Advances in Optical Coherence Tomography Angiography

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Optical Diagnostics".

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 4727

Special Issue Editors


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Guest Editor
Department of Engineering, Durham University, South Road, Durham, UK
Interests: biomedical image analysis with more emphasis on ocular data; deep learning; graph-based image analysis; time-frequency methods
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Guest Editor
Medical Image and Signal Processing Research Center, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Interests: medical image analysis and modeling; statistical (m-D) signal processing; sparse transforms; image restoration

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Guest Editor
David Geffen School of Medicine, Department of Ophthalmology, Stein Eye Institute, University of California Los Angeles, San Diego, CA, USA
Interests: artificial intelligence; macular OCT; macular OCTA; glaucoma progression; structure-function relationship in glaucoma; central visual field

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Guest Editor
Retina Ward, Farabi Eye Hospital Tehran University of Medical Sciences, Tehran, Iran
Interests: machine-learning and deep-learning; diabetic retinopathy; age-related macular degeneration; retinopathy of prematurity

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Guest Editor
Medical Image and Signal Processing Research Center, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Interests: biomedical signal and image processing; statistical modeling; OCT image modeling and processing; artificial intelligence for neuroimaging data analysis; statistical pattern recognition (SPR)

Special Issue Information

Dear Colleagues,

On behalf of the Diagnostics Editorial Team, we are delighted to present a Special Issue on the topic of Advances in Optical Coherence Tomography Angiography.

We are currently witnessing an evolution in retinal diagnostic imaging. In recent years, optical coherence tomography angiography (OCTA) has provided non-invasive, accurate and reliable evaluation of the microvascular morphology in superficial and deep layers of the retina and choroid. It also actualizes the assessment of retinochoroidal plexi and microvascularization in different diseases. As artificial intelligence becomes more popular, the potential role of OCTA in the early diagnosis and prognosis of a variety of diseases becomes evident. This Special Issue aims to highlight the advances in the use of OCTA as a new tool applied to various clinical practices in neurology and ophthalmology, as well as in systematic pathologies.

The accepted papers will describe new applications in these areas. This Special Issue accepts high-quality articles containing original research results and case reports, as well as review articles. Additionally, reports on using image processing and artificial intelligence in the analysis of OCTA images and retinal microvasculature are welcome. The results of advanced studies on OCTA imaging and data analysis will provide a background for future applications of this modality in finding new biomarkers and early diagnosis.

We look forward to receiving your contributions.

Dr. Rahele Kafieh
Dr. Hossein Rabbani
Dr. Vahid Mohammadzadeh
Dr. Elias Khalili Pour
Dr. Zahra Amini
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • optical coherence tomography angiography
  • early diagnosis
  • biomarkers
  • artificial intelligence
  • image processing

Published Papers (2 papers)

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Research

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14 pages, 7565 KiB  
Article
OCT Angiography in Noninfectious Uveitis: A Description of Five Cases and Clinical Applications
by Samyuktha Melachuri, Kunal K. Dansingani, Joshua Wesalo, Manuel Paez-Escamilla, Meghal Gagrani, Sarah Atta, Chad Indermill, José-Alain Sahel, Ken K. Nischal, Jay Chhablani and Marie-Hélène Errera
Diagnostics 2023, 13(7), 1296; https://doi.org/10.3390/diagnostics13071296 - 30 Mar 2023
Cited by 1 | Viewed by 1779
Abstract
Background: Optical coherence tomography angiography (OCTA) is a noninvasive imaging modality used to analyze the retinochoroidal vasculature and detect vascular flow. The resulting images can be segmented to view each vascular plexus individually. While fluorescein angiography is still the gold standard for the [...] Read more.
Background: Optical coherence tomography angiography (OCTA) is a noninvasive imaging modality used to analyze the retinochoroidal vasculature and detect vascular flow. The resulting images can be segmented to view each vascular plexus individually. While fluorescein angiography is still the gold standard for the diagnosis of posterior uveitis, it has limitations, and can be replaced by OCTA in some cases. Methods: This case series describes five patients with posterior noninfectious uveitis and their description by OCTA. Results: Cases included lupus retinopathy (n = 1) for which OCTA showed ischemic maculopathy as areas of flow deficit at the superficial and deep capillary plexus; choroidal granulomas (n = 1) with a non-detectable flow signal in the choroid; active punctate inner choroiditis and multifocal choroiditis (n = 1) with OCTA that showed active inflammatory chorioretinal lesions as non-detectable flow signals in choriocapillaris and choroid; dense type 2 inflammatory secondary neovascularization (n = 1) associated with active choroiditis; and acute posterior multifocal placoid pigment epitheliopathy (APMPPE) (n = 1) without flow abnormalities at the superficial and deep retinal plexuses but non-detectable flow at the levels of the choriocapillaris and choroid. Conclusions: Ophthalmologists can use OCTA to identify inflammatory changes in retinal and choroidal vasculature, aiding in the diagnosis, management, and monitoring of posterior uveitis. Full article
(This article belongs to the Special Issue Advances in Optical Coherence Tomography Angiography)
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Review

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15 pages, 979 KiB  
Review
OCT and OCT Angiography Update: Clinical Application to Age-Related Macular Degeneration, Central Serous Chorioretinopathy, Macular Telangiectasia, and Diabetic Retinopathy
by Lyvia Zhang, Elon H. C. Van Dijk, Enrico Borrelli, Serena Fragiotta and Mark P. Breazzano
Diagnostics 2023, 13(2), 232; https://doi.org/10.3390/diagnostics13020232 - 8 Jan 2023
Cited by 9 | Viewed by 2414
Abstract
Similar to ultrasound adapting soundwaves to depict the inner structures and tissues, optical coherence tomography (OCT) utilizes low coherence light waves to assess characteristics in the eye. Compared to the previous gold standard diagnostic imaging fluorescein angiography, OCT is a noninvasive imaging modality [...] Read more.
Similar to ultrasound adapting soundwaves to depict the inner structures and tissues, optical coherence tomography (OCT) utilizes low coherence light waves to assess characteristics in the eye. Compared to the previous gold standard diagnostic imaging fluorescein angiography, OCT is a noninvasive imaging modality that generates images of ocular tissues at a rapid speed. Two commonly used iterations of OCT include spectral-domain (SD) and swept-source (SS). Each comes with different wavelengths and tissue penetration capacities. OCT angiography (OCTA) is a functional extension of the OCT. It generates a large number of pixels to capture the tissue and underlying blood flow. This allows OCTA to measure ischemia and demarcation of the vasculature in a wide range of conditions. This review focused on the study of four commonly encountered diseases involving the retina including age-related macular degeneration (AMD), diabetic retinopathy (DR), central serous chorioretinopathy (CSC), and macular telangiectasia (MacTel). Modern imaging techniques including SD-OCT, TD-OCT, SS-OCT, and OCTA assist with understanding the disease pathogenesis and natural history of disease progression, in addition to routine diagnosis and management in the clinical setting. Finally, this review compares each imaging technique’s limitations and potential refinements. Full article
(This article belongs to the Special Issue Advances in Optical Coherence Tomography Angiography)
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