MicroRNAs in the Pathophysiology of Chronic Diseases: 2nd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 61
Special Issue Editors
Interests: stem cell; bioactive molecules; pulmonary disease; aging related disease; senescence; miRNA
Special Issues, Collections and Topics in MDPI journals
Interests: stem cells; mesenchymal stromal/stem cells; neural stem cells; clinical trials with stem cells; senescence; apoptosis; authophagy; cell cycle; differentiation; DNA repair; proteasome activity; cancer cells; neurodegenerative disorders
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue is the second volume of our Special Issue series, “MicroRNAs in the Pathophysiology of Chronic Diseases”. MicroRNAs (miRNAs) are a class of small non-coding RNA molecules. MiRNAs block translation and/or promote mRNA degradation by binding to the 3′-untranslated regions of messenger RNAs. A consistent body of literature has acknowledged the key role of miRNAs in a wide range of physiological processes (e.g., cell proliferation, differentiation, and survival) and pathophysiological processes, including cancer, cardiovascular diseases, metabolic disorders, and neurodegenerative diseases.
MiRNAs target multiple mRNAs that could be altered in disease conditions. This makes these molecules interesting candidates for use as therapeutics or as targets for therapeutics. Advances in RNA chemistry and delivery technologies, including nanoparticle systems, have now enabled the first miRNA-based agents to be used in the clinic. MiRNAs can also be useful tools for dissecting the molecular pathways involved in disease progression. Substantial evidence has shown that natural products such as paclitaxel, curcumin, resveratrol, genistein, and epigallocatechin-3-gallate exert their anti-proliferative and/or pro-apoptotic effects by regulating one or more miRNAs.
Moreover, the presence of circulating miRNAs in serum, plasma, and other bodily fluids implies the possibility of exploring their potential usefulness as biomarkers for different diseases. As most studies have focused on the association between the changes in miRNAs and a clearly defined stage in a disease, it is intriguing to investigate both the physiological and miRNA changes in patients suffering from many chronic diseases.
This Special Issue welcomes original research and critical reviews on the role of miRNAs (long non-coding RNAs, but circular-RNAs are also accepted) in physiological and pathological processes. Potential topics for inclusion in this Special Issue include, but are not limited to, the following: i. the molecular mechanisms and regulatory pathways influenced by non-coding RNAs; ii. the prognostic and therapeutic relevance of these molecules, and iii. their role in chronic diseases (such as cancer, cardiovascular disease, neurological diseases, immune-related diseases, and metabolic disorders) and in response to unhealthy habits and environmental stressors.
Dr. Mauro Finicelli
Dr. Tiziana Squillaro
Guest Editors
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Keywords
- miRNA
- lncRNA
- circRNA
- circulating miRNAs
- cancer
- cardiovascular disease
- neurological diseases
- metabolic diseases
- immunological diseases
- nutraceutical
- nanodelivery systems
- environmental stressors
- unhealthy habits
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