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Diagnostics
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Clinical Diagnosis of Otorhinolaryngology
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Clinical Diagnosis of Otorhinolaryngology

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: closed (31 May 2024) | Viewed by 1492

Special Issue Editors

Prof. Dr. Nina Gale

E-Mail Website
Guest Editor
Institute of Pathology, Faculty of Medicine, Korytkova 2, 1000 Ljubljana, Slovenia.
Interests: head and neck tumors; narrow band imaging; oropharyngeal neoplasms
Prof. Dr. Primož Strojan

E-Mail Website
Guest Editor
Department of Radiation Oncology, Institute of Oncology, Zaloška 2, 1000 Ljubljana, Slovenia
Interests: head and neck cancer; neuroendocrine neoplasms of the head and neck; melanoma and non-melanoma skin cancer; radiochemotherapy; radiotherapy-related toxicities
Special Issues, Collections and Topics in MDPI journals
Dr. Robert Šifrer

E-Mail Website
Guest Editor
Department of Otorhinolaryngology and Cervicofacial Surgery, University Medical Centre Ljubljana, Zaloška 2, 1000 Ljubljana, Slovenia
Interests: head and neck cancer; otorhinolaryngology

Special Issue Information

Dear Colleagues,

Among all cancers, head and neck cancer (HNC) ranks sixth in frequency. Due to the complexity of the head and neck region, HNC might cause many symptoms and clinical signs. Curative organ-sparing procedures encompass various irradiation or chemoradiotherapy protocols. In contrast, curative surgical treatment ranges from conservative surgery (i.e., endoscopic or open partial laryngectomy, endoscopic resection of sinonasal cancer, sleeve resection of the external auditory canal) to extensive surgical procedures (i.e., total laryngectomy, pharyngectomy, radical maxillectomy, temporal bone resection, complex reconstruction). The type of treatment is always multidisciplinary and has to be accepted by hosting multi-board discussions. It depends on the tumor (histology, extension, disfunction) and patient factors (general conditions, previous treatments, personal preferences). Therefore, the decision is not always straightforward and easy, but it is complex and well thought out.

The importance of the diagnostics of HNC cannot be over emphasized. With the advent of modern endoscopes, surgical microscopes, advanced imaging, enhanced endoscopy, enhanced contact endoscopy, advances in anesthesiology in recent decades, and artificial intelligence in recent years, diagnostics has made an important advancement. All these improvements lead to a more thorough delineation of the extension of cancer and adequate planning of therapy. Nevertheless, they serve our patients the most, after all.

Authors are kindly invited and encouraged to upload their original manuscripts about their experiences and research in the field of diagnostics in otorhinolaryngology in regard to HNC for this Special Issue of Diagnostics.

Prof. Dr. Nina Gale
Prof. Dr. Primož Strojan
Dr. Robert Šifrer
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • head and neck cancer
  • otorhinolaryngology
  • symptoms and clinical signs

Published Papers (2 papers)

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13 pages, 2449 KiB  
Article
Incidence of Carotid Blowout Syndrome in Patients with Head and Neck Cancer after Radiation Therapy: A Cohort Study
by Jian-Lin Jiang, Joseph Tung-Chieh Chang, Chih-Hua Yeh, Ting-Yu Chang, Bing-Shen Huang, Pi-Shan Sung, Chien-Yu Lin, Kang-Hsing Fan, Yi-Chia Wei and Chi-Hung Liu
Diagnostics 2024, 14(12), 1222; https://doi.org/10.3390/diagnostics14121222 - 9 Jun 2024
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Abstract
Carotid blowout syndrome (CBS) is a rare yet life-threatening complication that occurs after radiation therapy (RT). This study aimed to determine the incidence of CBS in patients with head and neck cancer (HNC) undergoing contemporary RT and to explore potential discrepancies in the [...] Read more.
Carotid blowout syndrome (CBS) is a rare yet life-threatening complication that occurs after radiation therapy (RT). This study aimed to determine the incidence of CBS in patients with head and neck cancer (HNC) undergoing contemporary RT and to explore potential discrepancies in the risk of CBS between nasopharyngeal cancer (NPC) and non-NPC patients. A total of 1084 patients with HNC who underwent RT between 2013 and 2023 were included in the study. All patients were under regular follow-ups at the radio-oncology department, and underwent annual contrast-enhanced computed tomography and/or magnetic resonance imaging for cancer recurrence surveillance. Experienced neuroradiologists and vascular neurologists reviewed the recruited patients’ images. Patients were further referred to the neurology department for radiation vasculopathy evaluation. The primary outcome of this study was CBS. Patients were categorized into NPC and non-NPC groups and survival analysis was employed to compare the CBS risk between the two groups. A review of the literature on CBS incidence was also conducted. Among the enrolled patients, the incidence of CBS in the HNC, NPC, and non-NPC groups was 0.8%, 0.9%, and 0.7%, respectively. Kaplan–Meier analysis revealed no significant difference between the NPC and non-NPC groups (p = 0.34). Combining the findings for our cohort with those of previous studies revealed that the cumulative incidence of CBS in patients with HNC is 5% (95% CI = 3–7%) after both surgery and RT, 4% (95% CI = 2–6%) after surgery alone, and 5% (95% CI = 3–7%) after RT alone. Our findings indicate a low incidence of CBS in patients with HNC undergoing contemporary RT. Patients with NPC may have a CBS risk close to that of non-NPC patients. However, the low incidence of CBS could be a potentially cause of selection bias and underestimation bias. Full article
(This article belongs to the Special Issue Clinical Diagnosis of Otorhinolaryngology)
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6 pages, 1510 KiB  
Case Report
The Thyrohyoid Syndrome: Promoting Awareness with a Case Report and Systematic Review of the Literature
by Raphael Jeker, Linda März and Lukas Horvath
Diagnostics 2024, 14(12), 1227; https://doi.org/10.3390/diagnostics14121227 - 12 Jun 2024
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Abstract
Objective: Neck pain is commonly referred to an ENT specialist and can be caused by the little-known inflammatory condition of the lateral thyrohyoid ligament. The pathophysiology of this condition is believed to be inflammation subsequent to over-exertion or cervical trauma. Typically, patients present [...] Read more.
Objective: Neck pain is commonly referred to an ENT specialist and can be caused by the little-known inflammatory condition of the lateral thyrohyoid ligament. The pathophysiology of this condition is believed to be inflammation subsequent to over-exertion or cervical trauma. Typically, patients present with chronic unilateral neck pain. Elicitation of localized tenderness over the axis of the lateral thyrohyoid ligament on palpation is a key finding for its diagnosis. We present an unusual case with an acute course and subcutaneous inflammation and discuss its management in an effort to raise awareness for this often-misdiagnosed syndrome. Methods: A systematic literature research on PubMed was performed selecting patients with a definitive diagnosis of thyrohyoid syndrome or lateral thyrohyoid ligament syndrome. Results: We collected 54 cases from three studies. This condition is an important differential diagnosis for acute or chronic antero-lateral or unilateral neck pain. Conclusion: No specific radiological findings are defined and a CT scan is therefore not necessary for its diagnosis, but ultrasound is a useful tool to primarily assess any neck lesion. Once the diagnosis is made, a local infiltration of steroids is the most sustainable treatment option and relapse prevention. Full article
(This article belongs to the Special Issue Clinical Diagnosis of Otorhinolaryngology)
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