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Diagnostics
Special Issues
Advances in the Diagnosis of Steatotic Liver Disease
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Advances in the Diagnosis of Steatotic Liver Disease

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 1340

Special Issue Editor

Dr. Helma Pinchemel Cotrim

E-Mail Website
Guest Editor
Department of Internal Medicine, School of Medicine, Federal University of Bahia, Salvador, BA, Brazil
Interests: steatotic liver disease; hepatocellular carcinoma; hepatotoxicity

Special Issue Information

Dear Colleagues,

Steatotic liver disease (SLD has emerged as the novel nomenclature for NAFLD, defined by the “A multi-society Delphi consensus statement on new fatty liver disease nomenclature". It includes sub classification such as metabolic-associated steatotic liver disease (MASLD); alcohol related SLD (SLD-ALD); specific etiology SLD (DILI; monogenetic diseases, miscellaneous); cryptogenic SLD: unknown causes.

Our knowledge of SLD, considered the most frequent liver disease today, has been enhanced in all aspects of the disease, including epidemiology, clinical profile, diagnosis, and treatment. Advances also have been reached in precision medicine, which soon will be integrated into SLD clinical practice. However, unmet practical needs are still present in most clinical aspects of this liver disease.

In this Special Issue, all relevant aspects of SLD examined through original research articles, reviews, short communications, case reports, and your contributions are welcome.

We look forward to your collaboration.

Dr. Helma Pinchemel Cotrim
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • steatotic liver disease—SLD
  • steatohepatitis
  • steatosis

Published Papers (1 paper)

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Research

18 pages, 2248 KiB  
Article
Mitochondrial Dysfunction in Peripheral Blood Mononuclear Cells as Novel Diagnostic Tools for Non-Alcoholic Fatty Liver Disease: Visualizing Relationships with Known and Potential Disease Biomarkers
by Emirena Garrafa, Agnese Segala, Marika Vezzoli, Emanuela Bottani, Barbara Zanini, Alice Vetturi, Renata Bracale, Chiara Ricci and Alessandra Valerio
Diagnostics 2023, 13(14), 2363; https://doi.org/10.3390/diagnostics13142363 - 13 Jul 2023
Cited by 2 | Viewed by 1159
Abstract
Non-alcoholic fatty liver disease (NAFLD) is a health emergency worldwide due to its high prevalence and the lack of specific therapies. Noninvasive biomarkers supporting NAFLD diagnosis are urgently needed. Liver mitochondrial dysfunction is a central NAFLD pathomechanism that changes throughout disease progression. Blood-cell [...] Read more.
Non-alcoholic fatty liver disease (NAFLD) is a health emergency worldwide due to its high prevalence and the lack of specific therapies. Noninvasive biomarkers supporting NAFLD diagnosis are urgently needed. Liver mitochondrial dysfunction is a central NAFLD pathomechanism that changes throughout disease progression. Blood-cell bioenergetics reflecting mitochondrial organ dysfunction is emerging for its potential applications in diagnostics. We measured real-time mitochondrial respirometry in peripheral blood mononuclear cells (PBMCs), anthropometric parameters, routine blood analytes, and circulating cytokines from a cohort of NAFLD patients (N = 19) and non-NAFLD control subjects (N = 18). PBMC basal respiration, ATP-linked respiration, maximal respiration, and spare respiratory capacity were significantly reduced in NAFLD compared to non-NAFLD cases. Correlation plots were applied to visualize relationships between known or potential NAFLD-related biomarkers, while non-parametric methods were applied to identify which biomarkers are NAFLD predictors. Basal and ATP-linked mitochondrial respiration were negatively correlated with triglycerides and fasting insulin levels and HOMA index. Maximal and spare respiratory capacity were negatively correlated with IL-6 levels. All the mitochondrial respiratory parameters were positively correlated with HDL-cholesterol level and negatively correlated with fatty liver index. We propose including blood cell respirometry in panels of NAFLD diagnostic biomarkers to monitor disease progression and the response to current and novel therapies, including mitochondrial-targeted ones. Full article
(This article belongs to the Special Issue Advances in the Diagnosis of Steatotic Liver Disease)
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