New Advance in Central and Peripheral Circulation in Diabetes
A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".
Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 2086
Special Issue Editor
2. Department of Clinical Medicine and The August Krogh Institute, NEXS, Copenhagen University, Copenhagen, Denmark
Interests: magnetic resonance imaging; heart failure; diabetes; physiology; diastolic dysfunction
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Even with modern treatments for hypercholesterolemia and hypertension, patients with diabetes still suffer from a significantly increased risk of heart failure (HF). Recent studies have documented that approximately 50% of patients with diabetes and HF suffer from HF with preserved ejection fraction (HFpEF). This prevalence is expected to increase in the near future. The precise mechanisms responsible for HFpEF in patients with DM, but also in elderly patients with hypertension and not necessarily diabetes, are still not well-elucidated. In diabetes, it has been conclusively shown that these patients (even before HFpEF has ensued) have increase myocardial fibrosis (in some cases even "islands of fibrosis"), left ventricle hypertrophy and significantly lowered maximally attainable myocardial blood flow. Focus has been on the hearts of patients with HFpEF, but it is increasingly acknowledged, that "a stiff peripheral circulation" may be at least partly to blame. Not only do patients with diabetes (and other variants of patients with HFpEF) often have hypertension and elevated total peripheral resistance, they often also have "stiff conductance arteries", which in itself probably increases the afterload for the left ventricle. Obviously conductance artery atheromatosis may be seen in diabetes, but patients with diabetes often also have conductance artery "media sclerosis" (previously known as Monckeberg medial calcific sclerosis).
This Special Issue in Diagnostics will focus on the peripheral circulation and its relation to cardiac function not only in patients with diabetes, but also other patient groups with increased risk of HFpEF. We will welcome all contributions, both reviews and original papers in this field, from animal models and from patient studies.
Dr. Per Lav Madsen
Guest Editor
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Keywords
- diabetes
- heart failure with preserved ejection fraction
- heart failure
- cardiac hypertrophy
- non-invasive imaging
