Biomarkers in Osteoarthritis-Volume 2

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: closed (28 February 2023) | Viewed by 1977

Special Issue Editor


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Guest Editor
Department of Clinical Medicine, Aalborg University, 9220 Aalborg, Denmark
Interests: biomarkers; knee; osteoarthritis; sports medicine; arthroscopy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

There is an increasing incidence and prevalence of osteoarthritis due to the increasing population, increasing age, increasing BMI, and increasing multi-morbidity. Pain without cause for more than three months and degenerative changes on MRI indicate early osteoarthritis before degenerative changes are obvious on X-ray. Based on the accurate diagnosis and risk-benefit stratification it is essential to decide when to treat and to avoid overload on health costs.

Biomarkers are different indicators of physiological changes or disease processes and include physical, functional, and biochemical indicators. They provide information in determining or predicting disease prognosis, response to therapy, adverse events, interactions, and risks. There are a huge number of biomarkers in use, making it difficult to decide which biomarkers to use in osteoarthritis. Further, it may be a challenge to evaluate the reliability, validity, and responsiveness of a biomarker.

This calls for better, precise, and easy biomarkers to decide the optimal treatment at the right time, to follow up on treatment, and to perform a useful follow-up.

This Special Issue aims to gather a collection of cutting-edge research on the different types of biomarkers to improve decision-making. The aim is to publish original discoveries within osteoarthritis from all medical and biomedical disciplines. The scope is to provide what is new and what is the trend in biomarkers in relation to osteoarthritis.

We welcome submissions on, but not limited to, the following topics within osteoarthritis:

  • Biochemical;
  • Proteomics;
  • Molecular biology;
  • Scoring;
  • Functional;
  • Diagnostic;
  • Prognostic;
  • Predictor;
  • Outcome;
  • Patient-reported outcome;
  • Pathophysiology.

Prof. Dr. Sten Rasmussen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

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Published Papers (1 paper)

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Research

12 pages, 439 KiB  
Article
Prognostic Factors Related to Clinical Response in 210 Knees Treated by Platelet-Rich Plasma for Osteoarthritis
by Clément Chopin, Marion Geoffroy, Lukshe Kanagaratnam, Claire Dorilleau, Fiona Ecarnot, Renaud Siboni and Jean-Hugues Salmon
Diagnostics 2023, 13(4), 760; https://doi.org/10.3390/diagnostics13040760 - 17 Feb 2023
Cited by 5 | Viewed by 1563
Abstract
Many studies have shown the effectiveness of platelet-rich plasma (PRP) in the treatment of knee osteoarthritis. We aimed to determine the factors associated with good or poor response to PRP injections in knee osteoarthritis. This was a prospective observational study. Patients with knee [...] Read more.
Many studies have shown the effectiveness of platelet-rich plasma (PRP) in the treatment of knee osteoarthritis. We aimed to determine the factors associated with good or poor response to PRP injections in knee osteoarthritis. This was a prospective observational study. Patients with knee osteoarthritis were recruited from a university hospital. PRP was injected twice at a one-month interval. Pain was assessed on a visual analog scale (VAS) and function was assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Radiographic stage was collected and defined according to the Kellgren–Lawrence classification. Patients were classified as responders if they met the OMERACT-OARSI criteria at 7 months. We included 210 knees. At 7 months, 43.8% were classified as responders. Total WOMAC and VAS were significantly improved between M0 and M7. Physical therapy and a heel–buttock distance >35 cm were the two criteria associated with poor response at M7 by multivariate analysis. Pain VAS at M7 appeared to be lower in patients with osteoarthritis for less than 24 months. No adverse effects were reported. PRP treatment in knee osteoarthritis appears to be well-tolerated and effective, even in patients who reacted poorly to hyaluronic acid. Response was not associated with radiographic stage. Full article
(This article belongs to the Special Issue Biomarkers in Osteoarthritis-Volume 2)
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