Diagnostic Approach to Soft Tissue Tumors: From Morphology to Molecular Biology
A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".
Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 2113
Special Issue Editors
Interests: histological diagnoses of human tumors; immunohistochemistry; immunomarkers of malignant tumors; oncofetal expression of immunomarkers; pathological diagnoses of breast, soft tissue, thyroid, pediatric solid tumors
Special Issues, Collections and Topics in MDPI journals
Interests: clinical and molecular oncology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
A combined approach based on pathological examination and molecular analysis currently represents the diagnostic gold standard for the diagnosis of soft tissue tumors. Despite the fact that morphology and immunohistochemistry still represent the diagnostic gold standard of soft tissue tumors, molecular biology may be crucial to establish the correct diagnosis, especially when dealing with small biopsies and/or ambiguous morphological and immunohistochemical features. In this regard, the introduction of relatively novel ancillary methods, including real-time polymerase chain reaction (rt-PCR), fluorescence in situ hybridization (FISH), and next-generation sequencing (NGS), through which the molecular landscape of soft tissue neoplasms can be studied, has greatly improved diagnostic accuracy. These methods have helped to identify new “entity-defining” genetic alterations, some of which have been included to define many tumor entities. Based on this background, this Special Issue is devoted to the study of soft tissue tumors, based on both “conventional” histopathology and molecular biology. Original and review papers are particularly desired. Uncommon (in terms of unusal clinical context, unusal morphology/immunohistochemistry) and/or teaching case reports will also be considered for publication.
Prof. Dr. Gaetano Magro
Dr. Paolo G. Vigneri
Guest Editors
Manuscript Submission Information
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