Cardiovascular Diseases: Advances in Diagnosis and Management

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Clinical Diagnosis and Prognosis".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 1978

Special Issue Editor


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Guest Editor
Center for Cardiac Arrest Prevention, Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Health System, Los Angeles, CA, USA
Interests: cardiovascular diseases; predictive risk score; mortality; prognosis; artificial intelligence; machine learning; large language models

Special Issue Information

Dear Colleagues,

Cardiovascular disease remains the leading cause of mortality worldwide. With advancements in technology, molecular and genetic discoveries, and the development of novel pharmacological therapies, significant progress has been made in improving risk prediction, screening, diagnosis, and disease management. Artificial intelligence (AI) and machine learning (ML) have emerged as powerful tools in analyzing big data, optimizing imaging interpretation, and enhancing clinical decision-making. Simultaneously, the introduction of new medications has played a critical role in alleviating symptoms, reducing complications, and improving long-term outcomes for patients with cardiovascular disease.

This Special Issue aims to highlight innovations in both technological advancements and pharmacological therapies for cardiovascular disease, with a focus on their clinical applications in diagnosis, treatment, and long-term patient outcomes. We welcome submissions investigating the efficacy and safety of novel medications, as well as AI-driven approaches in disease diagnosis and management. Research areas may include, but are not limited to, the following:

  • AI- and ML-based predictive risk scoring for major adverse cardiovascular events, including sudden cardiac death, acute decompensated heart failure, acute coronary syndrome, lethal arrhythmias, and overall cardiovascular mortality;
  • AI integration in electronic devices, such as ECG machines, cardiac implantable electronic devices, and continuous ECG/vital signs monitoring systems;
  • AI-assisted interpretation of imaging results and its role in guiding interventional procedures such as PCI and catheter ablation;
  • the clinical efficacy and safety of novel pharmacological therapies in improving cardiovascular symptoms, reducing hospitalization rates, and enhancing survival outcomes;
  • the impact of the latest guideline-recommended treatments on mortality, disease progression, and quality of life in patients with cardiovascular disease.  

We look forward to receiving your contributions.

Dr. Thien Tan Tri Tai Truyen
Guest Editor

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Keywords

  • cardiovascular diseases
  • predictive risk score
  • mortality
  • prognosis
  • artificial intelligence
  • machine learning
  • large language models

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Published Papers (1 paper)

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Research

12 pages, 450 KB  
Article
Neutrophil Percentage/Albumin Ratio as an Independent Predictor of the No-Reflow Phenomenon in Patients with ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
by Ozkan Yavcin and Yucel Yilmaz
Diagnostics 2025, 15(20), 2609; https://doi.org/10.3390/diagnostics15202609 - 16 Oct 2025
Abstract
Objectives: Despite achieving a high rate of revascularization in epicardial coronary arteries with primary percutaneous coronary intervention (pPCI), suboptimal coronary reperfusion is encountered in more than half of patients. This condition, termed the ‘no-reflow phenomenon’ (NRP), has been associated with ventricular arrhythmias, [...] Read more.
Objectives: Despite achieving a high rate of revascularization in epicardial coronary arteries with primary percutaneous coronary intervention (pPCI), suboptimal coronary reperfusion is encountered in more than half of patients. This condition, termed the ‘no-reflow phenomenon’ (NRP), has been associated with ventricular arrhythmias, left ventricular dysfunction, impaired ventricular remodeling, myocardial reinfarction, and increased mortality. The neutrophil percentage/albumin ratio (NPAR) has been associated with the severity and prognosis of cardiovascular patients. The aim of this study is to investigate the relationship between NRP and NPAR in patients undergoing pPCI with a diagnosis of ST-elevation myocardial infarction (STEMI). Methods: A total of 758 patients diagnosed with STEMI and undergoing pPCI were included in this study. A total of 105 patients were detected to have NFP during pPCI (13.8%). Slow flow, such as thrombolysis in myocardial infarction (TIMI) 0, 1, or 2, observed in the distal part of the coronary artery after pPCI, was operationally defined as NRP. Reflow was defined as TIMI 3. NPAR was obtained by dividing the neutrophil percentage by albumin. Results: Statistically, there was a significant difference between the groups in terms of mean age, body mass index (BMI), and left ventricular ejection fraction (LVEF), which were higher in the NRP group [54 (45–62) vs. 60 (53–67), 26.5 (23.6–30.8) vs. 28.4 (26–31), and 39.2 ± 6.9 vs. 31.8 ± 5.1; p < 0.001, for all]. When laboratory parameters were examined between the two groups, white blood cell (WBC) count, neutrophil count, neutrophil percentage, C-reactive protein (CRP), neutrophil/lymphocyte ratio (NLR), NPAR and CRP/albumin ratio (CAR) levels were found to be statistically significantly higher in the patient group with NRP (p < 0.05). Multivariate analysis identified NPAR as an independent predictor of NRP (5.482, 3.254–9.234, p < 0.001). ROC analysis demonstrated that the best cutoff value of 18.45 for NPAR was to predict NRP with 80% sensitivity and 75% specificity (area under ROC curve = 0.826 (95% CI: 0.770–0.881), p < 0.001). Conclusions: We found that NPAR levels at admission were independently associated with the development of NRP pPCI in patients with STEMI. Full article
(This article belongs to the Special Issue Cardiovascular Diseases: Advances in Diagnosis and Management)
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