Food Toxicology: Effects of Food Safety Hazards on Animals and Human Cells

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Food Toxicology".

Deadline for manuscript submissions: closed (22 November 2024) | Viewed by 1505

Special Issue Editors


E-Mail Website
Guest Editor
State Key Laboratory of Food Science and Resource, Nanchang University, Nanchang 330047, China
Interests: functional foods; dietary fiber; bioactive compounds; natural inhibitors; food toxicology

E-Mail Website
Guest Editor
State Key Laboratory of Food Science and Resource, Nanchang University, Nanchang 330047, China
Interests: bioactive phytochemicals; polysaccharides; sterols; acrylamide; furan; advanced glycation end products

Special Issue Information

Dear Colleagues,

Food safety hazards can lead to a variety of food-borne illnesses in humans, some of which are even life-threatening. During the raw material production, harvesting, processing, shipping, and storage of food, a variety of hazardous and poisonous substances, such as acrylamide, aflatoxins, and N-nitroso compounds, may be created and introduced. Nonetheless, the molecular mechanisms and targets of most hazards remain unclear. Detailed disclosure of the toxicity mechanism and bioavailability of food safety hazards is required. Animal models and cellular models are commonly used in the toxicological evaluation of food safety hazards. While animal models offer advantages such as short reproduction cycles and genetic manipulation, they are also limited by genetic background differences and ethical considerations. In contrast, in vitro cultured cellular models compensate for these drawbacks and reflect the organism's changes from a general to a detailed level. In-depth exploration of the effects of food safety hazards on animal or human cells and the related molecular mechanisms can provide a more accurate basis for control, standardization and revision of food safety.

Prof. Dr. Danfei Huang
Prof. Dr. Mingyue Shen
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Foods is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • food harzards
  • animals
  • human
  • cells
  • mechanism

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

22 pages, 1040 KiB  
Article
Oral Toxicity and Hypotensive Influence of Sericin-Derived Oligopeptides (SDOs) from Yellow Silk Cocoons of Bombyx mori in Rodent Studies
by Chainarong Tocharus, Virakboth Prum and Manote Sutheerawattananonda
Foods 2024, 13(21), 3505; https://doi.org/10.3390/foods13213505 - 1 Nov 2024
Viewed by 1227
Abstract
Sericin-derived oligopeptides (SDOs) from yellow silk cocoons exhibit antihypertensive and hypoglycemic properties in both in vitro and in vivo studies. This study investigated the acute toxicity of SDOs as a novel food for human consumption using female ICR mice and Wistar rats, as [...] Read more.
Sericin-derived oligopeptides (SDOs) from yellow silk cocoons exhibit antihypertensive and hypoglycemic properties in both in vitro and in vivo studies. This study investigated the acute toxicity of SDOs as a novel food for human consumption using female ICR mice and Wistar rats, as well as the chronic toxicity test on both sexes of Wistar rats. Clinical chemistry, hematology, and histopathological studies revealed that SDOs were safe for a single dose of 2000 mg kg1 body weight (BW) and daily oral administration of 50, 100, and 200 mg kg1 BW for six months. The chronic toxicity study additionally measured the rats’ systolic blood pressure (SBP) and blood sugar monthly as they slowly aged. In the 2nd month for male rats and the 4th month for both sexes, SDOs had a significant hypotensive effect on Wistar rats’ blood pressure, lowering it from 130 mmHg to a plateau at 110–115 mmHg. In contrast, the blood pressure of the control rats exceeded 140 mmHg after five months. Nonetheless, the hypoglycemic effect was not observed. Measurements of SBP and blood glucose in aged rats during chronic toxicity tests yielded insights beyond ordinary toxicity, including the health and fitness of the lab rats, perhaps resulting in novel discoveries or areas of study that justify the sacrifice of the animals’ lives. Full article
Show Figures

Figure 1

Back to TopTop