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Diagnostics
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Editorial Board Members’ Collection Series: Recent Advances in Optical Medical...
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Editorial Board Members’ Collection Series: Recent Advances in Optical Medical Imaging and Therapy Guidance

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Optical Diagnostics".

Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 6875

Special Issue Editors

Prof. Dr. Nicusor Iftimia

E-Mail Website
Guest Editor
Physical Sciences Inc., Andover, MA, USA
Interests: cancer diagnosis; cancer therapy; multimodal optical imaging; optical spectroscopy; biosensors
Dr. Qiwei Tian

E-Mail Website
Guest Editor
Shanghai Key Laboratory of Molecular Imaging, Jiading District Central Hospital Affiliated Shanghai University of Medicine and Health Sciences, Shanghai University of Medicine & Health Sciences, Shanghai, China
Interests: biomedical optical imaging; photothermal therapy; theranostics; bioactive materials

Special Issue Information

Dear Colleagues,

The main goal is to bring to the audience a series of papers presenting the latest advances in optical medical imaging and therapy guidance.

These are the main topics we consider to be of high interest:

  1. Ophthalmic imaging of early markers of diabetic retinopathy;
  2. New advances in skin cancer diagnosis and therapy guidance;
  3. Optical biopsy for cancer diagnosis and therapy guidance;
  4. New advances in optical neuroimaging;
  5. AI optical imaging in surgery guidance.

This Special Issue aims to present original research and review articles that summarize the state of the art, deal with open questions, and cover current aspects of optical medical imaging and therapy guidance in clinical medicine. On behalf of the Editorial Office, I would like to invite you to contribute your review articles and research papers concerning "Recent Advances in Optical Medical Imaging and Therapy Guidance" for peer review and possible publication.

Prof. Dr. Nicusor Iftimia
Dr. Qiwei Tian
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (4 papers)

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Research

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11 pages, 3320 KiB  
Article
High Sensitivity Singlet Oxygen Luminescence Sensor Using Computational Spectroscopy and Solid-State Detector
by Tiffany C. Yu, Steve J. Davis, Mark T. Scimone, John Grimble, Gopi Maguluri, Sanjay Anand, Cheng-En Cheng, Edward Maytin, Xu Cao, Brian W. Pogue and Youbo Zhao
Diagnostics 2023, 13(22), 3431; https://doi.org/10.3390/diagnostics13223431 - 12 Nov 2023
Viewed by 985
Abstract
This paper presents a technique for high sensitivity measurement of singlet oxygen luminescence generated during photodynamic therapy (PDT) and ultraviolet (UV) irradiation on skin. The high measurement sensitivity is achieved by using a computational spectroscopy (CS) approach that provides improved photon detection efficiency [...] Read more.
This paper presents a technique for high sensitivity measurement of singlet oxygen luminescence generated during photodynamic therapy (PDT) and ultraviolet (UV) irradiation on skin. The high measurement sensitivity is achieved by using a computational spectroscopy (CS) approach that provides improved photon detection efficiency compared to spectral filtering methodology. A solid-state InGaAs photodiode is used as the CS detector, which significantly reduces system cost and improves robustness compared to photomultiplier tubes. The spectral resolution enables high-accuracy determination and subtraction of photosensitizer fluorescence baseline without the need for time-gating. This allows for high sensitivity detection of singlet oxygen luminescence emission generated by continuous wave light sources, such as solar simulator sources and those commonly used in PDT clinics. The value of the technology is demonstrated during in vivo and ex vivo experiments that show the correlation of measured singlet oxygen with PDT treatment efficacy and the illumination intensity on the skin. These results demonstrate the potential use of the technology as a dosimeter to guide PDT treatment and as an analytical tool supporting the development of improved sunscreen products for skin cancer prevention. Full article
(This article belongs to the Special Issue Editorial Board Members’ Collection Series: Recent Advances in Optical Medical Imaging and Therapy Guidance)
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11 pages, 2979 KiB  
Article
Core Needle Biopsy Guidance Based on Tissue Morphology Assessment with AI-OCT Imaging
by Gopi Maguluri, John Grimble, Aliana Caron, Ge Zhu, Savitri Krishnamurthy, Amanda McWatters, Gillian Beamer, Seung-Yi Lee and Nicusor Iftimia
Diagnostics 2023, 13(13), 2276; https://doi.org/10.3390/diagnostics13132276 - 5 Jul 2023
Viewed by 1969
Abstract
This paper presents a combined optical imaging/artificial intelligence (OI/AI) technique for the real-time analysis of tissue morphology at the tip of the biopsy needle, prior to collecting a biopsy specimen. This is an important clinical problem as up to 40% of collected biopsy [...] Read more.
This paper presents a combined optical imaging/artificial intelligence (OI/AI) technique for the real-time analysis of tissue morphology at the tip of the biopsy needle, prior to collecting a biopsy specimen. This is an important clinical problem as up to 40% of collected biopsy cores provide low diagnostic value due to high adipose or necrotic content. Micron-scale-resolution optical coherence tomography (OCT) images can be collected with a minimally invasive needle probe and automatically analyzed using a computer neural network (CNN)-based AI software. The results can be conveyed to the clinician in real time and used to select the biopsy location more adequately. This technology was evaluated on a rabbit model of cancer. OCT images were collected with a hand-held custom-made OCT probe. Annotated OCT images were used as ground truth for AI algorithm training. The overall performance of the AI model was very close to that of the humans performing the same classification tasks. Specifically, tissue segmentation was excellent (~99% accuracy) and provided segmentation that closely mimicked the ground truth provided by the human annotations, while over 84% correlation accuracy was obtained for tumor and non-tumor classification. Full article
(This article belongs to the Special Issue Editorial Board Members’ Collection Series: Recent Advances in Optical Medical Imaging and Therapy Guidance)
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13 pages, 1010 KiB  
Article
Safety and Diagnostic Accuracy of the Transnasal Approach for Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration (EBUS-TBNA)
by Roberto Piro, Matteo Fontana, Eleonora Casalini, Laura Rossi, Maria Serena Simeone, Federica Ghinassi, Patrizia Ruggiero, Chiara Pollorsi, Sofia Taddei, Bianca Beghe’ and Nicola Cosimo Facciolongo
Diagnostics 2023, 13(8), 1405; https://doi.org/10.3390/diagnostics13081405 - 13 Apr 2023
Viewed by 2493
Abstract
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a safe and accurate diagnostic procedure used for investigating mediastinal pathologies. It is usually performed using an oral approach. The nasal route has been proposed but not extensively investigated. With the aim to report the use [...] Read more.
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a safe and accurate diagnostic procedure used for investigating mediastinal pathologies. It is usually performed using an oral approach. The nasal route has been proposed but not extensively investigated. With the aim to report the use of linear EBUS through the nasal route and compare its accuracy and safety with the oral one, we conducted a retrospective analysis of the subjects who underwent an EBUS-TBNA procedure at our center. From January 2020 to December 2021, 464 subjects underwent an EBUS-TBNA, and in 417 patients, EBUS was performed through the nose or mouth. Nasal insertion of the EBUS bronchoscope was performed in 58.5% of the patients. No difference between the two insertion routes was observed in terms of location or number of stations sampled per subject. Procedure complications were mild and similar between the two groups (10.2% for the nasal group vs. 9.8% for the oral group). Minor epistaxis occurred in five subjects in the nasal group. Comparing the two groups, the rates of adequate specimens were similar (95.1% vs. 94.8%), as were the proportions of diagnostic specimens (84% vs. 82%). In conclusion, the nasal route for EBUS-TBNA is a valid alternative to the oral one. Full article
(This article belongs to the Special Issue Editorial Board Members’ Collection Series: Recent Advances in Optical Medical Imaging and Therapy Guidance)
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Review

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12 pages, 608 KiB  
Review
Ultrasound Biomicroscopy as a Novel, Potential Modality to Evaluate Anterior Segment Ophthalmic Structures during Spaceflight: An Analysis of Current Technology
by Benjamin Soares, Joshua Ong, Daniela Osteicoechea, Cihan Mehmet Kadipasaoglu, Ethan Waisberg, Prithul Sarker, Nasif Zaman, Alireza Tavakkoli, Gianmarco Vizzeri and Andrew G. Lee
Diagnostics 2024, 14(6), 639; https://doi.org/10.3390/diagnostics14060639 - 18 Mar 2024
Viewed by 728
Abstract
Ocular health is currently a major concern for astronauts on current and future long-duration spaceflight missions. Spaceflight-associated neuro-ocular syndrome (SANS) is a collection of ophthalmic and neurologic findings that is one potential physiologic barrier to interplanetary spaceflight. Since its initial report in 2011, [...] Read more.
Ocular health is currently a major concern for astronauts on current and future long-duration spaceflight missions. Spaceflight-associated neuro-ocular syndrome (SANS) is a collection of ophthalmic and neurologic findings that is one potential physiologic barrier to interplanetary spaceflight. Since its initial report in 2011, our understanding of SANS has advanced considerably, with a primary focus on posterior ocular imaging including fundus photography and optical coherence tomography. However, there may be changes to the anterior segment that have not been identified. Additional concerns to ocular health in space include corneal damage and radiation-induced cataract formation. Given these concerns, precision anterior segment imaging of the eye would be a valuable addition to future long-duration spaceflights. The purpose of this paper is to review ultrasound biomicroscopy (UBM) and its potential as a noninvasive, efficient imaging modality for spaceflight. The analysis of UBM for spaceflight is not well defined in the literature, and such technology may help to provide further insights into the overall anatomical changes in the eye in microgravity. Full article
(This article belongs to the Special Issue Editorial Board Members’ Collection Series: Recent Advances in Optical Medical Imaging and Therapy Guidance)
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