Primary and Secondary Hypertension: Novelty in Diagnosis and Treatment
A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".
Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 4061
Special Issue Editor
Interests: primary hypertension; secondary hypertension; primary aldosteronism; obstructive sleep apnea; sleep-related disorders and the cardiovascular system
Special Issue Information
Dear Colleagues,
Systemic arterial hypertension affects around 30%–45% of adults worldwide and is the most prevalent modifiable risk factor for cardiovascular complications. It also called the ‘silent killer’ because, most of the time, it has no specific symptoms.
Hypertension is defined as ‘primary’ (or ‘essential’) when originates from an interaction of genetic and environmental factors without identification of a specific cause. However, in tertiary centers, the prevalence of ‘secondary’ hypertension is up to 35% of patients, in which high blood pressure derives from an underlying and potentially curable disease.
In the last few decades, enormous progress has been made in the workup and management of hypertension. In fact, the early detection of both forms of high blood pressure, along with the proper and targeted treatment, can significantly reduce the development of hypertension-mediated organ damage and the risk of cardiovascular complications, especially in patients with ‘difficult-to-treat’ or resistant hypertension. This form of hypertension is often associated with secondary causes, such as primary aldosteronism (PA) and obstructive sleep apnea (OSA), and it has been demonstrated that the diagnosis and treatment of these conditions is followed by a ‘resolution’ of resistant hypertension.
In terms of diagnosis, many novel techniques have emerged, especially for detecting the most common forms of secondary hypertension. New screening tools are being developed and validated, such as specific questionnaires for early disease detection (e.g., STOP-Bang questionnaire for OSA), as are new diagnostic instruments, such as for drug-induced sleep apnea. Changes in adrenal-vein sampling have been enlightening for PA.
Novel diagnostic methods have been illustrated for primary hypertension as well. For example, the latest European hypertension guidelines marked the superiority of 24-hour ambulatory blood pressure monitoring for diagnosis of hypertension, compared to office measurements. The discussion is now focused on the role of home blood pressure monitoring and the “unattended” automated office blood pressure measurements.
In this Special Issue, we encourage authors to submit original research papers or review articles presenting novel results on the following topics:
- Screening and diagnostic methods for ‘primary’ and ‘secondary’ hypertension.
- Diagnostic instruments for early identification of hypertension-mediated organ damage, including vascular remodeling, heart remodeling, renal impairment, cerebrovascular disease (e.g., measuring arterial stiffness, new markers of hypertension nephropathy).
- Recent findings in the treatment of hypertension: Are there new potential treatments? What about renal denervation and sympathetic activity modulation?
- New evidence on the workup (diagnosis and treatment) of resistant hypertension.
Dr. Valeria Bisogni
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- Primary hypertension
- Secondary hypertension causes
- Hypertension-mediated organ damage
- Resistant hypertension
