Neurological Diseases: Novel Biomarkers for Diagnosis and Management

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Clinical Diagnosis and Prognosis".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 691

Special Issue Editor


E-Mail Website
Guest Editor
Neuroscience Research Center, Department of Medical and Surgical Sciences, University “Magna Graecia”, 88100 Catanzaro, Italy
Interests: biomarkers; neuroscience; laboratory medicine clinical diagnostics

Special Issue Information

Dear Colleagues,

This Special Issue focuses on the latest findings on novel biomarkers for the diagnosis and management of neurological diseases. The diagnosis of neurological disorders commonly relies on clinical assessment. However, symptoms may be subtle, especially at the early stages, and different pathologies may show overlapping symptoms. Moreover, different diseases with similar symptoms as well as distinct subtypes of the same disease may show differences in therapy response and outcome. In this context, biomarkers deriving from laboratory tests, multi-omics approaches, and neuroimaging techniques may be applied to the early detection of disease, differential diagnosis, and the prediction of disease evolution, collectively improving patient management. Overall, this Special Issue aims at proposing novel strategies for the diagnosis and management of neurological diseases to be applied in clinical practice.

Dr. Costanza Maria Cristiani
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomarkers
  • laboratory medicine
  • neuroimaging
  • neurological diseases
  • treatment
  • management
  • clinical diagnostics

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

15 pages, 305 KB  
Article
Early Detection of Cognitive Decline: Executive Functioning Index R4Alz-pc Predicts Memory-Related Concerns in Community Adults
by Eudokia Emmanouilidou, Despina Moraitou, Nikoleta Frantzi, Eleni Poptsi, Emmanouil Tsardoulias, Andreas L. Symeonidis, Georgia Papantoniou, Maria Sofologi, Elvira Masoura, Glykeria Tsentidou, Ioanna-Giannoula Katsouri and Magda Tsolaki
Diagnostics 2025, 15(17), 2158; https://doi.org/10.3390/diagnostics15172158 - 26 Aug 2025
Viewed by 546
Abstract
Background/Objectives: Early identification of preclinical Alzheimer’s disease (AD) is critically important. This study investigates whether early cognitive decline in preclinical AD can be detected through the executive functioning index R4Alz-pc by predicting memory-related worry and negative affect. Methods: A sample of 105 cognitively [...] Read more.
Background/Objectives: Early identification of preclinical Alzheimer’s disease (AD) is critically important. This study investigates whether early cognitive decline in preclinical AD can be detected through the executive functioning index R4Alz-pc by predicting memory-related worry and negative affect. Methods: A sample of 105 cognitively healthy, community-dwelling older adults (M = 59.25 years) completed the Multifactorial Memory Questionnaire (MMQ) and the R4Alz-pc index battery. Results: Lower performance on the R4Alz-pc index was significantly associated with increased negative affect related to memory. Mediation analysis indicated that memory-related worry mediated the relationship between executive dysfunction and negative affect. Conclusions: This study highlights the importance of early, objective cognitive assessment using easy-to-administer and non-invasive tools like the R4Alz-pc, enabling timely detection and intervention for preclinical AD. Such methods may reduce reliance on costly biomarker-based diagnostics. Full article
(This article belongs to the Special Issue Neurological Diseases: Novel Biomarkers for Diagnosis and Management)
Back to TopTop