Molecular Design Breeding in Aquaculture

A special issue of Fishes (ISSN 2410-3888). This special issue belongs to the section "Genetics and Biotechnology".

Deadline for manuscript submissions: 30 April 2025 | Viewed by 520

Special Issue Editors


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Guest Editor
State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China
Interests: molecular breeding; goldfish; evolution; aquaculture; efficient breeding

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Guest Editor
Fisheries College, Hunan Agricultural University, Changsha 410128, China
Interests: aquatic animals; gene editing; selective and genetic breeding; innate immune regulation

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Guest Editor
Key Laboratory of Freshwater Animal Breeding, College of Fisheries, Ministry of Agriculture and Rural Affairs, Huazhong Agricultural University, Wuhan 430070, China
Interests: molecular breeding; gene edit; intermuscular bone; fish; development; omics; bone; gene function

Special Issue Information

Dear Colleagues,

In the burgeoning domain of aquaculture, the advent of precision molecular design breeding and bio-breeding technologies has positioned itself at the vanguard, heralding an epoch of unprecedented efficiency and specificity. This thematic issue is dedicated to the elucidation of the latest advances in the identification of key genes that govern the economically significant traits in aquatic species, leveraging multi-omics strategies such as resequencing and transcriptomics. These traits, which include growth, disease resistance, coloration, reproduction, sex control, and ploidy regulation, are paramount for the economic feasibility of aquaculture. We delve into the innovative development of molecular markers, gene editing, transgenic technologies, germline stem cell transplantation, and chromosomal engineering, which are pivotal for the expedited generation of superior germplasm. Concurrently, the research presented in this Issue also addresses the development of monosex and sterile breeding techniques, which are critical for mitigating the potential ecological risks associated with the application of gene editing and other precision molecular design breeding technologies. By integrating these cutting-edge strategies, this thematic issue aspires to provide a holistic understanding of the current state and future prospects of bio-breeding technologies in aquaculture. This endeavor is aimed not only at maximizing economic benefits but also at ensuring ecological sustainability, thereby contributing to the responsible advancement of the aquaculture industry.

Dr. Peng Yu
Dr. Shuting Xiong
Dr. ChunHong Nie
Guest Editors

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Keywords

  • molecular breeding
  • gene edting
  • sex control
  • transgenosis
  • molecular marker

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Published Papers (1 paper)

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Research

13 pages, 2280 KiB  
Article
RIOK1/2 Negatively Regulates the Antiviral Response by Targeting TBK1 in Yellow Catfish (Pelteobagrus fulvidraco)
by Kejun Liu, Jiayang Huang, Yuting Gui, Qian Li, Lei Zhang and Shuting Xiong
Fishes 2025, 10(1), 6; https://doi.org/10.3390/fishes10010006 - 27 Dec 2024
Viewed by 295
Abstract
The yellow catfish (Pelteobagrus fulvidraco) industry has expanded to a certain scale and is an important part of aquaculture in China, but frequent diseases have caused huge economic losses. Comprehending the fish’s immune mechanisms, particularly the regulation of the interferon (IFN) [...] Read more.
The yellow catfish (Pelteobagrus fulvidraco) industry has expanded to a certain scale and is an important part of aquaculture in China, but frequent diseases have caused huge economic losses. Comprehending the fish’s immune mechanisms, particularly the regulation of the interferon (IFN) response, is of paramount importance for future drug development and disease-resistant molecular breeding. Notably, the role of atypical protein kinases, such as the RIO kinase family, in immune regulation is poorly defined. Here, we investigated the roles of yellow catfish RIO kinases, PfRIOK1 and PfRIOK2, in modulating the IFN response through their interaction with PfTBK1, a key player in the RLR signaling pathway. Mechanically, PfRIOK1 and PfRIOK2 negatively regulate the IFN response by interacting with the RIO domains to target and degrade PfTBK1. Our findings reveal that the overexpression of PfRIOK1 and PfRIOK2 led to the decreased expression of IFN-related genes and enhanced viral replication in vitro. Additionally, PfRIOK1 and PfRIOK2 could inhibit PfTBK1-mediated antiviral responses in infected cells. These results suggest that PfRIOK1 and PfRIOK2 act as negative regulators of the IFN response in yellow catfish, providing new insights into the regulatory mechanisms of fish innate immunity and offering target molecules for molecular design breeding in aquaculture. Full article
(This article belongs to the Special Issue Molecular Design Breeding in Aquaculture)
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