The Role of Natural Products in Skin Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".
Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 17466
Special Issue Editor
Interests: skin pharmacology; ocular pharmacology; cardiovascular pharmacology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The major function of the skin is as a barrier against the external environment, which plays a particularly important role in maintaining the health of the body. Conditions of the human integumentary system constitute a broad spectrum of diseases, such as atopic dermatitis (AD), psoriasis and cutaneous lupus erythematosus.
Among them, atopic dermatitis (AD) is induced by two hypothetical causes: from the inside out, or from the outside in. Allergy triggers lead to a weakened skin barrier, which facilitates the introduction and presentation of allergens. This suggests that inflammation is the culprit for an impaired skin barrier, leading to increased penetration of allergens and response-causing microorganisms, i.e., the inside-out hypothesis. In the other hypothesis, it is the skin barrier that is damaged prior to AD, and this is required for the development of immune dysregulation. For example, the downregulation of filaggrin, which is required for the skin barrier function, may make the skin more susceptible to immune dysregulation and lead to AD. This is the outside-in hypothesis. Many skin diseases, including atopic dermatitis and psoriasis, do not yet have an effective, economical treatment with few side effects.
Natural products are those chemical substances produced by living organisms in nature that usually have pharmacological or biological activity. Natural products have been found in the past to regulate allergy and anti-inflammatory effects. It is believed that many ingredients have the ability to modulate the intrinsic and extrinsic factors that cause skin disease. Through this Special Issue, more potential natural candidate ingredients may be discovered and published.
Prof. Dr. Chi-Feng Hung
Guest Editor
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Keywords
- skin disease
- atopic dermatitis
- skin barrier
- allergy
- inflammation
- cytokine
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