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Effects of Prenatal and Postnatal Exposure to Air Pollution and Diet on Lung Health in Children

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Environmental Health".

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 7334

Special Issue Editors

Department of Medicine, McMaster University, Hamilton, ON L8N 3Z5, Canada
Interests: lung growth; COPD; air pollution; occupation, cardio-respiratory diseases; biomass

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Guest Editor
1. Division of Respirology, Department of Medicine, McMaster University, Hamilton, Canada
2. St Joseph's Healthcare, Firestone Institute for Respiratory Health, Hamilton, Canada
3. Division of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester, UK
Interests: mechanisms of asthma; COPD and chronic cough; lung physiology; respiratory tract infection; clinical trials

Special Issue Information

Dear colleagues,

There has been an increase in the burden of non-communicable disease-related co-morbidities among adults, particularly in low- and middle-income countries (LMICs). Few studies, all from high income countries, have reported that adults with lower lung function during childhood have increased risk of obstructive airway disease and mortality. However, there are limited data on early life risk factors and lung health in children from LMICs. Children, particularly from LMICs, are exposed to higher concentrations of air pollution and a large proportion of them are malnourished. Children’s lungs grow until early adulthood, and as children are very active and breathe in more air while the lung is growing, they are therefore more vulnerable to air pollution.

Several studies have reported that maternal diet and exposure to air pollution affect the health of children when they are still in the womb. Continuous exposure to air pollution and poor diet are associated with poorer lung health in children with increased risk of lower respiratory infection, wheeze, and asthma. Few studies have reported that air pollution is associated with lower lung function in newborn and infants. No studies have studied the combined effect of air pollution and poor diet on lung health in children from LMICs. In LMICs, children are exposed to both household and ambient air pollution and, at the same time, many have inadequate diets. Many children from LMICs are small for their gestational age.

In this Special Issue, we invite you to share your work on the effect of prenatal or postnatal exposure to air pollution and diet on lung health in children. We would also be very interested on studies reporting on prenatal and postnatal risk factors to underweight children and see if they are at a higher risk of poor lung health. Any intervention studies on improvements regarding air pollution and better diet as well as their relationship with improvements in lung health are of particular interest.

Dr. Om Kurmi
Dr. Imran Satia
Guest Editors

Manuscript Submission Information

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Keywords

  • Air pollution
  • Household
  • Ambient air pollution
  • Lung growth
  • Lung function
  • Asthma
  • Wheeze
  • Lower respiratory tract infection
  • Intervention
  • Dietary patterns
  • Protein
  • Fruit and vegetables
  • Small for gestational age

Published Papers (2 papers)

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15 pages, 3027 KiB  
Article
Diesel Particulate Matter 2.5 Induces Epithelial-to-Mesenchymal Transition and Upregulation of SARS-CoV-2 Receptor during Human Pluripotent Stem Cell-Derived Alveolar Organoid Development
by Jung-Hyun Kim, Jeeyoung Kim, Woo Jin Kim, Yung Hyun Choi, Se-Ran Yang and Seok-Ho Hong
Int. J. Environ. Res. Public Health 2020, 17(22), 8410; https://doi.org/10.3390/ijerph17228410 - 13 Nov 2020
Cited by 33 | Viewed by 3910
Abstract
Growing evidence links prenatal exposure to particulate matter (PM2.5) with reduced lung function and incidence of pulmonary diseases in infancy and childhood. However, the underlying biological mechanisms of how prenatal PM2.5 exposure affects the lungs are incompletely understood, which explains the lack of [...] Read more.
Growing evidence links prenatal exposure to particulate matter (PM2.5) with reduced lung function and incidence of pulmonary diseases in infancy and childhood. However, the underlying biological mechanisms of how prenatal PM2.5 exposure affects the lungs are incompletely understood, which explains the lack of an ideal in vitro lung development model. Human pluripotent stem cells (hPSCs) have been successfully employed for in vitro developmental toxicity evaluations due to their unique ability to differentiate into any type of cell in the body. In this study, we investigated the developmental toxicity of diesel fine PM (dPM2.5) exposure during hPSC-derived alveolar epithelial cell (AEC) differentiation and three-dimensional (3D) multicellular alveolar organoid (AO) development. We found that dPM2.5 (50 and 100 μg/mL) treatment disturbed the AEC differentiation, accompanied by upregulation of nicotinamide adenine dinucleotide phosphate oxidases and inflammation. Exposure to dPM2.5 also promoted epithelial-to-mesenchymal transition during AEC and AO development via activation of extracellular signal-regulated kinase signaling, while dPM2.5 had no effect on surfactant protein C expression in hPSC-derived AECs. Notably, we provided evidence, for the first time, that angiotensin-converting enzyme 2, a receptor to mediate the severe acute respiratory syndrome coronavirus clade 2 (SARS-CoV-2) entry into target cells, and the cofactor transmembrane protease serine 2 were significantly upregulated in both hPSC-AECs and AOs treated with dPM2.5. In conclusion, we demonstrated the potential alveolar development toxicity and the increase of SARS-Cov-2 susceptibility of PM2.5. Our findings suggest that an hPSC-based 2D and 3D alveolar induction system could be a useful in vitro platform for evaluating the adverse effects of environmental toxins and for virus research. Full article
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7 pages, 565 KiB  
Systematic Review
The Effects of Household Air Pollution (HAP) on Lung Function in Children: A Systematic Review
by Sathya Swarup Aithal, Shireen Gill, Imran Satia, Sudhir Kumar Tyagi, Charlotte E. Bolton and Om P. Kurmi
Int. J. Environ. Res. Public Health 2021, 18(22), 11973; https://doi.org/10.3390/ijerph182211973 - 15 Nov 2021
Cited by 8 | Viewed by 2732
Abstract
The World Health Organization (WHO) estimates that around 3 billion people today are exposed to smoke from the household combustion of solid fuels. While the household use of solid fuels has decreased over the last few decades, it remains a leading modifiable risk [...] Read more.
The World Health Organization (WHO) estimates that around 3 billion people today are exposed to smoke from the household combustion of solid fuels. While the household use of solid fuels has decreased over the last few decades, it remains a leading modifiable risk factor for the global burden of disease. This systematic review analyzed the impact of Household Air Pollution (HAP) on lung function in children (under 18 years of age), as this is the time period of accelerated growth rate until full skeletal maturity. Data from 11 published studies demonstrated that exposure to smoke from solid fuel was associated with a lower growth rate of several lung function indices (FVC, FEV1, FEF25–75) in children. However, there was no observed association between HAP and the FEV1/FVC ratio over time. Although the evidence suggests an inverse association between high exposure to HAP and lung function indices, there is a lack of longitudinal data describing this association. Therefore, precaution is needed to reduce the smoke exposure from solid fuel burning. Full article
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