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Hair Disorders

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601).

Deadline for manuscript submissions: closed (4 March 2019) | Viewed by 5275

Special Issue Editor


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Guest Editor
Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield, Medical School, Beech Hill Road, Sheffield S10 2RX, UK
Interests: determination of the function of the autoimmune regulator (AIRE) gene and its role in the pathogenesis of autoimmune diseases such as alopecia areata, vitiligo and thyroid diseases

Special Issue Information

The hair follicle (HF) has a range of biological functions including thermoregulation, wound healing, and sensory function, as well as a social function in which hair is an important part of an individual’s self-image. Hair disorder can cause the alteration of one of more of these functions. Development of molecular biology techniques, as well as methods of high-throughput screening, has made it possible to identify genes involved in the pathogenesis of a range of human diseases, as well as to identify molecules involved in the control of gene expression. This Special Issue will focus on hair disorders research in basic science, through animal testing of potentially therapeutic molecules, to clinical trials. For instance, decades of basic research on alopecia areata, an autoimmune disease of HF, has led to the identification of an important JAK-STAT pathway in the pathology of the disease, and the testing of JAK inhibitors molecules such as ruxolitinib, tofacitinib, and baricitinib on animal models has shown successful results in alopecia areata patients. In this issue, we would like to invite you to share with us your latest discoveries and developments regarding hair disorders.

Dear Colleagues,

IJERPH is organising a focus theme issue “Hair Disorders”. We would greatly appreciate it if you could contribute and write a review article, original article, or brief communication for this themed issue.

We invite you to address one of the important aspects of hair biology and hair disorders. As an eminent researcher in the field of hair molecular biology, we were hoping you could provide your view and an update on the recent development in this field of research.

Original article: a maximum of 3000 words, including an abstract of 250 words.

Communication: a speculative, thought-provoking essay, with a maximum of 2000 words and 9 references.

A standard review article: a maximum of 4000 words.

Our deadline for the submission of your article for this issue will be 4 March 2019.

We hope you kindly agree to help with this project.

With warmest wishes,

Dr. Rachid Tazi-Ahnini
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hair disorders
  • hair follicle
  • genetics of hair disorders
  • autoimmunity in hair disorders
  • treatment of hair disorders

Published Papers (1 paper)

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Research

19 pages, 3085 KiB  
Article
Epigallocatechin-3 Gallate Inhibits STAT-1/JAK2/IRF-1/HLA-DR/HLA-B and Reduces CD8 MKG2D Lymphocytes of Alopecia Areata Patients
by Fatma N. Hamed, Andrew J. G. McDonagh, Sarah Almaghrabi, Youssef Bakri, Andrew G. Messenger and Rachid Tazi-Ahnini
Int. J. Environ. Res. Public Health 2018, 15(12), 2882; https://doi.org/10.3390/ijerph15122882 - 15 Dec 2018
Cited by 13 | Viewed by 4718
Abstract
Background: Alopecia areata (AA) is associated with Interferon- γ (IFN-γ) mediated T-lymphocyte dysfunction and increased circulating Interleukine-17 (IL-17) levels. Epigallocatechin-3-gallate (EGCG) specifically inhibits IFN-γ pathways and unlike Janus Kinase 1 and 2 (JAK1/JAK2) inhibitors (tofacitinib, ruxolitinib), EGCG is safer, more cost-effective, and is [...] Read more.
Background: Alopecia areata (AA) is associated with Interferon- γ (IFN-γ) mediated T-lymphocyte dysfunction and increased circulating Interleukine-17 (IL-17) levels. Epigallocatechin-3-gallate (EGCG) specifically inhibits IFN-γ pathways and unlike Janus Kinase 1 and 2 (JAK1/JAK2) inhibitors (tofacitinib, ruxolitinib), EGCG is safer, more cost-effective, and is a topically active agent. Our objective is to test the mode of action of EGCG in vitro and ex vivo using HaCat, Jurkat cell lines, and peripheral blood mononuclear cells (PBMCs) of AA patients and healthy controls (HCs), respectively. Methods: distribution of T helper cells (Th1, Th17), and cytotoxic cells (CD8) in PBMCs isolated from 30 AA patients and 30 HCs was investigated by flowcytomterty. In vitro treatment of HaCat and Jurkat cells with 40 μm EGCG for 48 h was performed to measure the level of phosphorylation of signal transducer and activator of transcription protein STAT1, and replicated in ex vivo model using PBMCs of AA patients. Results: Interestingly, 40 μm EGCG is capable of completely inhibiting phosphorylation of STAT1 after 48 h in HaCat and Jurkat cells and ex vivo in PBMCs of AA patients. Based on QPCR data, the action of EGCG on p-STAT1 seems to be mediated via downregulation of the expression of JAK2 but not JAK1 leading to the inhibition of human leukocyte antigens (HLA-DR and HLA-B) expression probably via IRF-1. On the other hand, AA patients have significantly increased levels of Th1, Th17, and CD8 cells and the production of IFN-γ and IL-17 by PBMCs in AA patients was significantly higher compared to HC; p = 0.008 and p = 0.006, respectively. Total numbers of CD8+ cells were not significantly different between treated and untreated samples. However, CD8+ cells with positive Natural killer group 2 member D (NKG2D) transmembrane receptor (CD8+ NKG2D+ subset) was significantly reduced when PBMCs were treated with 20 μm EGCG for 48 h. Conclusion: These results suggest that EGCG has a synergistic action that inhibits expression of HLA-DR and HLA-B molecules via the IFN-γ pathway to maintain immune privilege in HF; also it reduces CD8+ NKG2D+ subset. Full article
(This article belongs to the Special Issue Hair Disorders)
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