Diagnostics and Therapeutic Explorations in Aging

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Point-of-Care Diagnostics and Devices".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 1171

Special Issue Editor


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Guest Editor
Laboratory of Ophthalmology, Neuroscience Institute, Lithuanian University of Health Sciences, Medical Academy, Eiveniu 2, LT-50161 Kaunas, Lithuania
Interests: telomere length; risk factors; biomarkers; molecular mechanisms; age-related diseases
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Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to a Special Issue of Diagnostics focused on “Diagnostics and Therapeutic Explorations in Aging”.

Aging is a complex, multifactorial process that affects all living organisms, making it a compelling subject of study across disciplines such as biology, psychology, sociology, and philosophy. In this Special Issue, we will delve into the biological mechanisms underlying aging and age-related diseases and explore targeted therapies that may offer new insights. Key topics include cellular senescence, a process contributing to aging and age-related pathologies; telomere shortening, associated with aging and a significant focus in longevity research; mitochondrial dysfunction, leading to reduced energy production and increased oxidative stress; and genetic and epigenetic alterations. All these aspects hold potential for understanding cellular senescence and developing anti-aging interventions.

This Special Issue aims to bring together cutting-edge research and review articles that advance our understanding of the aging process and therapeutic strategies to combat age-related diseases. By fostering interdisciplinary collaboration, we hope to uncover novel diagnostic and therapeutic approaches that can improve health span and quality of life in the aging population.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

  • Cellular senescence and its role in aging;
  • Telomere biology and aging;
  • Mitochondrial dysfunction and oxidative stress;
  • Genetic and epigenetic factors in aging;
  • Biomarkers for aging and age-related diseases;
  • Novel therapeutic interventions targeting aging mechanisms;
  • Age-related diseases and their diagnostics;
  • Clinical trials and studies on anti-aging therapies.

We look forward to receiving your contributions to this exciting and impactful field of study.

Dr. Alvita Vilkevičiūtė
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • molecular markers
  • genetics
  • epigenetics
  • biochemistry
  • biomarkers
  • telomeres
  • age-related disease
  • senescence
  • mitochondrial dysfunction
  • immunogenetics

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Published Papers (1 paper)

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Research

12 pages, 2183 KiB  
Article
The Validity of a Smartphone-Based Application for Assessing Cognitive Function in the Elderly
by Jin-Young Min, Duri Kim, Hana Jang, Hyunjoo Kim, Soojin Kim, Seungbo Lee, Yae-eun Seo, Ye-jin Kim, Jong-yoon Kim and Kyoung-Bok Min
Diagnostics 2025, 15(1), 92; https://doi.org/10.3390/diagnostics15010092 - 3 Jan 2025
Viewed by 832
Abstract
Background/Objectives: The early detection of individuals at risk of cognitive impairment is a clinical imperative. With the recent advancement of digital devices, smartphone application-based cognitive assessment is considered a promising tool for cognitive screening and monitoring inside and outside the clinic. This study [...] Read more.
Background/Objectives: The early detection of individuals at risk of cognitive impairment is a clinical imperative. With the recent advancement of digital devices, smartphone application-based cognitive assessment is considered a promising tool for cognitive screening and monitoring inside and outside the clinic. This study examined whether a smartphone-based cognitive assessment, Brain OK, was valid for evaluating cognitive performance and identifying people at risk of cognitive impairment. Methods: We recruited 88 study participants aged over 60. They completed two cognitive tests with the Montreal Cognitive Assessment (MoCA), a validated paper-and-pencil cognitive screening tool, and Brain OK, a smartphone-based cognitive testing application. To examine convergent validity, we conducted analyses of Spearman correlations between MoCA and BrainOK, a Bland–Atman plot with regression analysis, and the area under the curve (AUC). Results: There was a significant positive association between Brain OK and the MoCA total score, with a coefficient of 0.9044 (SE = 0.057, t = 15.750, p < 0.001). The Bland–Altman plot represented a reasonable level of agreement between the two tests. We conducted the AUC analysis of Brain OK to compare the cognitively normal and impaired groups. The AUC value for the Brain OK score of 13.5 was the highest at 0.941. The sensitivity and specificity were 0.958 and 0.925, respectively. Conclusions: The smartphone app-based Brain OK test was feasible for assessing cognitive function and acceptable for identifying subjects with cognitive impairment. The results suggest Brain OK complements traditional in-person cognitive assessments and may help enhance cognitive health dialogue between doctors and patients. Full article
(This article belongs to the Special Issue Diagnostics and Therapeutic Explorations in Aging)
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