational and clinical landscape of hepatobiliary and pancreatic tumors.

Dr. Olumide Gbolahan
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pancreatic malignacies
  • hepatocellular cancer
  • biliary tract cancer
  • cholangiocarcinoma
  • gallbladder cancer
  • diagnosis
  • disparities
  • AI
  • imaging
  • biomarkers
  • personalized medicine
  • next generation sequencing
  • screening

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Other

5 pages, 1056 KiB  
Interesting Images
Colloid Carcinoma Arising in an Intestinal-Type Intraductal Papillary Mucinous Neoplasm with High-Grade Dysplasia Appearing as Signet-Ring Cells of the Pancreas by Serial Pancreatic Juice Aspiration Cytology: A Case Report
by Mitsuhiro Tachibana, Takayoshi Hirota, Hideki Hamayasu, Yu Takeuchi, Kei Tsukamoto and Masahiro Matsushita
Diagnostics 2023, 13(19), 3123; https://doi.org/10.3390/diagnostics13193123 - 4 Oct 2023
Viewed by 1181
Abstract
We report a case of colloid carcinoma (CC) arising from an intestinal-type intraductal papillary mucinous neoplasm with high-grade dysplasia (IPMNHGD) of the pancreas, diagnosed with serial pancreatic juice aspiration cytological examination (SPACE). A rapidly growing intraductal papillary mucinous neoplasm (IPMN) in a 71-year-old [...] Read more.
We report a case of colloid carcinoma (CC) arising from an intestinal-type intraductal papillary mucinous neoplasm with high-grade dysplasia (IPMNHGD) of the pancreas, diagnosed with serial pancreatic juice aspiration cytological examination (SPACE). A rapidly growing intraductal papillary mucinous neoplasm (IPMN) in a 71-year-old Japanese man accelerated his hospitalization in our institute. Clinically, a large, ruptured pancreatic cyst was suspected. Cytologically, several mucin-positive signet-ring cells were scattered in the inflammatory, necrotic, or mucinous background. Signet-ring cells in cell block specimens were immunoreactive for MUC2, MUC5AC, maspin, S100P, and claudin-18. The final cytologic diagnosis was CC arising in an intestinal-type IPMNHGD with intraperitoneal penetration. The patient died two months after an explorative laparotomy. The cytologic diagnosis was achieved through SPACE, and the presence of signet-ring cells was characteristic. Anti-claudin-18.2-specific monoclonal antibody therapy will likely be used to treat patients with IPMNHGD in the future. This case highlights the diagnostic utility of SPACE, with particular emphasis on the characteristic presence of signet-ring cells. Furthermore, it anticipates the potential use of anti-claudin-18.2- specific monoclonal antibody therapy in the management of IPMNHGD patients. Full article
Show Figures

Figure 1

Back to TopTop