A Public Health View on Chronic Aging Diseases
A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Infectious Diseases, Chronic Diseases, and Disease Prevention".
Deadline for manuscript submissions: closed (31 October 2024) | Viewed by 2900
Special Issue Editors
Interests: methodology and statistics; especially new methodology approaches (machine learning in data from eHRs); aging diseases; multimorbidity; clinical immunology; integrated models of comorbidities
Interests: immunology; dermatology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
According to our current understanding of the aging process, chronic, low-grade inflammation is a major driver of aging and the development of age-related medical conditions. The main stimuli which trigger receptors of the innate immune system, initiating pro-inflammatory pathways, come from damaged or structurally changed tissues, disturbed gut microbiota, and metabolic challenges associated with changes in the body’s shape and glucose-mediated metabolism. The source of pro-inflammatory cytokines is also accumulated senescent tissue cells and lymphocytes which have lost their replicative capacity. In addition, chronic activation of the Th1/Th17 pro-inflammatory immune pathway may contribute to the maintenance of chronic inflammation. The dysfunctional endothelium of the microcirculation also plays an important role in inflammation augmentation, as it acts the place where immune and inflammatory cells are activated and dissipate to tissues. Environmental challenges, as well as pre-existing comorbidities, together with applied treatments, may accelerate aging processes. Changes in tissue structures and the replacement of functionally competent tissues with fibrotic tissues, as a consequence of immunologic and inflammatory reactions taking place in tissues and organs under aging conditions, lead to organ damage aggravation and the body’s overall functional decline. Many details of this complex network, from the macro-environmental level to the organ/tissue and microbiology levels, are poorly understood. It is difficult to validate the use of inflammatory markers for prediction purposes in clinical settings because of the intimate associations of these markers with the sociodemographic characteristics of the examined population and biomarkers indicating different disease pathways. By calling for papers for this Special Issue, we aim to seek clarification of this complex issue.
Prof. Dr. Ljiljana Trtica Majnarić
Prof. Dr. Martina Mihalj
Guest Editors
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Keywords
- aging of the immune system
- chronic inflammation
- tissue and organ damage
- age-related chronic medical conditions and comorbidities
- behavioral and environmental factors
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