Diagnostics in Neurogastroenterology, Gastrointestinal Motility and Functional Disorders

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: closed (1 July 2023) | Viewed by 5239

Special Issue Editor

Gastroenterology and Hepatology Institute, Nazareth Hospital, Nazareth 16100, Israel
Interests: neurogastroenterology; motility disorders of the gastrointestinal tract; disorders of gut–brain interaction
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Important advances in the field of neurogastroenterology and motility have been achieved in recent years, including modern diagnostic testing, such as high-resolution oesophageal manometry (HRM), pH monitoring (catheter based with impedance and the wireless system), EndoFLIP planomety as well as the new protocols and methodologies in timed barium swallow (TBS). Notably, recent progress has also been reached in the study of the upper esophageal sphinctes (UES) by using HRM as well as new protocols of fluroscopy studies.

Moreover, developments in gastric motility testing and small intestinal testings as well as anorectal diagnostics are also available with the introduction of high-resolution anorectal manometry and three-dimensional manometry.

Additionally, better understanding of brain-gut relates conditions particularly in the era of microbiome and functional brain imaging. We believe that this special issue, is of paramount significance and relevance for shedding light on the recent advances on gastrointestinal functional and motility diagnostics.

Dr. Amir Mari
Guest Editor

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Keywords

  • achalasia
  • gastrointestinal motility
  • high resolution manometry
  • functional gastrointestinal disorders
  • dysphagia
  • EndoFLIP
  • gastroesophageal reflux disease
  • pH monitoring
  • fluroscopy
  • impedance
  • microbiome
  • irritable bowel syndrome
  • bloating
  • constipation
  • faecal incontinence

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Published Papers (2 papers)

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Editorial

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4 pages, 186 KiB  
Editorial
Diagnostics of Gastrointestinal Motility and Function: Update for Clinicians
by Amir Mari
Diagnostics 2022, 12(11), 2698; https://doi.org/10.3390/diagnostics12112698 - 4 Nov 2022
Viewed by 1290
Abstract
Disorders of gastrointestinal (GI) tract motility and function are prevalent in the general population and negatively affect quality of life [...] Full article

Other

Jump to: Editorial

8 pages, 1460 KiB  
Brief Report
Combined 3D Endoanal Ultrasound and Transperineal Ultrasound Improves the Detection of Anal Sphincter Defects
by Dan Carter, Edward Ram and Tal Engel
Diagnostics 2023, 13(4), 682; https://doi.org/10.3390/diagnostics13040682 - 11 Feb 2023
Cited by 3 | Viewed by 3509
Abstract
Introduction: Anal sphincter injury, mainly due to obstetric or iatrogenic etiology, is the most common cause of fecal incontinence (FI). Three-dimensional endoanal ultrasound (3D EAUS) is used for assessment of the integrity and the degree of anal muscle injury. However, 3D EAUS accuracy [...] Read more.
Introduction: Anal sphincter injury, mainly due to obstetric or iatrogenic etiology, is the most common cause of fecal incontinence (FI). Three-dimensional endoanal ultrasound (3D EAUS) is used for assessment of the integrity and the degree of anal muscle injury. However, 3D EAUS accuracy may be hampered by regional acoustic effects, such as intravaginal air. Therefore, our aim was to examine whether a combination of transperineal ultrasound (TPUS) and 3D EAUS would improve the accuracy of detection of anal sphincter injury. Methods: We prospectively performed 3D EAUS followed by TPUS in every patient evaluated for FI in our clinic between January 2020 and January 2021. The diagnosis of anal muscle defects was assessed in each ultrasound technique by two experienced observers that were blinded to each other’s assessments. Interobserver agreement for the results of the 3D EAUS and the TPUS exams was examined. A final diagnosis of anal sphincter defect was based on the results of both ultrasound methods. Discordant results were re-analyzed by the two ultrasonographers for a final consensus on the presence or absence of defects. Results: A total of 108 patients underwent ultrasonographic assessment due to FI (mean age 69 ± 13). Interobserver agreement for the diagnosis of tear on EAUS and TPUS was high (83%) with Cohen’s kappa of 0.62. EAUS confirmed anal muscle defects in 56 patients (52%), while TPUS confirmed them in 62 patients (57%). The final consensus agreed on the diagnosis of 63 (58%) muscular defects and 45 (42%) normal exams. The Cohen’s kappa coefficient of agreement between the results of the 3D EAUS and the final consensus was 0.63. Conclusions: The combination of 3D EAUS and TPUS improved the detection of anal muscular defects. The application of both techniques for the assessment of the anal integrity should be considered in every patient going through ultrasonographic assessment for anal muscular injury. Full article
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