Current Therapeutic Trends and Challenges in the Management of Patients with Type 2 Diabetes Mellitus
A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601).
Deadline for manuscript submissions: closed (30 September 2019) | Viewed by 52733
Special Issue Editors
2. Research Laboratory Christeas Hall, Medical School, National Kapodistrian University of Athens, 11527 Athens, Greece
Interests: appetite-related hormones; diabetes mellitus; nutrition and atherosclerosis; obesity; postprandial metabolism
Special Issues, Collections and Topics in MDPI journals
Interests: diabetes mellitus; obesity; metabolic dysfunction-associated steatotic liver disease (MASLD); metabolic surgery; body composition; cardiovascular disease; insulin resistance; mitochondrial function
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The optimal management of patients with type 2 diabetes mellitus (T2DM) is multifactorial. The major goals of treatment are the prevention or delay of complications and the maintenance of quality of life in a relatively cost-effective manner. This requires an efficient control of hyperglycemia to reduce glucotoxicity, an improvement of coexistent cardiovascular risk factors to optimise cardiovascular outcomes, regular monitoring and re-assessment of treatment goals to ensure patients’ adherence to therapy, and importantly, a patient-focused approach to enhance patient engagement in self-care activities. Individual patient factors and preferences should be carefully considered in order to inform the process of therapeutic decision-making. In this context, the updated position statements of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) place particular emphasis on individualizing glycemic control targets based upon patient preferences, risk of treatment-related adverse effects (especially hypoglycemia and weight gain), and clinical characteristics such as age, frailty and comorbid conditions. Those comorbidities which are particularly relevant for individualizing T2DM treatment are atherosclerotic cardiovascular disease, heart failure and chronic kidney disease. The key factors to guide the selection of appropriate glucose-lowering medication after lifestyle modification and metformin, which are considered as first-line treatment in all patients, are efficacy, safety, tolerability, individual patient preferences and comorbidities, side effects and costs.
The present Special Issue aims to cover a broad range of pharmacological and non-pharmacological therapeutic options for T2DM with proven efficacy to reduce complications and optimise quality of life. Both conventional treatment modalities, as recommended in consensus reports and evidence-based treatment algorithms of international scientific societies, and novel experimental therapies based on solid underlying pathophysiological concepts, can be presented. In this Special Issue, we invite the submission of manuscripts (original research or review articles) addressing fundamental aspects of T2DM management including, but not limited to, medical nutrition therapy, physical activity, bariatric (metabolic) surgery, stress management techniques, oral and injectable formulations, diabetes self-management, education and support, and the integration of evolving technologies such as continuous glucose monitoring. Papers addressing T2DM management in specific patient subgroups such as older patients, pregnant women, adolescents and patients with specific comorbidities such as obesity, non-alcoholic fatty liver disease, established cardiovascular disease and chronic kidney disease, are particularly welcome. We encourage authors to focus on recent therapeutic advances in the field of T2DM management, present novel data and emerging therapeutic concepts, and discuss with a critical perspective both advantages and possible caveats or limitations of specific treatment strategies. All therapeutic approaches discussed should be targeted at reducing complications and optimising health outcomes in patients with T2DM, in the context of comprehensive cardiovascular risk management and individualized (patient-centered) care.
Prof. Dr. Nicholas Katsilambros
Dr. Chrysi Koliaki
Guest Editors
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Keywords
- Bariatric surgery
- Cardiovascular disease
- Comorbidities
- Hyperglycemia
- Individualized treatment
- Lifestyle modification
- Medical nutrition
- Obesity
- Type 2 diabetes mellitus
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