Clinical Features, Treatment, and Prognosis of Endocarditis

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 2946

Special Issue Editor


E-Mail Website
Guest Editor
Department of Cardiology, Cairo University, 6th Ahmed Mekhmer Street, El nozha El gedida District, Cairo, Egypt
Interests: infective endocarditis; cardiology; hypertension; heart failure; blood pressure; atherosclerosis; atrial fibrillation; cardiomyopathies; electrocardiography

Special Issue Information

Dear Colleagues,

Infective endocarditis is a life-changing infection. Since it was fully described by Dr. William Osler over a century now, and in spite of advances in antimicrobial therapy and cardiac surgery, the disease continues to be a devastating medical condition. Hospital mortality still exceeds 20% in many tertiary care centers, and delayed morbidity and mortality continue to exist, in spite of soaring cost of medical care. The numbers of patients with endocarditis on medicine and cardiology wards continues to increase.

The reasons for this are:

  • A wide variation of the clinical presentation, endocarditis may mimic any clinical presentation from a flu-like illness to renal colic or a brain tumor.
  • Increasing frequency and complexity of invasive healthcare procedures and implanted devices.
  • Increasing resistance to antimicrobial agents.
  • Sloppy infection control procedures.
  • Wide spread intravenous drug abuse.
  • Aging of the population.
  • Lack of early rapid diagnostic facilities in many primary healthcare facilities.
  • Increased detection of the disease, particularly since the advent of echocardiography.
  • Lack of multi-specialty team approach.

The procedures for diagnosis of endocarditis have also seen many breakthroughs in molecular identification, antibiotic resistance patterns, and imaging techniques. 

The scope of this volume is to shed light on the current difficulties in the timely diagnosis of infective endocarditis and its complications, and how making the best use of clinical skills, laboratory testing and imaging techniques can achieve a timely, accurate, and complete diagnosis of infective endocarditis.

Prof. Dr. Hussien Rizk
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • infective endocarditis
  • cardiology
  • hypertension
  • heart failure
  • blood pressure
  • atherosclerosis
  • atrial fibrillation
  • cardiomyopathies
  • electrocardiography
  • echocardiography
  • imaging techniques

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Review

14 pages, 858 KiB  
Review
Contemporary Features and Management of Endocarditis
by Shelby Comeaux, Kiara Jamison and Michele Voeltz
Diagnostics 2023, 13(19), 3086; https://doi.org/10.3390/diagnostics13193086 - 28 Sep 2023
Cited by 2 | Viewed by 1202
Abstract
Infective endocarditis is a rare but devastating disease. Morbidity and mortality rates have failed to improve despite new technological advances. The disease has evolved over time with new significant populations at risk—most notably those with prosthetic valves or implantable cardiovascular devices. These devices [...] Read more.
Infective endocarditis is a rare but devastating disease. Morbidity and mortality rates have failed to improve despite new technological advances. The disease has evolved over time with new significant populations at risk—most notably those with prosthetic valves or implantable cardiovascular devices. These devices pose new challenges for achieving a timely and accurate diagnosis of infection. While the modified Duke criteria is accepted as the gold standard for diagnosing native valve endocarditis, it has been shown to have significantly inferior sensitivity when it comes to identifying infections related to right-heart endocarditis, prosthetic valves, and indwelling cardiac devices. Additionally, prosthetic valves and cardiovascular implantable electronic devices can exhibit shadowing and artifact, rendering transthoracic echocardiography and transesophageal echocardiography results inconclusive or even normal. Having a keen awareness of the varying clinical presentations, as well as emerging valvular imaging modalities such as F-fluorodeoxyglucose cardiac positron-emission tomography plus computed tomography, promises to improve the evaluation and diagnosis of infective endocarditis. However, indications for appropriate use of these studies and guidance on modern clinical management are still needed. Full article
(This article belongs to the Special Issue Clinical Features, Treatment, and Prognosis of Endocarditis)
Show Figures

Figure 1

13 pages, 301 KiB  
Review
Exploring the Risk Factors and Possible Role of Calcium in Infective Endocarditis
by Yen-Shou Kuo and Yuan-Ming Tsai
Diagnostics 2023, 13(14), 2386; https://doi.org/10.3390/diagnostics13142386 - 17 Jul 2023
Cited by 1 | Viewed by 1426
Abstract
Infective endocarditis (IE) is a severe and potentially life-threatening infection that affects the endocardium, the inner lining of the heart chambers and valves. Although rare, it is a potentially fatal condition, with an incidence of 3–10 cases per 100,000 people per year in [...] Read more.
Infective endocarditis (IE) is a severe and potentially life-threatening infection that affects the endocardium, the inner lining of the heart chambers and valves. Although rare, it is a potentially fatal condition, with an incidence of 3–10 cases per 100,000 people per year in developed countries and a mortality rate of up to 30% within 30 days. Early identification and diagnosis are critical for improving outcomes. The diagnosis of IE typically involves a combination of biomarkers, blood cultures, and echocardiography. However, currently, there are no specific biomarkers for the early detection of IE. Given the lack of specific biomarkers for IE, serum calcium levels have been suggested to play a unique role in IE. There have been few articles on the correlation between serum calcium and IE, suggesting that patients with endocarditis and lower levels of serum calcium may have a poorer prognosis. Therefore, in this article, we focus on biomarkers of endocarditis and discuss the evidence showing serum calcium as a potential indicator of IE. Full article
(This article belongs to the Special Issue Clinical Features, Treatment, and Prognosis of Endocarditis)
Back to TopTop