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Diagnostics
Special Issues
Role of PET Imaging in Therapy Response Assessment
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Role of PET Imaging in Therapy Response Assessment

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".

Deadline for manuscript submissions: closed (1 November 2021) | Viewed by 1991

Special Issue Editor

Prof. Dr. Federica Matteucci

E-Mail Website
Guest Editor
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Italy
Interests: PET/CT; molecular imaging; radiopharmaceuticals; prostate cancer; radiometabolic therapy

Special Issue Information

Dear Colleagues,

In the new era of precision medicine in oncology, diagnostic imaging methods are essential for the proper management of patients. In particular, the need for an effective and timely assessment of response to therapy is becoming more and more cogent with the aim of avoiding ineffective and often costly therapies for both patients and the healthcare system.

Traditionally, this assessment has been based on anatomic measurement of disease, such as CT assessment using Response Evaluation Criteria in Solid Tumors (RECIST). With the advent of PET/CT and its ability to detect therapy-related functional alterations in advance of morphologic changes, this method has been increasingly used in the assessment of response to therapy.

Moreover, following the recent development of new therapies (target-therapy, immunotherapy), the interest of the scientific world in the use of PET/CT in this field has greatly expanded.

In this Special Issue, we will contribute by collecting reviews or original data on the use of PET/CT in the evaluation of response to therapy in different oncological diseases using PET/CT with different tracers.

Prof. Dr. Federica Matteucci
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • PET/CT
  • FDG
  • immunotherapy
  • radiotherapy
  • response to therapy
  • Choline
  • PSMA

Published Papers (1 paper)

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Research

11 pages, 14694 KiB  
Article
Clinical and Radiological Features Predicting Intervertebral Autofusion after Successful Antibiotic Therapy in Pyogenic Vertebral Osteomyelitis
by Insu Seong, Eunjung Kong and Ikchan Jeon
Diagnostics 2021, 11(8), 1349; https://doi.org/10.3390/diagnostics11081349 - 27 Jul 2021
Cited by 3 | Viewed by 1577
Abstract
Background: Pyogenic vertebral osteomyelitis (PVO) is a bacterial infection involving the intervertebral disc, vertebral body, and paravertebral soft tissues. Damaged intervertebral structure is a major cause of persistent back pain even after successful antibiotic therapy, which can be improved by achieving autofusion or [...] Read more.
Background: Pyogenic vertebral osteomyelitis (PVO) is a bacterial infection involving the intervertebral disc, vertebral body, and paravertebral soft tissues. Damaged intervertebral structure is a major cause of persistent back pain even after successful antibiotic therapy, which can be improved by achieving autofusion or via additional surgical fixation. In this study, we analyzed the clinical and radiological features predicting intervertebral autofusion after successful antibiotic therapy in lumbar PVO. Methods: This study was retrospectively conducted with 32 patients (20 men and 12 women) diagnosed with lumbar PVO that was completely cured with no recurrences after antibiotic therapy. They were divided into two groups with (group A, n = 18) and without (group B, n = 14) intervertebral autofusion at six-month follow-up. Differences in back pain, blood inflammatory markers, and radiological features of PVO on simultaneous 18F-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging (18F-FDG-PET/MRI) of the intervertebral structure between the two groups were analyzed. Results: The mean duration of antibiotic therapy was 41.44 ± 14.21 (21–89) days. Group A showed a statistically higher erythrocyte sedimentation ratio (ESR; 59.28 ± 32.33 vs. 33.93 ± 18.76 mm/h, p = 0.014; normal range of ESR < 25), maximum standardized 18F-FDG uptake (SUVmax; 5.56 ± 1.86 vs. 3.98 ± 1.40, p = 0.013), and sustained extensive edematous changes on T2-weighted fat saturation (T2FS) MRI (p = 0.015) immediately after successful antibiotic therapy. However, no significant differences were observed in back pain, C-reactive protein, or the distribution of 18F-FDG uptake/contrast enhancement on 18F-FDG-PET/MRI (p > 0.05). Conclusions: Higher ESR and SUVmax of the intervertebral structure and sustained extensive edematous change on T2FS MRI immediately after successful antibiotic therapy are related with subsequent intervertebral autofusion, which should be carefully considered when assessing therapeutic response in PVO. Full article
(This article belongs to the Special Issue Role of PET Imaging in Therapy Response Assessment)
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