New Insights into Emergency Medicine

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 1136

Special Issue Editor


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Guest Editor
Department of Emergency Medicine, Hadassah Medical Center—Ein Kerem, Jerusalem 9112001, Israel
Interests: emergency medicine

Special Issue Information

Dear Colleagues,

Emergency medicine is a critical field that encompasses the prompt diagnosis, treatment, and management of patients in urgent medical situations, e.g., in a mass casualty incident. With the constant evolution of medical technologies and practices, there is a growing need for healthcare professionals to stay informed about the latest advancements in emergency medicine. This Special Issue aims to provide a platform for researchers, practitioners, and experts in this field to share new insights and innovations in the diagnosis of emergency medicine.

Dr. Evan Avraham Alpert
Guest Editor

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Keywords

  • emergency medicine
  • trauma
  • sepsis
  • acute coronary syndrome
  • mortality

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Published Papers (1 paper)

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Research

14 pages, 1025 KiB  
Article
Serial Examination of Platelet Function Tests Might Predict Prognosis of Patients with Acute Ischemic Stroke—A Cohort Study
by Hsin-Ju Ho, Li-Ching Wu and Yu-Wei Chen
Diagnostics 2024, 14(24), 2848; https://doi.org/10.3390/diagnostics14242848 - 18 Dec 2024
Viewed by 761
Abstract
Background: This study investigated whether point-of-care platelet function measurements could predict favorable outcomes in patients with acute ischemic stroke (AIS). Antiplatelet agents, such as aspirin, are known to reduce the risk of recurrent stroke by 20–30%. However, identifying nonresponders to therapy remains a [...] Read more.
Background: This study investigated whether point-of-care platelet function measurements could predict favorable outcomes in patients with acute ischemic stroke (AIS). Antiplatelet agents, such as aspirin, are known to reduce the risk of recurrent stroke by 20–30%. However, identifying nonresponders to therapy remains a clinical challenge. The study aimed to assess the prognostic value of serial Platelet Function Analyzer (PFA)-100 measurements and hematological ratios in AIS patients. Methods: A prospective cohort study was conducted on 212 AIS patients in Taiwan. Platelet function was assessed at baseline, week 2, and week 4 using PFA-100. The primary outcome was functional recovery, defined by a modified Rankin Scale (mRS) score of 0–3, at 1-month and 1-year. Subgroup analyses compared outcomes between pre- and post-aspirin administrations. Statistical analyses examined the association between changes in platelet function and clinical outcomes. Results: Difference in collagen and epinephrine (CEPI) measurements between baseline and week 2 was associated with favorable mRS scores (p < 0.001). A difference in CEPI closure time greater than 99 seconds was most predictive of a favorable outcome with an adjusted odds ratio of 11.859 (95% CI 2.318–60.669) at 1-month follow-up. Subgroup analyses revealed predictive value in pre-aspirin measurements at 1-month follow-up (p = 0.007). Conclusions: Serial PFA-100 measurements and hematological biomarkers, specifically changes in on-treatment CEPI closure times, may help predict favorable clinical outcome in AIS patients. These findings suggest that dynamic platelet function assessment could play a role in optimizing antiplatelet therapy in AIS management. Full article
(This article belongs to the Special Issue New Insights into Emergency Medicine)
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