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Advanced Research of Metallic Nanoparticles

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".

Deadline for manuscript submissions: 29 August 2024 | Viewed by 824

Special Issue Editor


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Guest Editor
AGH University of Krakow, Faculty of Foundry Engineering, 23 Reymonta Str., 30-059 Krakow, Poland
Interests: material characterization; nanomaterials; physical chemistry; biochemistry; molecular spectroscopy; surface analysis; adsorption
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Special Issue Information

Dear Colleagues,

Metallic nanoparticles (MNPs) have been known about since ancient times, when they were used for decoration. To date, the fascination with them has not diminished, and there is a growing interest in their application for the creation and design of extremely sensitive and specific biochemical nanosensors (e.g., glucose, phenol, H2O2, cholesterol, urea, lactic acid, DNA, proteins, breast cancer markers, etc.), additives for bone scaffolds, protective coatings for implants (laryngology, cardiology, orthopedics, or stomatology), drug and gene carriers, nano-adjuvants, biomedical imaging, and some chemical/physical properties (e.g., pH). MNPs also find various applications in catalysis, optics, electronics, food processing, cosmetics, high-density information storage, energy conversion, and construction (e.g., roofs, ceilings), among others. This wide application is due to the properties of MNPs, including their large surface area and versatile surface chemistry, controlled toxicity, good biocompatibility and biodegradability, chemical resistance, thermal stability, and ease of application.

By suitably selecting the nanostructure and composition of MNPs, it is possible to obtain not only biocompatible nanoparticles, but also nanoparticles that exhibit selective biological/chemical activities with respect to the selected compounds that interact (via adsorption and desorption processes) with a surface of interest (reaction at the solid–liquid(gas) interface). The interactions among biological, organic, and inorganic molecules and a metal surface are a central topic in biotechnology and biochemistry. Since biotechnological research relates to processes at the molecular and cellular level, the structure and properties of the interface must be designed and controlled at this level. Therefore, the metal interface is often used in the form of metallic nanoparticles obtained under controlled conditions in an aqueous medium via chemical, electrochemical, and laser ablation methods, as well as by the sol–gel method, the hydrothermal method, co-precipitation, microwave-assisted synthesis, or the “green chemistry” method using prokaryotic bacteria or eukaryotic fungi and plants.

The nanoscale properties of the interface between the biological and physical systems are a common theme in many different devices. Therefore, there has been a constant search for MNPs with improved properties, constant research on the development of their ecological, low-cost and efficient synthesis methods, and numerous studies on novel application areas or attempts to understand the relationship between their structure and properties. The aim of this Special Issue is to provide insights into recent advances in the above research areas, focusing on the advantages, limitations, and future directions of the application of metallic nanoparticles in molecular biology and molecular medicine. Researchers are invited to share their ideas and findings on these exciting topics. Original research papers and review articles are welcome.

Prof. Dr. Edyta Proniewicz
Guest Editor

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Keywords

  • metallic nanoparticles (MNPs)
  • biosensors
  • synthesis methods
  • molecular spectroscopy characteristic
  • molecular medicine
  • molecular biology

Published Papers (1 paper)

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Research

19 pages, 4067 KiB  
Article
Gold and Silver Nanoparticles as Biosensors: Characterization of Surface and Changes in the Adsorption of Leucine Dipeptide under the Influence of Substituent Changes
by Edyta Proniewicz
Int. J. Mol. Sci. 2024, 25(7), 3720; https://doi.org/10.3390/ijms25073720 - 27 Mar 2024
Viewed by 556
Abstract
Early detection of diseases can increase the chances of successful treatment and survival. Therefore, it is necessary to develop a method for detecting or sensing biomolecules that cause trouble in living organisms. Disease sensors should possess specific properties, such as selectivity, reproducibility, stability, [...] Read more.
Early detection of diseases can increase the chances of successful treatment and survival. Therefore, it is necessary to develop a method for detecting or sensing biomolecules that cause trouble in living organisms. Disease sensors should possess specific properties, such as selectivity, reproducibility, stability, sensitivity, and morphology, for their routine application in medical diagnosis and treatment. This work focuses on biosensors in the form of surface-functionalized gold (AuNPs) and silver nanoparticles (AgNPs) prepared using a less-time-consuming, inexpensive, and efficient synthesis route. This allows for the production of highly pure and stable (non-aggregating without stabilizers) nanoparticles with a well-defined spherical shape, a desired diameter, and a monodisperse distribution in an aqueous environment, as confirmed by transmission electron microscopy with energy-dispersive X-ray spectroscopy (TEM-EDS), X-ray diffraction (XRD), photoelectron spectroscopy (XPS), ultraviolet-visible (UV-VIS) spectroscopy, and dynamic light scattering (DLS). Thus, these nanoparticles can be used routinely as biomarker sensors and drug-delivery platforms for precision medicine treatment. The NPs’ surface was coated with phosphonate dipeptides of L-leucine (Leu; l-Leu–C(R1)(R2)PO3H2), and their adsorption was monitored using SERS. Reproducible spectra were analyzed to determine the orientation of the dipeptides (coating layers) on the nanoparticles’ surface. The appropriate R2 side chain of the dipeptide can be selected to control the arrangement of these dipeptides. This allows for the proper formation of a layer covering the nanoparticles while also simultaneously interacting with the surrounding biological environment, such as cells, tissues, and biological fluids. Full article
(This article belongs to the Special Issue Advanced Research of Metallic Nanoparticles)
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