Novel Aspects in the Pathophysiology and Treatment of Diabetes Mellitus
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Endocrinology and Metabolism Research".
Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 20988
Special Issue Editors
Interests: diabetes mellitus; obesity; non-alcoholic fatty liver disease (NAFLD); bariatric surgery; body composition; cardiovascular disease; insulin resistance; metabolically healthy obese; mitochondrial function
Special Issues, Collections and Topics in MDPI journals
2. Research Laboratory Christeas Hall, Medical School, National Kapodistrian University of Athens, 11527 Athens, Greece
Interests: appetite-related hormones; diabetes mellitus; nutrition and atherosclerosis; obesity; postprandial metabolism
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Diabetes mellitus, the contemporary metabolic pandemic, represents a complex multifactorial syndrome characterized by abnormalities in every single aspect of cellular energy metabolism. Type 1 diabetes mellitus (T1DM) is associated with reduced endogenous insulin secretion due to progressive autoimmune destruction of insulin-producing pancreatic β-cells. Type 2 diabetes mellitus (T2DM) is associated with both insulin resistance and defective insulin secretion. Beyond T1DM and T2DM, distinct phenotypes of diabetes with varying degrees of insulin resistance and pancreatic β-cell defects have been characterized in the literature. The major pathophysiological mechanisms underlying the pathogenesis of diabetes and its related complications involve insulin resistance; immunological defects; an impaired incretin effect; gluco- and lipotoxicity; inflammation; oxidative stress; endoplasmic reticulum stress; defective autophagy mechanisms; proapoptotic pathways; alterations in the gut microbiome; and abnormal mitochondrial function in insulin-responsive tissues such as liver, skeletal muscle, adipose tissue, vessels, nervous system and myocardium. In recent years, evidence-based treatment algorithms for diabetic patients, focusing on patients’ comorbidities as a critical determinant of the selection of the most appropriate glucose-lowering treatment, have been proposed. The most relevant comorbidities are atherosclerotic cardiovascular disease, heart failure, chronic kidney disease and obesity. Sodium-glucose co-transporter 2 inhibitors (SGLT2) and glucagon-like peptide 1 (GLP-1) receptor agonists are prominent in current therapeutic practice due to their pleiotropic, mainly cardio- and renoprotective, effects.
The aim of this Special Issue is to provide a platform for sharing all the novel insights into the pathophysiology and treatment of diabetes mellitus. Both original research and comprehensive review articles on this topic are invited for submission. Papers on potential novel biomarkers for the prediction of diabetes and its complications (including the omics technology); pathophysiological concepts related to the mechanisms described above; and treatment strategies (medical nutrition, metabolic surgery, drugs, innovative approaches based on nanotechnology or artificial intelligence) in the context of precision diabetology are particularly welcome.
Dr. Chrysi Koliaki
Prof. Dr. Nicholas Katsilambros
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- type 1 diabetes mellitus
- type 2 diabetes mellitus
- insulin resistance
- pathophysiology
- treatment
- precision medicine
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.