Current Perspectives and Gaps in the Diagnosis and Management of Rheumatic Diseases

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 1016

Special Issue Editor


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Guest Editor
Division of Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, NY, USA
Interests: rheumatology

Special Issue Information

Dear Colleagues,

The diagnosis and management of rheumatic diseases remain challenging due to the complexity of the immune system, heterogeneity in presentation, diagnostic dilemmas, and gaps in management. More than 100 rheumatic diseases have been identified, encompassing a spectrum from degenerative diseases such as osteoarthritis to prototypical autoimmune inflammatory disorders such as rheumatoid arthritis, systemic lupus erythematosus, vasculitis, spondyloarthritis, and others to auto-inflammatory syndromes. Rheumatic diseases affect up to one-third of the general population [1]. Furthermore, the impact on the quality of life, both in terms of morbidity and in the number of years lost, is tremendous [1]. In this Special Issue entitled "Current Perspectives and Gaps in the Diagnosis and Management of Rheumatic Diseases," we invite investigators to contribute original research or review articles that focus on the current understanding of rheumatic diseases, with a focus on various perspectives and gaps in their diagnosis and management.

References:

Salaffi F, Di Carlo M, Carotti M, Farah S, Ciapetti A, Gutierrez M. The impact of different rheumatic diseases on health-related quality of life: a comparison with a selected sample of healthy individuals using SF-36 questionnaire, EQ-5D and SF-6D utility values. Acta Biomed. 2019 Jan 15;89(4):541–557.

Dr. Vikas Majithia
Guest Editor

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Keywords

  • rheumatology
  • rheumatic diseases
  • inflammatory connective tissue diseases
  • rheumatoid arthritis
  • systemic lupus erythematosus
  • vasculitis
  • spondyloarthritis
  • scleroderma
  • osteoarthritis
  • current perspective
  • diagnosis
  • treatment
  • management

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Published Papers (1 paper)

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Research

11 pages, 269 KiB  
Article
Longitudinal Study of Patients with Connective Tissue Disease–Interstitial Lung Disease and Response to Mycophenolate Mofetil and Rituximab
by Yan Li, Sehreen Mumtaz, Hassan Z. Baig, Isabel Mira-Avendano, Benjamin Wang, Carlos A. Rojas, Justin T. Stowell, Elizabeth R. Lesser, Shalmali R. Borkar, Vikas Majithia and Andy Abril
Diagnostics 2024, 14(23), 2702; https://doi.org/10.3390/diagnostics14232702 - 30 Nov 2024
Viewed by 741
Abstract
Background/Objective: To investigate the effect of mycophenolate mofetil (MMF) and rituximab (RTX) on pulmonary function test (PFT) results in a mixed cohort of patients with connective tissue disease-associated interstitial lung disease (CTD-ILD), longitudinally followed up for 1 year in a single academic center. [...] Read more.
Background/Objective: To investigate the effect of mycophenolate mofetil (MMF) and rituximab (RTX) on pulmonary function test (PFT) results in a mixed cohort of patients with connective tissue disease-associated interstitial lung disease (CTD-ILD), longitudinally followed up for 1 year in a single academic center. Methods: Patients with CTD-ILD were identified in electronic medical records from 1 January 2009 to 30 April 2019. Prescribed MMF and RTX doses, dosage changes, and therapy plans were analyzed individually with improvement in PFT outcomes determined using multivariable linear regression models during 12-month follow-up. Results: Forty-seven patients with CTD-ILD, treated with MMF, RTX, or both, were included. Patients on combined MMF and RTX had worse PFT outcomes at baseline compared with patients on monotherapy. Substantial improvement was observed among all PFT outcomes from baseline to 12 months, regardless of medication dosage or therapy plans. The diffusing capacity of the lungs for carbon monoxide (DLCO) worsened by an average of 7.21 mL/(min*mmHg) (95% CI, 4.08–10.33; p < 0.001) among patients on RTX compared to combined therapy. Patients on higher doses of MMF at baseline experienced an average increase of 0.93 (95% CI, 0.04–1.82) units in DLCO from baseline to 6 months (p = 0.04) and a 2.79% (95% CI, 0.61–4.97%) increase in DLCO from 6 to 12 months (p = 0.02) within patients on concurrent RTX at 6-month follow-up. Conclusions: The treatment of CTD-ILD with MMF and/or RTX was associated with overall improvement in PFT outcomes. Combined therapy resulted in significant improvements in DLCO compared with monotherapy. Higher doses of MMF also provided greater improvements in DLCO. Full article
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