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Diagnostics
Special Issues
Diagnosis and Management of Cardiovascular Disorders
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Diagnosis and Management of Cardiovascular Disorders

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: 30 April 2025 | Viewed by 3581

Special Issue Editors

Dr. Michael Genuardi

E-Mail Website
Guest Editor
1. Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19123, USA
2. Division of Cardiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19123, USA
Interests: cardiology; cardiovascular disease
Dr. Juan Ortega-legaspi

E-Mail Website
Guest Editor
Penn Heart and Vascular Center, Perelman Center for Advanced MedicineEast Pavilion, 2nd Floor, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA
Interests: acute decompensated heart failure; circulatory assist devices; alcoholic cardiomyopathy; arrhythmogenic right ventricular dysplasia; arterial insufficiency
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Diagnosis and management of cardiovascular diseases are critical for maintaining heart health and preventing complications. Accurate diagnosis involves the use of various tests and examinations to assess the condition of the heart and blood vessels. These tests include electrocardiograms, echocardiograms, stress tests, and cardiac catheterization, which help identify the specific cardiovascular disease and its severity.

In some cases, interventions like angioplasty or bypass surgery may be necessary to restore blood flow to the heart. These procedures aim to open narrowed or blocked arteries and improve overall heart function. Rehabilitation programs are also crucial for supporting patients in recovering from cardiovascular events and maintaining their cardiovascular health.

In conclusion, a comprehensive approach to the diagnosis and management of cardiovascular diseases involves accurate diagnosis, lifestyle modifications, medication, interventions, rehabilitation, and patient education. By implementing these strategies, individuals can effectively manage their cardiovascular health and reduce the risk of complications.

Dr. Michael Genuardi
Dr. Juan Ortega-legaspi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiovascular disorders
  • heart failure
  • hemodynamics
  • cardiomyopathy

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Published Papers (3 papers)

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9 pages, 899 KiB  
Article
Polymorphism rs564398 of the ANRIL Gene as a Coronary-Artery-Disease-Associated SNP in Diabetic Patients of the Kazakh Population
by Alisher Aitkaliyev, Nazira Bekenova, Tamara Vochshenkova, Balzhan Kassiyeva and Valeriy Benberin
Diagnostics 2024, 14(21), 2412; https://doi.org/10.3390/diagnostics14212412 - 29 Oct 2024
Viewed by 765
Abstract
Background/Objectives. A cardiovascular complication of type 2 diabetes mellitus like coronary artery disease is influenced by a complex interplay between environmental, phenotypic, and genetic factors. The genetic mechanisms in the development of this pathology are not established. This study aims to evaluate the [...] Read more.
Background/Objectives. A cardiovascular complication of type 2 diabetes mellitus like coronary artery disease is influenced by a complex interplay between environmental, phenotypic, and genetic factors. The genetic mechanisms in the development of this pathology are not established. This study aims to evaluate the association of polymorphisms rs1011970, rs62560775, and rs564398 from the 9p21.3 locus with coronary artery disease in diabetic patients of the Kazakh population. Methods. A total of 343 people participated in the case-control study: the control group consisted of 109 people with type 2 diabetes and coronary artery disease, while the control group included 234 people. Genotyping was performed using real-time PCR. Statistical analysis was carried out using Chi-square methods and calculating odds ratios (OR) with 95% confidence intervals (CI). Results. According to the results, only the rs564398 polymorphism of the ANRIL gene was associated with coronary artery disease (p = 0.04). The CC genotype increased the risk of developing coronary artery disease by more than 1.5 times (1.62 (1.02–2.56)), whereas the TT genotype reduced the risk of coronary artery disease (0.39 (0.17–0.91)). The remaining polymorphisms, rs1011970 and rs62560775, were not associated with coronary artery disease. Conclusions. Thus, this research further elicits the association of the ANRIL gene with cardiometabolic disease. Full article
(This article belongs to the Special Issue Diagnosis and Management of Cardiovascular Disorders)
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15 pages, 8506 KiB  
Article
Comparative Efficacy and Safety of Self-Expandable vs. Balloon-Expandable Stent Grafts in Visceral Artery Aneurysm Management
by Reza Talaie, Pooya Torkian, Anthony Spano, Alireza Mahjoubnia, Siobhan M. Flanagan, Michael Rosenberg, Jian Lin, Jafar Golzarian and Preshant Shrestha
Diagnostics 2024, 14(15), 1695; https://doi.org/10.3390/diagnostics14151695 - 5 Aug 2024
Viewed by 1316
Abstract
Purpose: This study assesses the efficacy and safety of self-expandable (SE) versus balloon-expandable (BE) stent grafts for managing visceral artery aneurysms (VAAs), focusing on procedural success and complication rates. Materials and Methods: We conducted a retrospective analysis of VAA patients treated at our [...] Read more.
Purpose: This study assesses the efficacy and safety of self-expandable (SE) versus balloon-expandable (BE) stent grafts for managing visceral artery aneurysms (VAAs), focusing on procedural success and complication rates. Materials and Methods: We conducted a retrospective analysis of VAA patients treated at our institution from April 2006 to September 2021. The study reviewed patient demographics, aneurysm characteristics, treatment details, and outcomes, including endoleaks. Results: Among the 23 patients analyzed, splenic artery aneurysms represented 44% of cases. Fifteen patients were treated with balloon-expandable stent grafts (BE SGs), and eight patients were treated with self-expandable stent grafts (SE SGs). For saccular aneurysms, the average neck size was 10.10 ± 8.70 mm in the BE group versus 18.50 ± 3.40 mm in the SE group (p = 0.23), with an average sac size of 20.10 ± 18.9 mm in the BE group versus 15.60 ± 12.7 mm in the SE group (p = 0.16). The average sac-to-neck ratio was 1.69 ± 2.23 in the BE group versus 1.38 ± 0.33 in the SE group (p = 0.63). The BE group exhibited a significantly higher endoleak rate (60%) compared to the SE group (12.5%; p = 0.03). Conclusions: While further investigation is needed to fully assess the outcomes of stent graft treatment for VAAs, initial data show a significantly higher endoleak rate with BE SGs compared to SE SGs. The SE SGs may offer better outcomes due to their superior ability to conform to tortuous and mobile visceral arteries. Full article
(This article belongs to the Special Issue Diagnosis and Management of Cardiovascular Disorders)
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6 pages, 1963 KiB  
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Mistaken Identity: Misidentification of Other Vascular Structures as the Inferior Vena Cava and How to Avoid It
by Josh Zimmerman, Candice Morrissey, Nibras Bughrara and Yuriy S. Bronshteyn
Diagnostics 2024, 14(19), 2218; https://doi.org/10.3390/diagnostics14192218 - 4 Oct 2024
Viewed by 1113
Abstract
While point-of-care ultrasound (POCUS) of the inferior vena cava (IVC) is broadly perceived as having value in intravascular volume status assessment, this has not been borne out in large-scale meta-analyses containing heterogenous populations of acutely ill patients. While the limitations of IVC POCUS [...] Read more.
While point-of-care ultrasound (POCUS) of the inferior vena cava (IVC) is broadly perceived as having value in intravascular volume status assessment, this has not been borne out in large-scale meta-analyses containing heterogenous populations of acutely ill patients. While the limitations of IVC POCUS could be largely due to the complexity of the relationship between IVC appearance and volume status, another confounder not widely appreciated is the ease with which the aorta or right hepatic vein (RHV) can be mistaken for the IVC. While misidentification of the aorta as the IVC has been recognized elsewhere, misidentification of the RHV for the IVC has not and, in our experience, occurs frequently, even in the hands of experienced sonographers. We demonstrate how these errors occur and provide guidance on how to systematically avoid them. Full article
(This article belongs to the Special Issue Diagnosis and Management of Cardiovascular Disorders)
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