Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
7.3
Journals
IJERPH
Special Issues
Multiple Environmental and Lifestyle Determinants of Asthma and Poor Asthma...
ijerph-logo
Submit to IJERPH Review for IJERPH Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Multiple Environmental and Lifestyle Determinants of Asthma and Poor Asthma Control

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Environmental Health".

Deadline for manuscript submissions: closed (31 January 2021) | Viewed by 14016

Special Issue Editors

Dr. Orianne Dumas

E-Mail Website
Guest Editor
INSERM, U1168, VIMA: Aging and chronic diseases, Epidemiological and public health approaches, and Univ Versailles St-Quentin-en-Yvelines, Villejuif, France
Interests: asthma; occupational exposures; early-life environment; chemical exposures; causal modelling
Dr. Raphaelle Varraso

E-Mail Website
Guest Editor
INSERM, U1168, VIMA: Aging and chronic diseases, Epidemiological and public health approaches, and Univ Versailles St-Quentin-en-Yvelines, Villejuif, France
Interests: asthma; diet; obesity; physical activity; smoking; causal modelling

Special Issue Information

Dear Colleagues,

The International Journal of Environmental Research and Public Health welcomes submissions for a Special Issue of the journal on determinants of asthma and poor asthma control, with a focus on environmental and lifestyle risk factors and their interplays.

Asthma is one of the most common chronic diseases of the airways in the world, affecting 273 million individuals. Asthma is influenced by many environmental (e.g., indoor allergens and irritants, air pollution, occupational exposures) and lifestyle (e.g., cigarette smoking, nutritional factors including obesity, physical activity, and diet) exposures. However, none of these factors taken individually explains the high level of asthma prevalence attained in industrial countries, suggesting complex interplay between asthma determinants. Currently, knowledge on asthma determinants and their interplays remains insufficient to develop efficient asthma prevention strategies.

Among patients with asthma, poor control of the disease has major consequences on health status, quality of life, and economic burden. Achieving and maintaining asthma control is thus a major goal in asthma management. However, asthma control is suboptimal in ~50% of adult patients. While asthma management recommendations mainly focus on treatment, the identification and avoidance of exposures contributing to poor asthma control are recognized as important steps in disease management. Nevertheless, few epidemiological studies have focused on determinants of asthma control.

This Special Issue welcomes original epidemiological research and review articles providing new insight on the multiple environmental and lifestyle factors that cause asthma or lead to uncontrolled asthma. We are particularly interested in research which may help in designing alternative public health primary and secondary prevention strategies that are effective in reducing asthma burden worldwide. The listed keywords suggest just a few of the many possibilities.

Dr. Orianne Dumas
Dr. Raphaelle Varraso
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Asthma
  • Asthma control
  • Epidemiology
  • Environmental exposures
  • Occupational exposures
  • Air pollution
  • Diet
  • Physical activity
  • Obesity
  • Indoor environment
  • Chemical exposures
  • Socioeconomic factors
  • Exposome
  • Causal modelling

Published Papers (4 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

16 pages, 1298 KiB  
Article
Proximity to Major Roads and Risks of Childhood Recurrent Wheeze and Asthma in a Severe Bronchiolitis Cohort
by Rachel D. Freid, Ying (Shelly) Qi, Janice A. Espinola, Rebecca E. Cash, Zahra Aryan, Ashley F. Sullivan and Carlos A. Camargo, Jr.
Int. J. Environ. Res. Public Health 2021, 18(8), 4197; https://doi.org/10.3390/ijerph18084197 - 15 Apr 2021
Cited by 9 | Viewed by 2262
Abstract
Air pollution exposures have been suggested as risk factors for childhood respiratory diseases. We investigated proximity to major roads, an indicator of air pollution exposure, and its associations with childhood recurrent wheeze and asthma. We used data from a multicenter prospective cohort study [...] Read more.
Air pollution exposures have been suggested as risk factors for childhood respiratory diseases. We investigated proximity to major roads, an indicator of air pollution exposure, and its associations with childhood recurrent wheeze and asthma. We used data from a multicenter prospective cohort study of 921 infants hospitalized for bronchiolitis and recruited from 14 U.S. states. Primary exposure was residential proximity to the nearest major road at birth through age 3 years. Residential distance from nearest major road was divided into four categories: <100, 100–200, 201–300, and >300 m. Outcomes were parent-reported recurrent wheeze by age 3 years and asthma by age 5 years. Associations between residential proximity to major roads and respiratory outcomes were investigated using multivariable Cox proportional hazards modeling and logistic regression, adjusted for confounders. Out of 920 participants with home address data, pooled estimates identified 241 (26%) participants resided within 300 m of a major road, 296 (32%) developed recurrent wheeze by age 3, and 235 out of 858 participants (27%) developed asthma by 5 years. Participants who resided close to a major road had the highest risk of recurrent wheeze (adjusted hazards ratio for <100 m, 1.59, 95%CI: 1.08–2.33) and asthma (adjusted odds ratio for 201–300 m, 1.62, 95%CI: 1.16–2.25), compared to those residing >300 m from a major road. Proximity to major roads is associated with increased risks of recurrent wheeze and asthma in young children. Full article
(This article belongs to the Special Issue Multiple Environmental and Lifestyle Determinants of Asthma and Poor Asthma Control)
►▼ Show Figures

Figure 1

13 pages, 614 KiB  
Article
Comparison of a Barcode-Based Smartphone Application to a Questionnaire to Assess the Use of Cleaning Products at Home and Their Association with Asthma Symptoms
by Pierre Lemire, Sofia Temam, Sarah Lyon-Caen, Catherine Quinot, Etienne Sévin, Sophie Remacle, Karine Supernant, Rémy Slama, Orianne Dumas, Valérie Siroux, Nicole Le Moual and the SEPAGES Study Group
Int. J. Environ. Res. Public Health 2021, 18(7), 3366; https://doi.org/10.3390/ijerph18073366 - 24 Mar 2021
Cited by 7 | Viewed by 2717
Abstract
Household disinfectant and cleaning products (HDCPs) assessment is challenging in epidemiological research. We hypothesized that a newly-developed smartphone application was more objective than questionnaires in assessing HDCPs. Therefore, we aimed to compare both methods, in terms of exposure assessments and respiratory health effects [...] Read more.
Household disinfectant and cleaning products (HDCPs) assessment is challenging in epidemiological research. We hypothesized that a newly-developed smartphone application was more objective than questionnaires in assessing HDCPs. Therefore, we aimed to compare both methods, in terms of exposure assessments and respiratory health effects estimates. The women of the SEPAGES birth cohort completed repeated validated questionnaires on HDCPs and respiratory health and used an application to report HDCPs and scan products barcodes, subsequently linked with an ingredients database. Agreements between the two methods were assessed by Kappa coefficients. Logistic regression models estimated associations of HDCP with asthma symptom score. The 101 participants (18 with asthma symptom score ≥1) scanned 617 different products (580 with available ingredients list). Slight to fair agreements for sprays, bleach and scented HDCP were observed (Kappa: 0.35, 0.25, 0.11, respectively). Strength of the associations between HDCP and asthma symptom score varied between both methods but all odds ratios (OR) were greater than one. The number of scanned products used weekly was significantly associated with the asthma symptom score (adjusted-OR [CI 95%]: 1.15 [1.00–1.32]). This study shows the importance of using novel tools in epidemiological research to objectively assess HDCP and therefore reduce exposure measurement errors. Full article
(This article belongs to the Special Issue Multiple Environmental and Lifestyle Determinants of Asthma and Poor Asthma Control)
►▼ Show Figures

Figure 1

Review

Jump to: Research

20 pages, 863 KiB  
Review
The Role of Nutritional Factors in Asthma: Challenges and Opportunities for Epidemiological Research
by Annabelle Bédard, Zhen Li, Wassila Ait-hadad, Carlos A. Camargo, Jr., Bénédicte Leynaert, Christophe Pison, Orianne Dumas and Raphaëlle Varraso
Int. J. Environ. Res. Public Health 2021, 18(6), 3013; https://doi.org/10.3390/ijerph18063013 - 15 Mar 2021
Cited by 18 | Viewed by 3722
Abstract
The prevalence of asthma has nearly doubled over the last decades. Twentieth century changes in environmental and lifestyle factors, including changes in dietary habits, physical activity and the obesity epidemic, have been suggested to play a role in the increase of asthma prevalence [...] Read more.
The prevalence of asthma has nearly doubled over the last decades. Twentieth century changes in environmental and lifestyle factors, including changes in dietary habits, physical activity and the obesity epidemic, have been suggested to play a role in the increase of asthma prevalence and uncontrolled asthma worldwide. A large body of evidence has suggested that obesity is a likely risk factor for asthma, but mechanisms are still unclear. Regarding diet and physical activity, the literature remains inconclusive. Although the investigation of nutritional factors as a whole (i.e., the “diet, physical activity and body composition” triad) is highly relevant in terms of understanding underlying mechanisms, as well as designing effective public health interventions, their combined effects across the life course has not received a lot of attention. In this review, we discuss the state of the art regarding the role of nutritional factors in asthma, for each window of exposure. We focus on the methodological and conceptual challenges encountered in the investigation of the complex time-dependent interrelations between nutritional factors and asthma and its control, and their interaction with other determinants of asthma. Lastly, we provide guidance on how to address these challenges, as well as suggestions for future research. Full article
(This article belongs to the Special Issue Multiple Environmental and Lifestyle Determinants of Asthma and Poor Asthma Control)
►▼ Show Figures

Figure 1

14 pages, 634 KiB  
Review
The Exposome Approach to Decipher the Role of Multiple Environmental and Lifestyle Determinants in Asthma
by Alicia Guillien, Solène Cadiou, Rémy Slama and Valérie Siroux
Int. J. Environ. Res. Public Health 2021, 18(3), 1138; https://doi.org/10.3390/ijerph18031138 - 28 Jan 2021
Cited by 21 | Viewed by 4727
Abstract
Asthma is a widespread respiratory disease caused by complex contribution from genetic, environmental and behavioral factors. For several decades, its sensitivity to environmental factors has been investigated in single exposure (or single family of exposures) studies, which might be a narrow approach to [...] Read more.
Asthma is a widespread respiratory disease caused by complex contribution from genetic, environmental and behavioral factors. For several decades, its sensitivity to environmental factors has been investigated in single exposure (or single family of exposures) studies, which might be a narrow approach to tackle the etiology of such a complex multifactorial disease. The emergence of the exposome concept, introduced by C. Wild (2005), offers an alternative to address exposure–health associations. After presenting an overview of the exposome concept, we discuss different statistical approaches used to study the exposome–health associations and review recent studies linking multiple families of exposures to asthma-related outcomes. The few studies published so far on the association between the exposome and asthma-related outcomes showed differences in terms of study design, population, exposome definition and statistical methods used, making their results difficult to compare. Regarding statistical methods, most studies applied successively univariate (Exposome-Wide Association Study (ExWAS)) and multivariate (adjusted for co-exposures) (e.g., Deletion–Substitution–Addition (DSA) algorithm) regression-based models. This latest approach makes it possible to assess associations between a large set of exposures and asthma outcomes. However, it cannot address complex interactions (i.e., of order ≥3) or mixture effects. Other approaches like cluster-based analyses, that lead to the identification of specific profiles of exposure at risk for the studied health-outcome, or mediation analyses, that allow the integration of information from intermediate biological layers, could offer a new avenue in the understanding of the environment–asthma association. European projects focusing on the exposome research have recently been launched and should provide new results to help fill the gap that currently exists in our understanding of the effect of environment on respiratory health. Full article
(This article belongs to the Special Issue Multiple Environmental and Lifestyle Determinants of Asthma and Poor Asthma Control)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-4
Back to TopTop