Research on Microbial Protein Synthesis: 2nd Edition

Dear Colleagues,

Protein is among the most important kinds of biomolecules to have evolved in the process of sustaining life. These days, with the unleashing of their functional potential, proteins are becoming increasingly important to our world, serving as industrial biocatalysts, food and nutrients, therapeutic agents, biomaterial, and a variety of other uses. Additionally, an increasing number of protein-derived products are being developed for new application. To cope with this emerging trend, efficient and low-cost synthesis of protein is in high demand. Microbial synthesis is a prevalent way to produce proteins of broad interest that have numerous advantages. Microbes can synthesize a diverse array of proteins, both natural or unnatural, featuring intricate structures and long chains that surpass those achievable through chemical synthesis. Microbial cells are generally easier and more cost-effective to grow compared to other cells such as plant and animal cells. Despite these factors, microbial protein synthesis still faces challenges. Continuous efforts have been made to improve the production efficiency of microbial proteins and reduce cost. This includes fine-tuning the translation machinery, enhancing protein transport or secretion pathways, applying dynamic control to global metabolic fluxes, and developing cost-effective fermentation processes.

The goal of this Special Issue is to publish recent research results as well as review papers on synthesis machinery, fermentation production, function characterization, and product development of various proteins (e.g., enzyme, pharmaceutical protein, food ingredient, protein material) from microbial systems (e.g., bacterium, yeast, filamentous fungus, mushroom culture). Methodologies employed for the extraction and processing (cell-free extracts, phase separation, aggregation, etc.) of microbial proteins and the engineering of protein behaviours are also of interest.

Prof. Dr. Dong Liu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Fermentation is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• protein expression
• protein secretion
• molecular chaperone
• recombinant protein
• heterologous expression
• alternative protein
• precision fermentation
• continuous fermentation
• microbial cell factories