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New Challenges in Gastrointestinal Diseases
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New Challenges in Gastrointestinal Diseases

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Global Health".

Deadline for manuscript submissions: closed (27 March 2023) | Viewed by 3229

Special Issue Editor

Dr. Piotr Lewitowicz

E-Mail Website
Guest Editor
Department of Clinical and Experimental Pathology, Jan Kochanowski University in Kielce, 25-369 Kielce, Poland
Interests: GI pathology; cytology; screening; female genital tract pathology; pancreatic biopsy; liver biopsy; cellblock technics; lung cancer

Special Issue Information

Dear Colleagues,

I would like to invite you to contribute to this Special Issue of the International Journal of Environment and Public Health. The title of the upcoming issue is ‘New Challenges in Gastrointestinal Diseases’. Every day, humans ingest a vast array of chemicals that lead to the toxic injury of gastrointestinal cells, cell aging, and DNA methylation. Indeed, these chemicals can provoke gene silencing or activation, and are a direct cause of disease. However, why these chemicals lead to cancer for some people and not others is a question still under scientific investigation. In line with the aims of the International Journal of Environment and Public Health, we kindly welcome all research within this scope.

Moreover, although vast progress in medicine has provided better patient management for many, many adverse reactions and complications still require intensive investigation. This is particularly apparent in pancreato-biliary diseases. Thus, this Special Issue is dedicated to meta-analyses, reviews, and original papers that discuss and consider these issues.

Dr. Piotr Lewitowicz
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • colorectal cancer
  • methylation
  • pancreatic cancer
  • acute pancreatitis
  • methionine
  • stem cells

Published Papers (2 papers)

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Research

13 pages, 2597 KiB  
Article
The Effect of Serum Leptin Concentration and Leptin Receptor Expression on Colorectal Cancer
by Sylwia Chludzińska-Kasperuk, Jolanta Lewko, Regina Sierżantowicz, Elżbieta Krajewska-Kułak and Joanna Reszeć-Giełażyn
Int. J. Environ. Res. Public Health 2023, 20(6), 4951; https://doi.org/10.3390/ijerph20064951 - 11 Mar 2023
Cited by 1 | Viewed by 1249
Abstract
Introduction: The level of leptin in the blood shows a positive, strong correlation with the mass of adipose tissue. Being overweight and having metabolic disorders increase the risk of developing colorectal cancer. Aim of the Paper: The aim of the study was to [...] Read more.
Introduction: The level of leptin in the blood shows a positive, strong correlation with the mass of adipose tissue. Being overweight and having metabolic disorders increase the risk of developing colorectal cancer. Aim of the Paper: The aim of the study was to assess the concentration of leptin in the blood serum as well as the expression of the leptin receptor in colorectal cancer cells. In addition, the effect of serum leptin concentration and leptin receptor expression on clinical and pathological parameters such as BMI, obesity, TNM, and tumor size was assessed. Methods: The study included 61 patients diagnosed with colorectal cancer and treated with surgery. Results: Strong leptin receptor expression and the prevalence of overweight and obesity are factors influencing the occurrence of excessive leptin concentrations. Conclusion: Leptin may be involved in the development and progression of colorectal cancer. More research is needed to better elucidate the role of leptin in the development and progression of the disease. Full article
(This article belongs to the Special Issue New Challenges in Gastrointestinal Diseases)
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8 pages, 322 KiB  
Article
Iatrogenic Injury of Biliary Tree—Single-Centre Experience
by Łukasz Nawacki, Monika Kozłowska-Geller, Monika Wawszczak-Kasza, Justyna Klusek, Przemysław Znamirowski and Stanisław Głuszek
Int. J. Environ. Res. Public Health 2023, 20(1), 781; https://doi.org/10.3390/ijerph20010781 - 31 Dec 2022
Cited by 1 | Viewed by 1456
Abstract
Cholecystolithiasis is among the most prevalent gastrointestinal disorders requiring surgical intervention, and iatrogenic damage to the bile tree is a severe complication. We aimed to present the frequency of bile duct injuries and how our facility handles these complications. We retrospectively analyzed bile [...] Read more.
Cholecystolithiasis is among the most prevalent gastrointestinal disorders requiring surgical intervention, and iatrogenic damage to the bile tree is a severe complication. We aimed to present the frequency of bile duct injuries and how our facility handles these complications. We retrospectively analyzed bile duct injuries in patients undergoing surgery. We concentrated on factors such as sex, age, indications for surgery, type of surgery, primary procedure, bile tree injury, repair, and timing as well as early and late complications. There were 22 cases of bile duct injury in the studied material, primarily affecting women—15 individuals (68.2%). Eleven cases (45.7%) of acute cholecystitis were the primary reason for surgery, and an injury to the common bile duct that extended up to 2 cm from the common hepatic duct was the most common complication (European Association for Endoscopic Surgery grade 2). Roux-en-Y hepaticojejunostomy was the most common repair procedure in 14 cases (63.6%). Eleven patients (50%) experienced early complications following reconstruction surgery, whereas five patients (22.7%) experienced late complications. An annual mortality rate of 22.7% (five patients) was observed. Iatrogenic bile duct injury is a severe complication of surgical treatment for cholecystolithiasis. Reconstruction procedures are characterized by high complication rates and high mortality. Full article
(This article belongs to the Special Issue New Challenges in Gastrointestinal Diseases)
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