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Diagnostics
Special Issues
Recent Advances and Challenges in Gastrointestinal Endoscopy
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Recent Advances and Challenges in Gastrointestinal Endoscopy

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Biomedical Optics".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 1670

Special Issue Editor

Dr. Toshiro Iizuka

E-Mail Website
Guest Editor
Department of Gastroenterology, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan
Interests: endoscopic diagnosis and treatment; esophageal cancer; gastric cancer; pharyngeal cancer
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Recent advances in endoscopic devices have facilitated the diagnosis of gastrointestinal cancers. Once thought to have poor prognoses, it is now possible to diagnose esophageal and pancreatic cancers in their early stages. However, the number of early stage cancers detected is still low, and there is a need for innovative developments and methods to overcome this issue. This is an extremely important matter as it will eventually contribute to improving the prognosis of the disease as a whole. 

In this Special Issue, we welcome abstracts on endoscopic approaches with a particular focus on the diagnosis of early stage and superficial cancers, including IEE, AI-assisted techniques, EUS, ERCP, and endoscopic diagnostics combined with CT or MRI. We also welcome reports analyzing the risk factors involved in carcinogenesis, with an emphasis on cancer diagnoses.

We hope, in particular, that many clinicians will contribute to this Special Issue and find it useful in their daily practice.

Dr. Toshiro Iizuka
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • diagnosis at an early stage
  • endoscopy
  • precancerous lesion

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (2 papers)

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Research

8 pages, 1281 KiB  
Article
The Role of Small-Bowel Capsule Endoscopy in the Diagnostic Algorithm of Complicated Perianal Disease
by Irit Avni-Biron, Ervin Toth, Jacob E. Ollech, Artur Nemeth, Gabriele Wurm Johansson, Hagai Schweinstein, Reuma Yehuda Margalit, Uri Kopylov, Iris Dotan and Henit Yanai
Diagnostics 2024, 14(16), 1733; https://doi.org/10.3390/diagnostics14161733 - 9 Aug 2024
Viewed by 663
Abstract
Introduction: Complicated perianal disease (cPD) may be the sole presentation of Crohn’s disease (CD). The role of small-bowel capsule endoscopy (SBCE) in the diagnostic algorithm of cPD is unclear. We aimed to evaluate the role of SBCE as a diagnostic tool, in patients [...] Read more.
Introduction: Complicated perianal disease (cPD) may be the sole presentation of Crohn’s disease (CD). The role of small-bowel capsule endoscopy (SBCE) in the diagnostic algorithm of cPD is unclear. We aimed to evaluate the role of SBCE as a diagnostic tool, in patients with cPD, after a negative standard workup for CD. Methods: A multicenter, retrospective, cross-sectional study, in patients with cPD, and negative standard workup for CD (ileocolonoscopy and cross-sectional imaging), who underwent SBCE for suspected CD. Demographics, biomarkers, and the Lewis Score (LS) were recorded and analyzed. An LS ≥ 135 was considered a positive SBCE for diagnosing CD. Results: Ninety-one patients were included: 65 (71.4%) males; median age: 37 (29–51) years; cPD duration: 25.1 (12.5–66.1) months. Positive SBCE: 24/91 (26.4%) patients. Fecal calprotectin (FC) positively correlated with LS (r = 0.81; p < 0.001). FC levels of 100 µg/g and 50 µg/g had a sensitivity of only 40% and 55% to rule out small-bowel CD, with a negative predictive value (NPV) of only 76% and 80%, respectively. Conclusions: SBCE contributed to CD diagnosis in a quarter of patients with cPD after a negative standard workup. FC levels correlated with the degree of inflammation defined by the LS. However, the NPV of FC was low, suggesting that SBCE should be considered for patients with cPD even after a negative standard workup. Full article
(This article belongs to the Special Issue Recent Advances and Challenges in Gastrointestinal Endoscopy)
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11 pages, 953 KiB  
Article
Direct Single-Operator Cholangioscopy and Intraductal Ultrasonography in Patients with Indeterminate Biliary Strictures: A Single Center Experience
by Marco Sacco, Marcantonio Gesualdo, Maria Teresa Staiano, Eleonora Dall’Amico, Stefania Caronna, Simone Dibitetto, Chiara Canalis, Alessandro Caneglias, Federica Mediati, Rosa Claudia Stasio, Silvia Gaia, Giorgio Maria Saracco, Mauro Bruno and Claudio Giovanni De Angelis
Diagnostics 2024, 14(13), 1316; https://doi.org/10.3390/diagnostics14131316 - 21 Jun 2024
Viewed by 738
Abstract
The evaluation of biliary strictures poses a challenge due to the low sensitivity of standard diagnostic approaches, but the advent of direct single-operator cholangioscopy (DSOC) has revolutionized this paradigm. Our study aimed to assess the diagnostic performance of DSOC and DSOC-targeted biopsies, intraductal [...] Read more.
The evaluation of biliary strictures poses a challenge due to the low sensitivity of standard diagnostic approaches, but the advent of direct single-operator cholangioscopy (DSOC) has revolutionized this paradigm. Our study aimed to assess the diagnostic performance of DSOC and DSOC-targeted biopsies, intraductal ultrasound (IDUS), and standard brush cytology in patients with indeterminate biliary strictures (IBS). We reviewed patients who underwent advanced diagnostic evaluation for IBS at our endoscopy unit from January 2018 to December 2022, all of whom had previously undergone at least one endoscopic attempt to characterize the biliary stricture. Final diagnoses were established based on surgical pathology and/or clinical and radiological follow-up spanning at least 12 months. A total of 57 patients, with a mean age of 67.2 ± 10.0 years, were included, with a mean follow-up of 18.2 ± 18.1 months. The majority of IBS were located in the distal common bile duct (45.6%), with malignancy confirmed in 35 patients (61.4%). DSOC and IDUS demonstrated significantly higher accuracies (89.5% and 82.7%, respectively) compared to standard cytology (61.5%, p < 0.05). Both DSOC visualization and IDUS exhibited optimal diagnostic yields in differentiating IBS with an acceptable safety profile. Full article
(This article belongs to the Special Issue Recent Advances and Challenges in Gastrointestinal Endoscopy)
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